Blar i Department of Clinical Medicine på tittel
Viser treff 1374-1393 av 2101
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The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease
(Journal article; Peer reviewed, 2024)Alpers' syndrome is an early-onset neurodegenerative disorder usually caused by biallelic pathogenic variants in the gene encoding the catalytic subunit of polymerase-gamma (POLG), which is essential for mitochondrial DNA ... -
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease
(Journal article; Peer reviewed, 2022)We conducted a double-blinded phase I clinical trial to establish whether nicotinamide adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside (NR), is safe, augments cerebral NAD levels, ... -
Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models
(Peer reviewed; Journal article, 2016)BACKGROUND: Oral cavity is a doorway for a variety of products containing titanium dioxide (TiO2) nanoparticles (NPs) (nano-TiO2) such as food additives, oral healthcare products and dental materials. Their potential to ... -
Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes
(Peer reviewed; Journal article, 2016-07)This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance ... -
National Norwegian Practice Patterns for Surgical Treatment of Kidney Cancer Tumors ≤7 cm: Adherence to Changes in Guidelines May Improve Overall Survival
(Peer reviewed; Journal article, 2018-08)Background: Guidelines on surgical treatment for kidney cancer (KC) have changed over the last 10 yr. We present population-based data for patients with KC tumors ≤7 cm from 2008 to 2013 to investigate whether surgical ... -
A nationwide study of the incidence, prevalence and mortality of Parkinson’s disease in the Norwegian population
(Journal article; Peer reviewed, 2022)Epidemiological studies of Parkinson’s disease (PD) show variable and partially conflicting findings with regard to incidence, prevalence, and mortality. These differences are commonly attributed to technical and methodological ... -
Natural Variation of Vitamin D and Neurofilament Light Chain in Relapsing-Remitting Multiple Sclerosis
(Journal article; Peer reviewed, 2020-04-30)Background: High serum levels of 25-hydroxyvitamin D (25(OH)D) have been found among patients with a favorable disease course in relapsing-remitting MS (RRMS), indicating that this may limit clinical deterioration. Clinical ... -
A Naturalistic Study of the Effect of Acupuncture on Heart-Rate Variability
(Peer reviewed; Journal article, 2012-02)Objectives: To study the effect of acupuncture on heart rate variability (HRV) by using linear and non-linear methods of analysis. Methods: 40 patients were recruited consecutively, including patients with insomnia, ... -
Navigated retrograde endoscopic myotomy (REM) for the treatment of therapy-resistant achalasia
(Peer reviewed; Journal article, 2018-04)Background In achalasia, muscle spasm may involve the proximal esophagus. When the muscle spasm is located in the proximal esophagus, conventional per oral endoscopic myotomy (POEM) may not be sufficient to relieve symptoms. ... -
Neck pain associated with clinical symptoms in dizzy patients- A cross-sectional study
(Peer reviewed; Journal article, 2020)Objective: Many patients suffer from concurrent neck pain and dizziness. The aim of this study was to describe the clinical symptoms and physical findings in patients with concurrent neck pain and dizziness and to examine ... -
Negotiating the boundaries of psychosis: A qualitative studyof the service provider perspective on treatment delay incommunity mental health
(Peer reviewed; Journal article, 2017)Aim: Evidence shows that many patients are detected and treated late in their course of illness, and that substantial delay occurs even after entry to mental health services. Although several studies have examined the ... -
Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial
(Peer reviewed; Journal article, 2017-08-25)Background: Pancreatic cancer is the fourth leading cause of cancer-related death. While surgical resection remains the foundation for potentially curative treatment, survival benefit is achieved with adjuvant oncological ... -
Neoadjuvant immunotherapy in primary and metastatic colorectal cancer
(Journal article; Peer reviewed, 2021)Background Colorectal cancer (CRC) is the second most common solid organ cancer. Traditional treatment is with surgery and chemotherapy. Immunotherapy has recently emerged as a neoadjuvant therapy that could change treatment ... -
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of infammation measured three months after ischemic stroke
(Journal article; Peer reviewed, 2021)Background Chronic low-grade inflammation is associated with both ischemic stroke and sedentary behaviour. The aim of this study was to investigate the predictive abilities of biomarkers of inflammation and immune modulation ... -
Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target
(Journal article; Peer reviewed, 2023)Background: Minimal change disease (MCD), a major cause of nephrotic syndrome, is usually treated by corticosteroid administration. MCD unresponsiveness to therapy and recurrences are nonetheless frequently observed, ... -
Neural tube defect among children in Addis Ababa Ethiopia: Epidemiological pattern and treatment outcome
(Doctoral thesis, 2024-08-23)Bakgrunn: Ni av ti barn med alvorlige medfødte misdannelser blir født i lav- og mellominntektsland (LMIC). Nevrale rørbrokk (NTD) er en av de vanligste misdannelsene. Målet med denne studien er å estimere forekomst, ... -
Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation
(Journal article; Peer reviewed, 2023)Background: Noninvasive neurostimulation treatments are increasingly being used to treat major depression, which is a common cause of disability worldwide. While electroconvulsive therapy (ECT) and transcranial magnetic ... -
Neuroborreliosis in children: Epidemiological and clinical aspects
(Doctoral thesis, 2012-06-08)Background: Lyme borreliosis (LB) caused by the bacteria Borrelia burgdorferi sensu lato (Bbsl) is the most common tick transmitted infection in Europe. LB is a multi systemic infection that develops when the bacteria ... -
Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression
(Peer reviewed; Journal article, 2013-04-04)Background: The literature on the neuropsychological profiles in Bipolar disorder (BD) depression is sparse. The aims of the study were to assess the neurocognitive profiles in treatment-resistant, acutely admitted BD ... -
Neurofeedback for the treatment of children and adolescents with ADHD: a randomized and controlled clinical trial using parental reports
(Peer reviewed; Journal article, 2012-08-10)Background: A randomized and controlled clinical study was performed to evaluate the use of neurofeedback (NF) to treat attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. Methods: The ADHD population ...