Blar i Department of Clinical Medicine på forfatter "Blaser, Nello"
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Optimization of receptor occupancy assays in mass cytometry: Standardization across channels with QSC beads
Bringeland, Gerd Haga; Bader, Lucius; Blaser, Nello; Budzinski, Lisa; Schulz, Axel R.; Mei, Henrik E.; Myhr, Kjell-Morten; Vedeler, Christian A.; Gavasso, Sonia (Peer reviewed; Journal article, 2019)Receptor occupancy, the ratio between amount of drug bound and amount of total receptor on single cells, is a biomarker for treatment response to therapeutic monoclonal antibodies. Receptor occupancy is traditionally ... -
Wearing-off at the end of natalizumab dosing intervals is associated with low receptor occupancy
Bringeland, Gerd Haga; Blaser, Nello; Myhr, Kjell-Morten; Vedeler, Christian A.; Gavasso, Sonia (Journal article; Peer reviewed, 2020-02)Objective: We aimed to investigate whether wearing-off symptoms at the end of the natalizumab dosing interval were associated with clinical and demographic patient characteristics or natalizumab receptor occupancy (RO) on ...