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dc.contributor.authorBrokstad, Karl Alberteng
dc.contributor.authorEriksson, Jens-Christian Haugeng
dc.contributor.authorCox, Rebecca Janeeng
dc.contributor.authorTynning, Turid Liveng
dc.contributor.authorOlofsson, Janeng
dc.contributor.authorJonsson, Rolandeng
dc.contributor.authorDavidsson, Åkeeng
dc.date.accessioned2009-09-14T12:42:14Z
dc.date.available2009-09-14T12:42:14Z
dc.date.issued2002-03-19eng
dc.identifier.citationThe Journal of Infectious Diseases 185(7): 878-884en
dc.identifier.issn0022-1899eng
dc.identifier.urihttp://hdl.handle.net/1956/3452
dc.description.abstractThe immune response in the nasal mucosa to influenza vaccination in 23 patients scheduled for tonsillectomy was studied. A statistically significant increase in influenza virus–specific serum and oral fluid antibodies was observed 7 days after vaccination. The numbers of influenza virus– specific antibody-secreting cells (ASCs) in peripheral blood also increased significantly 1 week after vaccination. The numbers of ASCs in tonsils and nasal mucosa were compared with data from a recent study of nonvaccinated volunteers. The numbers of influenza virus–specific ASCs in tonsils were significantly higher in the vaccinated group, but, surprisingly, there was no significant difference between the groups in the numbers of ASCs in nasal mucosa. This suggests that the influenza virus–specific antibodies detected in oral fluid are not produced locally in the nasal mucosa and may originate from a systemic source, indicating that the vaccination may favor a systemic immune response.en
dc.language.isoengeng
dc.publisherUniversity of Chicago Presseng
dc.titleParenteral Vaccination against Influenza Does Not Induce a Local Antigen-Specific Immune Response in the Nasal Mucosaeng
dc.typeJournal articleeng
dc.typePeer reviewedeng
dc.subject.nsiVDP::Medisinske Fag: 700nob
dc.rights.holderThe Infectious Diseases Society of Americaeng
dc.type.versionPublished versioneng
bora.peerreviewedPeer reviewedeng
bora.cristinID400390eng
bibo.doihttp://dx.doi.org/10.1086/339710eng
dc.identifier.cristinID400390eng
dc.identifier.doihttp://dx.doi.org/10.1086/339710


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