Blar i Bergen Open Research Archive på tittel
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Identification of genetic loci shared between schizophrenia and the Big Five personality traits
(Peer reviewed; Journal article, 2017-05-22)Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between ... -
Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder
(Peer reviewed; Journal article, 2019)Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, ... -
Identification of host biomarkers from dried blood spots for monitoring treatment response in extrapulmonary tuberculosis
(Journal article; Peer reviewed, 2023)There is a lack of objective tools for monitoring treatment response in extrapulmonary tuberculosis (EPTB). This study aimed to explore the utility of inflammatory biomarkers from the dry blood spots (DBS) as a tool for ... -
Identification of housekeeping genes of Candidatus Branchiomonas cysticola associated with epitheliocystis in Atlantic salmon (Salmo salar L.)
(Journal article; Peer reviewed, 2022)Candidatus Branchiomonas cysticola is an intracellular, gram-negative Betaproteobacteria causing epitheliocystis in Atlantic Salmon (Salmo salar L.). The bacterium has not been genetically characterized at the intraspecific ... -
Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis
(Journal article; Peer reviewed, 2020)Background: The tumor microenvironment (TME) of human glioblastoma (GBM) exhibits considerable immune cell infiltration, and such cell types have been shown to be widely involved in the development of GBM. Here, weighted ... -
Identification of immunogenic surface proteins of Pasteurella atlantica genomovar salmonicida
(Master thesis, 2023-06-02) -
Identification of in vivo induced antigens of the malacosporean parasite Tetracapsuloides bryosalmonae (Cnidaria) using in vivo induced antigen technology
(Journal article; Peer reviewed, 2022)Tetracapsuloides bryosalmonae is a malacosporean endoparasite that causes proliferative kidney disease (PKD) in wild and farmed salmonids in Europe and North America. The life cycle of T. bryosalmonae completes between ... -
Identification of inhibitors of tryptophan hydroxylase 1
(Master thesis, 2014-05-20)Background: In this study we use molecular docking to find compounds that interact with the enzyme tryptophan hydroxylase (TPH), followed by experimental validation. TPH is a tetrahydrobiopterin (BH4) dependent enzyme that ... -
Identification of key components in the energy metabolism of Archaeoglobus fulgidus by transcriptome analyses
(Peer reviewed; Journal article, 2014-03-11)Energy conservation via the pathway of dissimilatory sulfate reduction is present in a diverse group of prokaryotes, but is most comprehensively studied in Deltaproteobacteria. In this study, whole-genome microarray analyses ... -
Identification of microRNAs from medicinal plant Murraya Koenigii by high-throughput sequencing and their functional implications in secondary metabolite biosynthesis
(Journal article; Peer reviewed, 2022)MicroRNAs (miRNAs) are small noncoding RNA molecules that play crucial post-transcriptional regulatory roles in plants, including development and stress-response signaling. However, information about their involvement in ... -
Identification of nine new susceptibility loci for endometrial cancer
(Peer reviewed; Journal article, 2018-08-09)Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial ... -
Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
(Journal article; Peer reviewed, 2023)Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity and overlapping symptoms. However, the causative mechanisms underlying this relationship are poorly understood. Here we aimed to ... -
Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms
(Peer reviewed; Journal article, 2015-07-02)Background: Human T cell leukemia virus type 1 (HTLV-1) gene expression is controlled by the key regulatory proteins Tax and Rex. The concerted action of these proteins results in a two-phase kinetics of viral expression ... -
Identification of pharmacological chaperones for Phenylalanine Hydroxylase. A virtual screening approach to discover novel drug candidates for treatment of phenylketonuria
(Master thesis, 2014-05-20)Phenylalanine hydroxylase (PAH) is an enzyme that catalyses the hydroxylation of phenylalanine into tyrosine in the liver, which is the rate-limiting step in phenylalanine catabolism. PAH is a non-heme iron-dependent enzyme ... -
Identification of pleiotropy at the gene level between psychiatric disorders and related traits
(Journal article; Peer reviewed, 2021)Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) ...