Blar i Department of Clinical Medicine på tittel
Viser treff 216-235 av 1089
-
DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder
(Peer reviewed; Journal article, 2012-04-23)Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. ... -
Decompression alone versusdecompression with instrumental fusionthe NORDSTEN degenerativespondylolisthesis trial (NORDSTEN-DS); study protocol for a randomized controlled trial
(Peer reviewed; Journal article, 2019-01-05)Background: Fusion in addition to decompression has become the standard treatment for lumbar spinal stenosis with degenerative spondylolisthesis (DS). The evidence for performing fusion among these patients is conflicting ... -
Default-mode network functional connectivity is closely related to metabolic activity
(Peer reviewed; Journal article, 2015-06)Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ... -
Defective i⁶A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA
(Peer reviewed; Journal article, 2014-06-05)Identifying the genetic basis for mitochondrial diseases is technically challenging given the size of the mitochondrial proteome and the heterogeneity of disease presentations. Using next-generation exome sequencing, we ... -
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
(Peer reviewed; Journal article, 2016-11-22)Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ... -
Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta
(Peer reviewed; Journal article, 2014-02-19)Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ... -
Deformation and initial stability in hip arthroplasty. Effect of neck geometry and fixation – an experimental cadaver study
(Doctoral thesis, 2017-06-08)Introduction: The search for and development of the optimal joint implant include preclinical testing. Restoration of the individual and natural biomechanics in the hip joint is a central goal in hip arthroplasty, and can ... -
Demens med Lewylegemer: søvn, kognisjon og nevropatologi
(Doctoral thesis, 2019-01-17)Background Sleep disorders are frequent in patients with dementia. Sleep disturbances can negatively influence the disease burden of dementia and accelerate the rate of cognitive decline. It is hypothesized that sleep ... -
Dementia with Lewy Bodies. Identification, frequency and sleep-disturbances. A cross-sectional clinical dementia cohort study
(Doctoral thesis, 2011-02-18)Background: Dementia with Lewy Bodies (DLB) has existed as a formal consensus diagnosis since 1996 and is defined by dementia and the core features parkinsonism, visual hallucinations and cognitive fluctuations. The original ... -
Densities of rectal peptide YY and somatostatin cells as biomarkers for the diagnosis of irritable bowel syndrome
(Peer reviewed; Journal article, 2015-03-09)Irritable bowel syndrome (IBS) is a common chronic disorder. IBS diagnosis is a diagnosis of exclusion since there are no blood tests, radiological or endoscopic examinations for this disorder. Although several attempts ... -
Depresjon og andre subjektive helseplager hos pasientar med korsryggsmerter. Har inntak av sjømat og vitamin D-status noko betyding?
(Master thesis, 2014-05-15)Background: Vitamin D is found in limited selections of food, among other fatty fish and fish liver, as well as fortified food such as margarine and milk. Other vitamin D sources are dietary supplements and sunlight. Low ... -
Depression and migraine comorbid to diabetes
(Doctoral thesis, 2014-12-04)Background: Diabetes, depression and migraine are prevalent diseases in the Norwegian population, and have great impact on patients life in terms of disability. Diabetes is a systemic disease manifesting in a range of organ ... -
Depression in Parkinson’s disease
(Doctoral thesis, 2010-05-07) -
Depressive symptoms in psychotic disorders : Trajectories of depression and antidepressive effectiveness of antipsychotic medication
(Doctoral thesis, 2020-10-16)Background: Depressive symptoms are common in psychotic disorders and contribute to impaired functioning, a poorer quality of life, elevated relapse rate and suicide risk. Depression in schizophrenia may emerge as part of ... -
Determinants of vitamin D status
(Master thesis, 2020-06-27) -
Determining universal processes related to best outcome in emergency abdominal surgery: A multicentre, international, prospective cohort study
(Peer reviewed; Journal article, 2014-10-29)Introduction: Emergency abdominal surgery outcomes represent an internationally important marker of healthcare quality and capacity. In this study, a novel approach to investigating global surgical outcomes is proposed, ... -
Developing a novel femoral stem in hip arthroplasty. An innovation process using a weight-bearing animal model
(Doctoral thesis, 2015-08-20)Introduction: To address the growing incidence of hip replacement revision, this project aimed to find a stem that would fulfil three criteria. First, solid osteointegration and long survival of the implant. Second, easy ... -
Developing a rodent model for antipsychotic-induced metabolic adverse effects
(Doctoral thesis, 2012-04-20)Antipsychotic agents represent efficient therapy for serious psychiatric disorders, particularly schizophrenia, but also bipolar disorder, and are used by millions of patients worldwide. Metabolic adverse effects of ... -
Developing nephrology services in low income countries: A case of Tanzania
(Peer reviewed; Journal article, 2019-10-17)Background: The burden of kidney diseases is reported to be higher in lower- and middle-income countries as compared to developed countries, and countries in sub-Saharan Africa are reported to be most affected. Health ... -
Diagnostic accuracy of a short endoscopic secretin test in patients with cystic fibrosis
(Peer reviewed; Journal article, 2015-02-16)Objective: Short endoscopic secretin tests for exocrine pancreatic function are not properly evaluated in cystic fibrosis (CF). Methods: Patients with CF and healthy controls (HCs) underwent endoscopic collection of duodenal ...