dc.contributor.author | Panja, Debabrata | en_US |
dc.contributor.author | Kenney, Justin W. | en_US |
dc.contributor.author | D'Andrea, Laura | en_US |
dc.contributor.author | Zalfa, Francesca | en_US |
dc.contributor.author | Vedeler, Anni | en_US |
dc.contributor.author | Wibrand, Karin | en_US |
dc.contributor.author | Fukunaga, Rikiro | en_US |
dc.contributor.author | Bagni, Claudia | en_US |
dc.contributor.author | Proud, Christopher G. | en_US |
dc.contributor.author | Bramham, Clive R. | en_US |
dc.date.accessioned | 2015-03-17T13:23:39Z | |
dc.date.available | 2015-03-17T13:23:39Z | |
dc.date.issued | 2014-11-20 | eng |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | https://hdl.handle.net/1956/9548 | |
dc.description.abstract | BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-TrkB signaling. Surprisingly, this sustained activation maintains an otherwise labile signaling pathway from TrkB to MAP-kinase-interacting kinase (MNK). MNK activity promotes eIF4F translation initiation complex formation and protein synthesis in mechanistically distinct early and late stages. In early-stage translation, MNK triggers release of the CYFIP1/FMRP repressor complex from the 5′-mRNA cap. In late-stage translation, MNK regulates the canonical translational repressor 4E-BP2 in a synapse-compartment-specific manner. This late stage is coupled to MNK-dependent enhanced dendritic mRNA translation. We conclude that LTP consolidation in the dentate gyrus is mediated by sustained BDNF signaling to MNK and MNK-dependent regulation of translation in two functionally and mechanistically distinct stages. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Cell Press | eng |
dc.rights | Attribution-NonCommercial-NoDerivs CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | eng |
dc.title | Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-03-04T09:51:00Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 The Authors | |
dc.identifier.doi | https://doi.org/10.1016/j.celrep.2014.10.016 | |
dc.identifier.cristin | 1217052 | |
dc.source.journal | Cell reports | |
dc.source.40 | 9 | |
dc.source.14 | 4 | |
dc.source.pagenumber | 1430-1445 | |
dc.subject.nsi | VDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical biochemistry: 726 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726 | nob |