• Impact of aortic valve stenosis on myocardial deformation in different left ventricular levels: A three-dimensional speckle tracking echocardiography study 

      Hjertaas, Johannes Just; Einarsen, Eigir; Gerdts, Eva; Kokorina, Marina Victorovna; Moen, Christian Arvei; Urheim, Stig; Saeed, Sahrai; Matre, Knut (Journal article; Peer reviewed, 2023)
      Background: Global systolic left ventricular (LV) myocardial function progressively declines as degenerative aortic valve stenosis (AS) progresses. Whether this results in uniformly distributed deformation changes from ...
    • Impact of arterio–ventricular interaction on first-phase ejection fraction in aortic stenosis 

      Einarsen, Eigir; Hjertaas, Johannes Just; Gu, Haotian; Matre, Knut; Chowienczyk, Philip J.; Gerdts, Eva; Chambers, John B.; Saeed, Sahrai (Peer reviewed; Journal article, 2020)
      Aims:  First-phase ejection fraction (EF1), the EF at the time to peak aortic jet velocity, has been proposed as a novel marker of peak systolic function in aortic stenosis (AS). This study aimed to explore the association ...
    • Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: Position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart 

      Perrino, Cinzia; Ferdinandy, Péter; Bøtker, Hans Erik; Brundel, Bianca J. J. M; Collins, Peter; Davidson, Sean M; Den Ruijter, Hester M.; Engel, Felix B.; Gerdts, Eva; Girao, Henrique; Gyöngyösi, Mariann; Hausenloy, Derek J.; Lecour, Sandrine; Madonna, Rosalinda; Marber, Michael; Murphy, Elizabeth; Pesce, Maurizio; Regitz-Zagrosek, Vera; Sluijter, Joost P.G.; Steffens, Sabine; Gollmann-Tepeköylü, Can; Van Laake, Linda W.; Van Linthout, Sophie; Schulz, Rainer; Ytrehus, Kirsti (Journal article; Peer reviewed, 2021)
      Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and morbidity in both men and women. Sex, however, affects several aspects of IHD, including pathophysiology, incidence, clinical presentation, ...
    • Inflammation, sex, blood pressure changes and hypertension in midlife: the Hordaland Health Study 

      Kringeland, Ester Anne; Gerdts, Eva; Ulvik, Arve; Tell, Grethe S.; Igland, Jannicke; Haugsgjerd, Teresa Risan; Ueland, Per Magne; Midtbø, Helga Bergljot (Journal article; Peer reviewed, 2022)
      Our aim was to test sex-specific associations of circulating markers of inflammation with blood pressure (BP) and incident hypertension in midlife. Participants in the Hordaland Health study (n = 3280, 56% women, mean age ...
    • Left ventricular hypertrophy contributes to Myocardial Ischemia in Non-obstructive Coronary Artery Disease (the MicroCAD study) 

      Eskerud, Ingeborg; Gerdts, Eva; Larsen, Terje H; Lønnebakken, Mai Tone (Peer reviewed; Journal article, 2019)
      Background: The underlying mechanisms causing myocardial ischemia in non-obstructive coronary artery disease (CAD) are still unclear. We explored whether left ventricular hypertrophy (LVH) was associated with myocardial ...
    • Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study 

      Sharashova, Ekaterina; Wilsgaard, Tom; Ball, Jocasta; Morseth, Bente; Gerdts, Eva; Hopstock, Laila Arnesdatter; Mathiesen, Ellisiv B.; Schirmer, Henrik; Løchen, Maja-Lisa (Peer reviewed; Journal article, 2019)
      Aims: To explore sex-specific associations between long-term individual blood pressure (BP) patterns and risk of incident atrial fibrillation (AF) in the general population. Methods and results: Blood pressure was measured ...
    • Low myocardial energetic efficiency is associated with increased mortality in aortic stenosis 

      Bahlmann, Edda; Einarsen, Eigir; Cramariuc, Dana; Midtbø, Helga Bergljot; Mancusi, Costatino; Rossebø, Anne Bjørhovde; Willems, Stephan; Gerdts, Eva (Journal article; Peer reviewed, 2021)
      Objectives In hypertension, low myocardial energetic efficiency (MEEi) has been documented as an integrated marker of metabolic and left ventricular (LV) myocardial dysfunction. We tested the predictive performance of MEEi ...
    • Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery 

      Kovac, Nina; Grymyr, Lisa Marie Dale; Gerdts, Eva; Nadirpour, Saied; Nedrebø, Bjørn Gunnar; Hjertaas, Johannes Just; Matre, Knut; Cramariuc, Dana (Journal article; Peer reviewed, 2022)
      Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis ...
    • Masked hypertension in obesity: Potential predictors and arterial damage 

      Kenny, Isabel E.; Saeed, Sahrai; Gerdts, Eva; Midtbø, Helga Bergljot; Halland, Hilde; Lønnebakken, Mai Tone (Peer reviewed; Journal article, 2017-02)
      Background: Masked hypertension (MHT), defined as normal office blood pressure (BP) but high ambulatory BP, has been associated with increased cardiovascular risk. Although MHT has been associated with obesity, there is ...
    • Myocardial function in aortic stenosis - insights from radial multilayer Doppler strain 

      Cramariuc, Dana; Gerdts, Eva; Hjertaas, Johannes Just; Cramariuc, Alexandru; Davidsen, Einar Skulstad; Matre, Knut (Peer reviewed; Journal article, 2015-02-19)
      Background Left ventricular (LV) radial tissue Doppler imaging (TDI) strain increases gradually from the subepicardial to the subendocardial layer in healthy individuals. A speckle tracking echocardiography study suggested ...
    • Myocardial Work in Middle-Aged Adults with Overweight and Obesity: Associations with Sex and Central Arterial Stiffness 

      Lindseth, Katrine Tryti; Gerdts, Eva; Midtbø, Helga Bergljot; Pristaj, Nadia; Cramariuc, Dana; Einarsen, Eigir (Journal article; Peer reviewed, 2023)
      We explored global myocardial work index (GWI), a novel measure of myocardial function that integrates left ventricular (LV) hemodynamic load, in relation to sex and increased body mass index (BMI). We used data from 467 ...
    • New Evidence About Aortic Valve Stenosis and Cardiovascular Hemodynamics 

      Mancusi, Costantino; Bahlmann, Edda; Basile, Christian; Gerdts, Eva (Journal article; Peer reviewed, 2022)
      Aortic stenosis (AS) is the most common degenerative valvular disease in western word. In patients with severe AS, small changes in aortic valve area can lead to large changes in hemodynamics. The correct understanding of ...
    • The Norwegian Stroke in the Young Study (NOR-SYS): rationale and design 

      Fromm, Annette; Thomassen, Lars; Næss, Halvor; Meijer, Rudy; Eide, Geir Egil; Kråkenes, Jostein; Vedeler, Christian A.; Gerdts, Eva; Larsen, Terje H.; Kuiper, Karel Kier-Jan; Laxdal, Elin Hanna; Russell, David; Tatlisumak, Turgut; Waje-Andreassen, Ulrike (Peer reviewed; Journal article, 2013-07-17)
      Background: Ischemic stroke in young adults is a major health problem being associated with a higher vascular morbidity and mortality compared to controls, and a stroke recurrence rate of 25% during the first decade. The ...
    • One-year impact of bariatric surgery on left ventricular mechanics: results from the prospective FatWest study 

      Grymyr, Lisa Marie Dale; Nadirpour, Saied; Gerdts, Eva; Nedrebø, Bjørn Gunnar; Hjertaas, Johannes Just; Matre, Knut; Cramariuc, Dana (Journal article; Peer reviewed, 2021)
      Aims Patients with severe obesity are predisposed to left ventricular (LV) hypertrophy, increased myocardial oxygen demand, and impaired myocardial mechanics. Bariatric surgery leads to rapid weight loss and improves ...
    • Persistent cardiac organ damage in surgically and medically treated primary aldosteronism 

      Aune, Arleen; Gerdts, Eva; Kokorina, Marina Victorovna; Kringeland, Ester Anne; Midtbø, Helga Bergljot; Løvås, Kristian; Grytaas, Marianne (Journal article; Peer reviewed, 2022)
      Objective: We compared persistent cardiac organ damage in patients treated surgically or medically for primary aldosteronism. Methods: Eighty-four patients (age 57 ± 11 years, 27% women) with primary aldosteronism ...
    • Preclinical cardiac disease in women and men with primary aldosteronism 

      Aune, Arleen; Kokorina, Marina Victorovna; Grytaas, Marianne Aa.; Midtbø, Helga Bergljot; Løvås, Kristian; Gerdts, Eva (Journal article; Peer reviewed, 2021)
      Purpose: We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods: Conventional and speckle tracking ...
    • Prognosis in asymptomatic patients with discordantly graded aortic valve stenosis based on pressure recovery adjusted valve area 

      Bahlmann, Edda; Einarsen, Eigir; Cramariuc, Dana; Pedersen, Eva Ringdal; Rossebø, Anne Bjørhovde; Midtbø, Helga Bergljot; Willems, Stephan; Gerdts, Eva (Journal article; Peer reviewed, 2022)
      Objective: We hypothesised that patients with asymptomatic aortic stenosis (AS) who remain with discordantly graded aortic valve stenosis (DGAS) after adjustment for pressure recovery in the aortic root represents a subgroup ...
    • Relation of Left Ventricular Mass to Prognosis in Initially Asymptomatic Mild to Moderate Aortic Valve Stenosis 

      Gerdts, Eva; Rossebø, Anne Bjørhovde; Pedersen, Terje Rolf; Cioffi, Giovanni; Lønnebakken, Mai Tone; Cramariuc, Dana; Rogge, Barbara; Devereux, Richard B (Peer reviewed; Journal article, 2015)
      Background—The prognostic importance of left ventricular (LV) mass in nonsevere asymptomatic aortic stenosis has not been documented in a large prospective study. Methods and Results—Cox regression analysis was used to ...
    • Right atrium and cryptogenic ischaemic stroke in the young: A case-control study 

      Pöyhönen, Pauli; Kuusisto, Jouni; Pirinen, Jani; Räty, Heli; Lehmonen, Lauri; Paakkanen, Riitta; Martinez-Majander, Nicolas; Gerdts, Eva; Putaala, Jukka; Sinisalo, Juha; Järvinen, Vesa (Journal article; Peer reviewed, 2021)
      Background Recent studies suggest left atrial (LA) dysfunction in cryptogenic stroke. We studied the dynamics of right atrium (RA) and right atrial appendage (RAA) in young adults with cryptogenic stroke. We hypothesised ...
    • Sex differences in arterial hypertension 

      Gerdts, Eva; Sudano, Isabella; Brouwers, Sofie; Borghi, Claudio; Bruno, RM; Ceconi, Claudio; Cornelissen, Veronique; Dievart, Francois; Ferrini, Marc; Kahan, Thomas; Løchen, Maja-Lisa; Maas, Angela H.E.M.; Mahfoud, Felix; Mihailidou, Anastasia Susie; Moholdt, Trine; Parati, Gianfranco; de Simone, Giovanni (Journal article; Peer reviewed, 2022)
      There is strong evidence that sex chromosomes and sex hormones influence blood pressure (BP) regulation, distribution of cardiovascular (CV) risk factors and co-morbidities differentially in females and males with essential ...