Blar i Department of Clinical Medicine på tittel
Viser treff 1665-1684 av 2095
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Progressive striatal necrosis associated with anti-NMDA receptor antibodies
(Peer reviewed; Journal article, 2013-05-31)Background: We report a case of childhood onset, generalized dystonia due to slowly progressive bilateral striatal necrosis associated with anti-N-methyl-D-aspartate receptor (NMDAR) antibodies. This clinical phenotype has ... -
Proliferation in operable breast cancer : Aspects of prognostication and relevance of carbohydrate metabolism
(Doctoral thesis, 2020-03-06)Breast cancer is the most common malignant disease among women in the Western world. In Norway and the Netherlands, the incidence has more than doubled in the last 50 years, likely due to increased estrogen exposure, higher ... -
Proliferation, lymph vessel invasion and histologic type as prognostic factors in lymph node negative breast cancer
(Doctoral thesis, 2011-12-14)Breast cancer is a leading cause of cancer mortality among women in the western world, second only to lung cancer. Since the mammography screening program in Norway started in 1995, 70% and more of all new breast cancers ... -
Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation
(Peer reviewed; Journal article, 2017)Introduction: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C ... -
A proper lookout. Studies of contrast sensitivity
(Doctoral thesis, 2018-09-14)Naval navigation and watch keeping in littoral waters is highly dependent on visual function, and all navigators are required to have normal visual acuity (VA) measured by Snellen’s table or equivalent. Although visual ... -
Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative
(Peer reviewed; Journal article, 2019-09-25)Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains ... -
A prospective observational study of why people are medically evacuated from offshore installations in the North Sea
(Journal article; Peer reviewed, 2020)Objectives Few studies have described evacuations due to medical emergencies from the offshore installations in the North Sea, though efficient medical service is essential for the industrial activities in this area. The ... -
Prospective Study of Surgery for Traumatic Brain Injury in Addis Ababa, Ethiopia: Surgical Procedures, Complications, and Postoperative Outcomes
(Journal article; Peer reviewed, 2021)Background Traumatic brain injury (TBI) is an important cause of trauma-related mortality and morbidity in Ethiopia. There are significant resource limitations along the entire continuum of care, and little is known about ... -
Prospective Study of Surgery for Traumatic Brain Injury in Addis Ababa, Ethiopia: Trauma Causes, Injury Types, and Clinical Presentation
(Journal article; Peer reviewed, 2021)Background Traumatic brain injury (TBI) is a public health problem in Ethiopia. More knowledge about the epidemiology and neurosurgical management of TBI patients is needed to identify possible focus areas for quality ... -
Protein intake in children and growth and risk of overweight or obesity: A systematic review and meta-analysis
(Journal article; Peer reviewed, 2022)Objectives: The aim of this study was to examine the evidence for an association between the dietary protein intake in children and the growth and risk of overweight or obesity up to 18 years of age in settings relevant ... -
Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats
(Peer reviewed; Journal article, 2014-08-16)Background It is well known that hypertension may cause glomerular damage, but the molecular mechanisms involved are still incompletely understood. Methods In the present study, we used formalin-fixed paraffin-embedded ... -
Proteomic analysis of total cellular proteins of human neutrophils
(Peer reviewed; Journal article, 2009-08-31)Background: Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ... -
Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease
(Journal article; Peer reviewed, 2023)Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ... -
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers
(Peer reviewed; Journal article, 2019-07-31)Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca ... -
Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN
(Journal article; Peer reviewed, 2022-03-24)Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ... -
Protocol for data extraction: how realworld data have been used in the National Institute for Health and Care Excellence appraisals of cancer therapy
(Journal article; Peer reviewed, 2022)Introduction Due to the limitations of relying on randomised controlled trials, the potential benefits of real-world data (RWD) in enriching evidence for health technology assessment (HTA) are highlighted. Despite increased ... -
Proton pump inhibitors in acid-related diseases. Issues in diagnosis, treatment and outcome
(Doctoral thesis, 2013-06-18)Acid-related disease (ARD) is a term used to describe a range of conditions in which acid is involved in the generation of symptoms and/or complications. Two of the most common ARDs are gastro-esophageal reflux disease ... -
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression
(Journal article; Peer reviewed, 2022)The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its microenvironment is the key driver in this process of tumor progression. ... -
Psoriasis in Norway: A Prescription-based Registry Study of Incidence and Prevalence
(Journal article; Peer reviewed, 2023)Epidemiological data on psoriasis in Norway are limited. The aim of this study was to provide objective national data on the incidence and prevalence of psoriasis. Patients registered in the Norwegian Prescription Database ... -
Psychiatric Comorbidity, Social Aspects and Quality of Life in a Population-Based Cohort of Expecting Fathers with Epilepsy
(Peer reviewed; Journal article, 2015-12-04)Objectives. To investigate psychiatric disorders, adverse social aspects and quality of life in men with epilepsy during partner’s pregnancy. Method. We used data from the Norwegian Mother and Child Cohort Study, including ...