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Parenteral Vaccination against Influenza Does Not Induce a Local Antigen-Specific Immune Response in the Nasal Mucosa

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dc.contributor.author Brokstad, Karl Albert
dc.contributor.author Eriksson, Jens-Christian Haug
dc.contributor.author Cox, Rebecca Jane
dc.contributor.author Tynning, Turid Liv
dc.contributor.author Olofsson, Jan
dc.contributor.author Jonsson, Roland
dc.contributor.author Davidsson, Åke
dc.date.accessioned 2009-09-14T12:42:14Z
dc.date.available 2009-09-14T12:42:14Z
dc.date.issued 2002-03-19
dc.identifier.citation The Journal of Infectious Diseases 185(7): 878-884 en
dc.identifier.issn 0022-1899
dc.identifier.uri http://dx.doi.org/10.1086/339710
dc.identifier.uri http://hdl.handle.net/1956/3452
dc.description.abstract The immune response in the nasal mucosa to influenza vaccination in 23 patients scheduled for tonsillectomy was studied. A statistically significant increase in influenza virus–specific serum and oral fluid antibodies was observed 7 days after vaccination. The numbers of influenza virus– specific antibody-secreting cells (ASCs) in peripheral blood also increased significantly 1 week after vaccination. The numbers of ASCs in tonsils and nasal mucosa were compared with data from a recent study of nonvaccinated volunteers. The numbers of influenza virus–specific ASCs in tonsils were significantly higher in the vaccinated group, but, surprisingly, there was no significant difference between the groups in the numbers of ASCs in nasal mucosa. This suggests that the influenza virus–specific antibodies detected in oral fluid are not produced locally in the nasal mucosa and may originate from a systemic source, indicating that the vaccination may favor a systemic immune response. en
dc.language.iso eng en
dc.publisher University of Chicago Press en
dc.title Parenteral Vaccination against Influenza Does Not Induce a Local Antigen-Specific Immune Response in the Nasal Mucosa en
dc.type Journal article en
dc.type Peer reviewed en
dc.subject.nsi VDP::Medisinske Fag: 700 no
dc.rightsHolder The Infectious Diseases Society of America
dc.type.version Published version en
bora.cristinID 400390


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