Blar i Department of Clinical Medicine på tittel
Viser treff 1890-1909 av 2045
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Time to halt perioperative chemotherapy for resectable colorectal liver metastasis?
(Journal article; Peer reviewed, 2022) -
Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades
(Peer reviewed; Journal article, 2015-06-05)Norway has been subjected to numerous epidemiological investigations on the prevalence and incidence of multiple sclerosis (MS), dating back to 1935. The objective of this study was to review the studies on the prevalence ... -
The timing of environmental risk factors and prodromal signs of multiple sclerosis
(Doctoral thesis, 2017-12-18)Background: Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system that can lead to severe disability. It is a complex disease likely caused by genetic and environmental factors combined. ... -
Timing of hip hemiarthroplasty and the influence on prosthetic joint infection
(Journal article; Peer reviewed, 2020-03-12)Introduction Previous research suggested that patients have increased risk of infection with increased time from presentation with a femoral neck fracture to treatment with a hip hemiarthroplasty (HHA). The purpose of ... -
Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study.
(Peer reviewed; Journal article, 2015)Background: Low vitamin D levels have been associated with an increased risk of multiple sclerosis (MS), although it remains unknown whether this relationship varies by age. Objective: The objective of this paper is to ... -
Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer
(Peer reviewed; Journal article, 2016-09-13)Hypoxia is frequent in solid tumors and linked to aggressive phenotypes and therapy resistance. We explored expression patterns of the proposed hypoxia marker HIF-1α in endometrial cancer (EC) and investigate whether ... -
The top five research priorities in physician-provided pre-hospital critical care: a consensus report from a European research collaboration
(Peer reviewed; Journal article, 2011-10-13)Background: Physician-manned emergency medical teams supplement other emergency medical services in some countries. These teams are often selectively deployed to patients who are considered likely to require critical care ... -
Topical glaucoma medications – Clinical implications for the ocular surface
(Journal article; Peer reviewed, 2022)Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility ... -
Topography and clinical features of iris melanoma
(Journal article; Peer reviewed, 2022)Background To characterise the topographical and clinical features of primary iris melanoma and to visualise the patterns of tumour extent in the iris. Methods Clinical characteristics of iris melanomas were analysed, ... -
Total drug treatment and comorbidity in myasthenia gravis: a population-based cohort study
(Peer reviewed; Journal article, 2014-04-09)Background and purpose: Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a ... -
Total hip arthroplasties in the Dutch Arthroplasty Register (LROI) and the Nordic Arthroplasty Register Association (NARA): comparison of patient and procedure characteristics in 475,685 cases
(Journal article; Peer reviewed, 2021)Background and purpose — Collaborations between arthroplasty registries are important in order to create the possibility of detecting inferior implants early and improve our understanding of differences between nations in ... -
Total hip replacement in young adults with hip dysplasia. Age at diagnosis, previous treatment, quality of life, and validation of diagnoses reported to the Norwegian Arthroplasty Register between 1987 and 2007
(Peer reviewed; Journal article, 2011-04)Background and purpose: Dysplasia of the hip increases the risk of secondary degenerative change and subsequent total hip replacement. Here we report on age at diagnosis of dysplasia, previous treatment, and quality of ... -
The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients
(Journal article; Peer reviewed, 2023-06-26)Background: Somatic TP53 mutations are frequent in head and neck squamous cell carcinoma (HNSCC) and are important pathogenic factors. Objective: To study TP53 mutations relative to the presence of human papillomavirus ... -
TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma
(Journal article; Peer reviewed, 2024)Introduction: Vulva squamous cell carcinoma (VSCC) develops through two separate molecular pathways—one involving high-risk human papilloma virus infection (HPV-associated), and the other without HPV infection (HPV-independent) ... -
Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
(Peer reviewed; Journal article, 2009-05-20)Background: The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from ... -
Trajectories of psychiatric disorders in a cohort of children with cerebral palsy across four years
(Journal article; Peer reviewed, 2021)Background: Risk of psychiatric disorders has been reported for children and adolescents with cerebral palsy (CP) at different ages, however little is known regarding the long-term trajectories of these disorders. Objective: ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
(Peer reviewed; Journal article, 2016-02-22)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ... -
Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
(Journal article; Peer reviewed, 2023)Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from ... -
Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial
(Peer reviewed; Journal article, 2013-05-23)Background: Transfusion of red blood cells (RBC) is recommended in septic shock and the majority of these patients receive RBC transfusion in the intensive care unit (ICU). However, benefit and harm of RBCs have not been ... -
Transgenerational and intergenerational epigenetic inheritance in allergic diseases
(Peer reviewed; Journal article, 2018-09)It has become clear that early life (including in utero exposures) is a key window of vulnerability during which environmental exposures can alter developmental trajectories and initiate allergic disease development. ...