Now showing items 571-590 of 1392

    • GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study 

      Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019-05-07)
      Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ...
    • GBA2 mutations cause a Marinesco-Sjogren-like syndrome: Genetic and biochemical studies 

      Haugarvoll, Kristoffer; Johansson, Stefan; Rodriguez, Carlos E.; Boman, Helge; Haukanes, Bjørn Ivar; Bruland, Ove; Roque, Francisco; Jonassen, Inge; Blomqvist, Maria; Telstad, Wenche; Månsson, Jan-Eric; Knappskog, Per; Bindoff, Laurence (Peer reviewed; Journal article, 2017-01-04)
      Background: With the advent new sequencing technologies, we now have the tools to understand the phenotypic diversity and the common occurrence of phenocopies. We used these techniques to investigate two Norwegian families ...
    • Gender Differences in Kidney Stone Disease (KSD): Findings from a Systematic Review 

      Gillams, Kathryn; Jones, Patrick; Juliebø, Siri Øvereng; Somani, Bhaskar K. (Journal article; Peer reviewed, 2021)
      Purpose of review: The prevalence of kidney stones is rising and historically carries a preponderance for males. However, recent evidence has questioned whether this gender gap is closing. The aim of this systematic review ...
    • Gene expression alterations in salivary gland epithelia of Sjögren’s syndrome patients are associated with clinical and histopathological manifestations 

      Dela Cruz, Ariana; Kartha, Vinay; Tilston-Lunel, Andrew; Mi, Rongjuan; Reynolds, Taylor L.; Mingueneau, Michael; Monti, Stefano; Jensen, Janicke Liaaen; Skarstein, Kathrine; Varelas, Xaralabos; Kukuruzinska, Maria A. (Journal article; Peer reviewed, 2021)
      Sjögren’s syndrome (SS) is a complex autoimmune disease associated with lymphocytic infiltration and secretory dysfunction of salivary and lacrimal glands. Although the etiology of SS remains unclear, evidence suggests ...
    • Gene expression in the rat brain: High similarity but unique differences between frontomedial-, temporal- and occipital cortex 

      Stansberg, Christine; Ersland, Kari Merete; Valk, Paul van der; Steen, Vidar Martin (Peer reviewed; Journal article, 2011-01-26)
      Background: The six-layered neocortex of the mammalian brain may appear largely homologous, but is in reality a modular structure of anatomically and functionally distinct areas. However, global gene expression seems to ...
    • Gene expression profiles in rat brain disclose CNS signature genes and regional patterns of functional specialisation 

      Stansberg, Christine; Vik-Mo, Audun O.; Holdhus, Rita; Breilid, Harald; Srebro, Boleslaw; Petersen, Kjell; Jørgensen, Hugo A.; Jonassen, Inge; Steen, Vidar Martin (Peer reviewed; Journal article, 2007-04-04)
      Background: The mammalian brain is divided into distinct regions with structural and neurophysiological differences. As a result, gene expression is likely to vary between regions in relation to their cellular composition ...
    • Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains 

      Berg, Kaja Christine Graue; Sveen, Anita; Høland, Maren; Alagaratnam, Sharmini; Rasmussen, Marianne Berg; Danielsen, Stine Aske; Nesbakken, Arild; Søreide, Kjetil; Lothe, Ragnhild A (Peer reviewed; Journal article, 2019-07-15)
      About 80% of colorectal cancers (CRCs) have chromosomal instability, which is an integral part of aggressive malignancy development, but the importance of specific copy number aberrations (CNAs) in modulating gene expression, ...
    • Gene expression profiling of meningiomas: current status after a decade of microarray-based transcriptomic studies 

      Aarhus, Mads; Lund-Johansen, Morten; Knappskog, Per (Peer reviewed; Journal article, 2011-01-14)
      Purpose This article provides a review of the transcriptomic expression profiling studies that have been performed on meningiomas so far. We discuss some future prospects and challenges ahead in the field of gene expression ...
    • Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders 

      Ersland, Kari Merete; Christoforou, Andrea; Stansberg, Christine; Espeseth, Thomas; Mattheisen, Manuel; Mattingsdal, Morten; Hardarson, Gudmundur A.; Hansen, Thomas; Fernandes, Carla P. D.; Giddaluru, Sudheer; Breuer, René; Strohmaier, Jana; Djurovic, Srdjan; Nöthen, Markus M.; Rietschel, Marcella; Lundervold, Astri Johansen; Werge, Thomas; Cichon, Sven; Andreassen, Ole Andreas; Reinvang, Ivar; Steen, Vidar Martin; Le Hellard, Stephanie (Peer reviewed; Journal article, 2012-02-22)
      Background: Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive ...
    • General practitioners' opinions on how to improve treatment of mental disorders in primary health care. Interviews with one hundred Norwegian general practitioners 

      Mykletun, Arnstein; Knudsen, Ann Kristin; Tangen, Tone; Øverland, Simon Nygaard (Peer reviewed; Journal article, 2010-02-09)
      Background: Improvements in treatment of mental disorders are repeatedly called for. General practitioners (GPs) are responsible for the majority of treatment of mental disorders. Consequently, we interviewed GPs about ...
    • Generation of a stepwise prostate carcinogenesis model. A study of epithelial to mesenchymal transition and malignant transformation of prostate primary epithelial cells 

      Qu, Yi (Doctoral thesis; Peer reviewed, 2013-05-29)
      Despite progress in recent years, prostate cancer continues to be one of the most prevalent causes of cancer-related mortality and morbidity in men in Western countries. A major clinical challenge of prostate cancer therapy ...
    • Generic Quality of Life in persons With Hearing Loss: A Systematic Litterature Review 

      Nordvik, Øyvind; Heggdal, Peder Olaf Laugen; Brännstrøm, Jonas; Vassbotn, Flemming; Aarstad, Anne Kari Hersvik; Aarstad, Hans Jørgen (Peer reviewed; Journal article, 2018-01-22)
      Background: To the best of our knowledge, no empirically based consensus has been reached as to if, and to what extent, persons with hearing loss (HL) have reduced generic Quality of life (QoL). There seems to be limited ...
    • Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia 

      Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem; Stordrange, Laila; Jonassen, Inge; Bruserud, Øystein; Kalland, Karl-Henning; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-03-05)
      Background: The molecular changes in vivo in acute myeloid leukemia cells early after start of conventional genotoxic chemotherapy are incompletely understood, and it is not known if early molecular modulations reflect ...
    • Genetic and cellular studies of carboxyl-ester lipase (CEL), a protein involved in exocrine and endocrine pancreatic disease 

      Valvatne, Monica Dalva (Doctoral thesis, 2018-09-13)
      Carboxyl-ester lipase (CEL) is a digestive enzyme mainly expressed in pancreatic acinar cells, from which it is secreted into the duodenum as a component of pancreatic juice. Mutations in the human CEL gene have been linked ...
    • Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer 

      Berg, Marianne; Søreide, Kjetil (Peer reviewed; Journal article, 2011-12-16)
      Colorectal cancer is a major health burden, and a leading cause of cancer-related deaths in industrialized countries. The steady improvements in surgery and chemotherapy have improved survival, but the ability to identify ...
    • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension 

      White, Kevin; Lu, Yu; Annis, Sofia; Hale, Andrew E.; Chau, B. Nelson; Dahlman, James E.; Hemann, Craig; Opotowsky, Alexander R.; Vargas, Sara O.; Rosas, Ivan; Perrella, Mark A.; Osorio, Juan C.; Haley, Kathleen J.; Graham, Brian B.; Kumar, Rahul; Saggar, Rajan; Saggar, Rajeev; Wallace, W. Dean; Ross, David J.; Khan, Omar F.; Bader, Andrew; Gochuico, Bernadette R.; Matar, Majed; Polach, Kevin; Johannessen, Nicolai; Prosser, Haydn M.; Anderson, Daniel G.; Langer, Robert; Zweier, Jay L.; Bindoff, Laurence; Systrom, David; Waxman, Aaron B.; Jin, Richard C.; Chan, Stephen Y. (Peer reviewed; Journal article, 2015)
      Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies ...
    • Genetic associations in myasthenia gravis. Implications for pathogenesis 

      Alseth, Espen Homleid (Doctoral thesis, 2010-11-11)
    • Genetic Risk Factors for Type 2 Diabetes and Related Traits 

      Hertel, Jens Kristoffer (Doctoral thesis, 2012-06-18)
    • Genetic risk of Parkinson disease and progression: An analysis of 13 longitudinal cohorts 

      Iwaki, Hirotaka; Blauwendraat, Cornelis; Leonard, Hampton L.; Liu, Ganqiang; Maple-Grødem, Jodi; Corvol, Jean-Christophe; Pihlstrøm, Lasse; van Nimwegen, Marlies; Hutten, Samantha J.; Nguyen, Khanh-Dung H.; Rick, Jacqueline; Eberly, Shirley; Faghri, Faraz; Auinger, Peggy; Scott, Kirsten M.; Wijeyekoon, Ruwani; van Deerlin, Vivianna M.; Hernandez, Dena G.; Day-Williams, Aaron G.; Brice, Alexis; Alves, Guido Werner; Noyce, Alastair J.; Tysnes, Ole-Bjørn; Evans, Jonathan R.; Breen, David P.; Estrada, Karol; Wegel, Claire E.; Danjou, Fabrice; Simon, David K.; Ravina, Bernard; Toft, Mathias; Heutink, Peter; Bloem, Bastiaan R.; Weintraub, Daniel; Barker, Roger A.; Williams-Gray, Caroline H.; van de Warrenburg, Bart P.; van Hilten, Jacobus J.; Scherzer, Clemens R.; Singleton, Andrew B.; Nalls, Mike A. (Peer reviewed; Journal article, 2019)
      Objective: To determine if any association between previously identified alleles that confer risk for Parkinson disease and variables measuring disease progression. Methods: We evaluated the association between 31 risk ...