Blar i Department of Biomedicine på forfatter "Bramham, Clive Raymond Evjen"

Viser treff 1-8 av 8

    • Activation-induced chromatin reorganization in neurons depends on HDAC1 activity 

      Grabowska, Agnieszka; Sas-Nowosielska, Hanna; Wojtas, Bartosz; Holm-Kaczmarek, Dagmara; Januszewicz, Elzbieta; Yushkevich, Yana; Czaban, Iwona; Trzaskoma, Pawel; Krawczyk, Katarzyna; Gielniewski, Bartlomiej; Martin-Gonzalez, Ana; Filipkowski, Robert Kuba; Olszynski, Krzysztof Hubert; Bernas, Tytus; Szczepankiewicz, Andrzej Antoni; Sliwinska, Malgorzata Alicja; Kanhema, Tambudzai; Bramham, Clive Raymond Evjen; Bokota, Grzegorz; Plewczynski, Dariusz; Wilczynski, Grzegorz Marek; Magalska, Adriana (Journal article; Peer reviewed, 2022)
      Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that ...

    • Antidepressant drugs act by directly binding to TRKB neurotrophin receptors 

      Casarotto, Plinio C.; Girych, Mykhailo; Fred, Senem M.; Kovaleva, Vera; Moliner, Rafael; Enkavi, Giray; Biojone, Caroline; Cannarozzo, Cecilia; Sahu, Madhusmita Pryiadrashini; Kaurinkoski, Katja; Brunello, Cecilia A.; Steinzeig, Anna; Winkel, Frederike; Patil, Sudarshan; Vestring, Stefan; Serchov, Tsvetan; Diniz, Cassiano R.A.F.; Laukkanen, Liina; Cardon, Iseline; Antila, Hanna; Rog, Tomasz; Piepponen, Timo Petteri; Bramham, Clive Raymond Evjen; Normann, Claus; Lauri, Sari E.; Saarma, Mart; Vattulainen, Ilpo; Castrén, Eero (Journal article; Peer reviewed, 2021)
      It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived ...

    • Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc 

      Hallin, Erik Ingmar; Markusson, Sigurbjörn; Bottger, Lev; Torda, Andrew E.; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms ...

    • Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo 

      Mergiya, Tadiwos Feyissa; Gundersen, Jens Edvard Trygstad; Kanhema, Tambudzai; Brighter, Grant Mitchell; Ishizuka, Yuta; Bramham, Clive Raymond Evjen (Journal article; Peer reviewed, 2023)
      The immediate early gene product activity-regulated cytoskeleton-associated protein (Arc or Arg3.1) is a major regulator of long-term synaptic plasticity with critical roles in postnatal cortical development and memory ...

    • Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function 

      Ishizuka, Yuta; Mergiya, Tadiwos Feyissa; Baldinotti, Rodolfo Da Silva Mazzarini; Xu, Ju; Hallin, Erik Ingmar; Markusson, Sigurbjörn; Kursula, Petri; Bramham, Clive Raymond Evjen (Journal article; Peer reviewed, 2022)
      Activity-regulated cytoskeleton-associated (Arc) protein plays key roles in long-term synaptic plasticity, memory, and cognitive flexibility. However, an integral understanding of Arc mechanisms is lacking. Arc is proposed ...

    • Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines 

      Acuña-Hinrichsen, Francisca; Covarrubias-Pinto, Adriana; Ishizuka, Yuta; Stolzenbach, María Francisca; Martin, Carolina; Salazar, Paula; Castro, Maite A.; Bramham, Clive Raymond Evjen; Otth, Carola (Journal article; Peer reviewed, 2021)
      Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. ...

    • High-affinity anti-Arc nanobodies provide tools for structural and functional studies 

      Markusson, Sigurbjörn; Hallin, Erik Ingmar; Bustad, Helene J.; Raasakka, Arne; Xu, Ju; Muruganandam, Gopinath; Loris, Remy; Martinez, Aurora; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2022)
      Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals. However, the mechanistic ...

    • Structural properties and peptide ligand binding of the capsid homology domains of human Arc 

      Hallin, Erik Ingmar; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)
      The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its ...