Blar i Department of Biomedicine på forfatter "Muga, Arturo"
-
Conformational Sampling and Nucleotide-Dependent Transitions of the GroEL Subunit Probed by Unbiased Molecular Dynamics Simulations
Skjærven, Lars; Grant, Barry; Muga, Arturo; Teigen, Knut; McCammon, J. Andrew; Reuter, Nathalie; Martinez, Aurora (Peer reviewed; Journal article, 2011-03-10)GroEL is an ATP dependent molecular chaperone that promotes the folding of a large number of substrate proteins in E. coli. Large-scale conformational transitions occurring during the reaction cycle have been characterized ... -
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach
Dublang, Leire; Underhaug, Jarl; Flydal, Marte Innselset; Velasco-Carneros, Lorea; Maréchal, Jean-Didier; Moro, Fernando; Boyano, Maria Dolores; Martinez, Aurora; Muga, Arturo (Journal article; Peer reviewed, 2021)Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ...