Browsing Department of Clinical Medicine by Title
Now showing items 1627-1646 of 2066
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Priorities for research in trauma care: creating a bucket list
(Journal article; Peer reviewed, 2020) -
Probiotics in irritable bowel syndrome: An up-to-date systematic review
(Peer reviewed; Journal article, 2019-09-02)Irritable bowel syndrome (IBS) is a frequent functional gastrointestinal disorder, and alterations in the gut microbiota composition contributes to symptom generation. The exact mechanisms of probiotics in the human body ... -
Profiling and functional analysis of microRNA deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microRNA-204 via regulation of their motility
(Journal article; Peer reviewed, 2021-11-04)Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous ... -
Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study
(Peer reviewed; Journal article, 2018-05-31)Background. The value of a histologic classification scheme to classify patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into focal, mixed, crescentic, and sclerotic types for ... -
Prognostic and predictive impact of stroma cells defned by PDGFRb expression in early breast cancer: results from the randomized SweBCG91RT trial
(Journal article; Peer reviewed, 2021)Purpose Predictive biomarkers are needed to aid the individualization of radiotherapy (RT) in breast cancer. Cancer-associated fibroblasts have been implicated in tumor radioresistance and can be identified by platelet-derived ... -
Prognostic factors in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with severe glomerular sclerosis: a national registry-based cohort study
(Peer reviewed; Journal article, 2018-06-03)Background. Classification of patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into histological classes is useful for predicting a patient’s risk of progression to end-stage renal ... -
Prognostic factors in renal cell carcinoma. A retrospective population based study focusing on the clear cell type
(Doctoral thesis, 2010-09-24) -
Prognostic models for the early care of trauma patients: a systematic review
(Peer reviewed; Journal article, 2011-03-20)Background: Early identification of major trauma may contribute to timely emergency care and rapid transport to an appropriate health-care facility. Several prognostic trauma models have been developed to improve early ... -
Prognostic performance of preoperative cardiac troponin and perioperative changes in cardiac troponin for the prediction of major adverse cardiac events and mortality in noncardiac surgery: A systematic review and meta-analysis
(Peer reviewed; Journal article, 2019-04-22)Background Increased postoperative cardiac troponin (cTn) independently predicts short-term mortality. Previous studies suggest that preoperative cTn also predicts major adverse cardiovascular events (MACE) and mortality ... -
Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients
(Peer reviewed; Journal article, 2017-09-05)Background: Patients with early colorectal cancer (stages I–II) generally have a good prognosis, but a subgroup of 15–20% experiences relapse and eventually die of disease. Occult metastases have been suggested as a marker ... -
The prognostic relevance of interactions between venous invasion, lymph node involvement and distant metastases in renal cell carcinoma after radical nephrectomy
(Peer reviewed; Journal article, 2008-12-19)Background: To investigate a possible prognostic significance of interactions between lymph node invasion (LNI), synchronous distant metastases (SDM), and venous invasion (VI) adjusted for mode of detection, Eastern ... -
Prognostic value of bone marrow involvement by clonal immunoglobulin gene rearrangements in follicular lymphoma
(Peer reviewed; Journal article, 2014-09-18)Aims: We aimed to evaluate the prognostic value of routine use of PCR amplification of immunoglobulin gene rearrangements in bone marrow (BM) staging in patients with follicular lymphoma (FL). Methods: Clonal rearrangements ... -
Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma
(Peer reviewed; Journal article, 2019-01-14)Angiogenesis is important for the progression of cutaneous melanoma. Here, we analyzed the prognostic impact of the angiogenic factor urokinase plasminogen activator resecptor (uPAR), vascular proliferation index (VPI) and ... -
Prognostication after out-of-hospital cardiac arrest, a clinical survey
(Peer reviewed; Journal article, 2008-09-15)Background: Numerous parameters and tests have been proposed for outcome prediction in comatose out-of-hospital cardiac arrest survivors. We conducted a survey of clinical practice of prognostication after therapeutic ... -
Progressive striatal necrosis associated with anti-NMDA receptor antibodies
(Peer reviewed; Journal article, 2013-05-31)Background: We report a case of childhood onset, generalized dystonia due to slowly progressive bilateral striatal necrosis associated with anti-N-methyl-D-aspartate receptor (NMDAR) antibodies. This clinical phenotype has ... -
Proliferation in operable breast cancer : Aspects of prognostication and relevance of carbohydrate metabolism
(Doctoral thesis, 2020-03-06)Breast cancer is the most common malignant disease among women in the Western world. In Norway and the Netherlands, the incidence has more than doubled in the last 50 years, likely due to increased estrogen exposure, higher ... -
Proliferation, lymph vessel invasion and histologic type as prognostic factors in lymph node negative breast cancer
(Doctoral thesis, 2011-12-14)Breast cancer is a leading cause of cancer mortality among women in the western world, second only to lung cancer. Since the mammography screening program in Norway started in 1995, 70% and more of all new breast cancers ... -
Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation
(Peer reviewed; Journal article, 2017)Introduction: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C ... -
A proper lookout. Studies of contrast sensitivity
(Doctoral thesis, 2018-09-14)Naval navigation and watch keeping in littoral waters is highly dependent on visual function, and all navigators are required to have normal visual acuity (VA) measured by Snellen’s table or equivalent. Although visual ... -
Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative
(Peer reviewed; Journal article, 2019-09-25)Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains ...