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    • Novel 3D Pixel Sensors for the Upgrade of the ATLAS Inner Tracker 

      Terzo, Stefano; Boscardin, Maurizio; Carlotto, Juan; Dalla Betta, Gian-Franco; Darbo, Giovanni; Dorholt, Ole; Ficorella, Francesco; Gariano, G; Gemme, Claudia; Giannini, Giulia; Grinstein, S; Heggelund, Andreas; Huiberts, Simon Kristian; Kok, Angela; Koybasi, Ozhan; Lapertosa, Alessandro; Lauritzen, Magne Eik; Manna, Maria; Mendicino, Roberto; Oide, Hideyuki; Pellegrini, Giulio; Povoli, Marco; Quirion, David; Røhne, Ole Myren; Ronchin, S; Sandaker, Heidi; Abdulla Samy, Md. Arif; Stugu, Bjarne Sandvik; Vannoli, Leonardo (Journal article; Peer reviewed, 2021)
      The ATLAS experiment will undergo a full replacement of its inner detector to face the challenges posed by the High Luminosity upgrade of the Large Hadron Collider (HL-LHC). The new Inner Tracker (ITk) will have to deal ...

    • A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer 

      Ingebriktsen, Lise Martine; Finne, Kenneth; Akslen, Lars Andreas; Wik, Elisabeth (Journal article; Peer reviewed, 2022)
      Background and objective Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC ...

    • A novel approach to co-expression network analysis identifies modules and genes relevant for moulting and development in the Atlantic salmon louse (Lepeophtheirus salmonis) 

      Zhou, Zhaoran; Eichner, Christiane; Nilsen, Frank; Jonassen, Inge; Dondrup, Michael (Journal article; Peer reviewed, 2021)
      Background The salmon louse (Lepeophtheirus salmonis) is an obligate ectoparasitic copepod living on Atlantic salmon and other salmonids in the marine environment. Salmon lice cause a number of environmental problems and ...

    • A novel approach to construct self-assembled 3D MEMS arrays 

      Akhundzada, Sapida; Yang, Xiaohui; Fiedler, Johannes; Käkel, Eireen; Al-Qargholi, Basim; Buhmann, Stefan; Ehresmann, Arno; Hillmer, Hartmut (Journal article; Peer reviewed, 2022)
      The paper presents the design and technological fabrication process of Yin or Yang-shaped, micron-sized electromechanical system (MEMS) elements displaying asymmetric hollow cylinders with two different curvatures of the ...

    • A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium 

      Slimestad, Rune; Rathe, Bendik Auran; Aesoy, Reidun; Diaz, Andrea Estefania Carpinteyro; Herfindal, Lars; Fossen, Torgils (Journal article; Peer reviewed, 2022)
      Garden chervil, Anthriscus cerefolium (L.) Hoffm. is an important herb commonly applied in Norwegian large-scale commercial kitchens. This species is a highly enriched source of phenolics, containing 1260 mg gallic acid ...

    • A novel case of impaired C-reactive protein response following open-heart surgery: A case report and review of the literature 

      Vinnes, Erik Wilhelm; Lillemoen, Paul Kjetil Soldal; Persson, Robert; Meyer, Klaus; Haaverstad, Rune; Monsen, Anne-Lise Bjørke (Journal article; Peer reviewed, 2021)
      Background C-reactive protein (CRP) is expected to increase in response to a range of inflammatory stimuli such as infections or extensive tissue trauma. Case report We present a novel case of severely impaired CRP ...

    • Novel clearance of muscle proteins by muscle cells 

      Muslimovic, Aida; Friden, Vincent; Starnberg, Karin; Tenstad, Olav; Espedal, Heidi; Vukusic, Kristina; Nyström, Susanne; Wesén, Emelie; Esbjörner, Elin K; Granholm, Kristoffer; Lindahl, Bertil; Hammarsten, Ola (Journal article; Peer reviewed, 2020)
      Blood levels of cardiac troponins (cTn) and myoglobin are analysed when myocardial infarction (MI) is suspected. Here we describe a novel clearance mechanism for muscle proteins by muscle cells. The complete plasma clearance ...

    • A novel concentrated, interdisciplinary group rehabilitation program for patients with chronic obstructive pulmonary disease: Protocol for a nonrandomized clinical intervention study 

      Frisk, Bente; Njøten, Kiri Lovise; Aarli, Bernt Bøgvald; Hystad, Sigurd William; Rykken, Sidsel; Kjosås, Ane; Søfteland, Eirik; Kvale, Gerd (Journal article; Peer reviewed, 2022)
      Background: Pulmonary rehabilitation has been demonstrated to be a highly effective treatment for people with chronic obstructive pulmonary disease (COPD). However, its availability is scarce worldwide, and new and ...

    • A Novel Evolutionary Solution Approach for Many-objective Reliability-Redundancy Allocation Problem Based on Objective Prioritization and Constraint Optimization 

      Nath, Rahul (Journal article; Peer reviewed, 2024)
      The reliability redundancy allocation problem (RRAP) has been mostly solved either as a single or as a multi-objective optimization problem. However, this problem also has numerous important constraints which play prominent ...

    • Novel hybridization- and tag-based error-corrected method for sensitive ctDNA mutation detection using ion semiconductor sequencing 

      Tjensvoll, Kjersti; Lapin, Morten; Gilje, Bjørnar; Garresori, Herish; Oltedal, Satu; Forthun, Rakel Brendsdal; Molven, Anders; Rozenholc, Yves; Nordgård, Oddmund (Journal article; Peer reviewed, 2022)
      Circulating tumor DNA (ctDNA) analysis has emerged as a clinically useful tool for cancer diagnostics and treatment monitoring. However, ctDNA detection is complicated by low DNA concentrations and technical challenges. ...

    • Novel inflammatory biomarkers in thyroid eye disease 

      Ueland, Hans Olav; Ueland, Grethe Åstrøm; Løvås, Kristian; Breivik, Lars Ertesvåg; Thrane, Alexander Stanley; Stokland, Ann-Elin Meling; Rødahl, Eyvind; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2022)
      Purpose: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves' disease (GD). Methods: Patients with GD ...

    • Novel Insights into the Pathogenesis of Human Post-Primary Tuberculosis from Archival Material of the Pre-Antibiotic Era, 1931–1947 

      Riaz, Syeda Mariam; Hanevik, Kurt; Helgeland, Lars; Sviland, Lisbet; Hunter, Robert L.; Mustafa, Tehmina (Journal article; Peer reviewed, 2023)
      Objectives: Primary and post-primary tuberculosis (TB) are distinct entities. The aim of this study was to study the histopathology of primary and post-primary TB by using the unique human autopsy material from the ...

    • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits 

      Vogelezang, Suzanne; Bradfield, Jonathan P.; Ahluwalia, Tarunveer S.; Curtin, John A.; Lakka, Timo A.; Grarup, Niels; Scholz, Markus; van der Most, Peter J.; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O.; Vilor-Tejedor, Natalia; Cousminer, Diana L.; Standl, Marie; Wang, Carol A.; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; Pitkänen, Niina; Chesi, Alessandra; Bacelis, Jonas; Yengo, Loic; Torrent, Maties; Ntalla, Ioanna; Helgeland, Øyvind; Selzam, Saskia; Vonk, Judith M.; Zafarmand, Mohammed H.; Heude, Barbara; Farooqi, Ismaa Sadaf; Alyass, Akram; Beaumont, Robin N.; Have, Christian T.; Rzehak, Peter; Bilbao, Jose Ramon; Schnurr, Theresia M.; Barroso, Inês; Bønnelykke, Klaus; Beilin, Lawrence J.; Carstensen, Lisbeth; Charles, Marie-Aline; Chawes, Bo; Clément, Karine; Closa-Monasterolo, Ricardo; Custovic, Adnan; Eriksson, Johan G.; Vaudel, Marc; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2020)
      The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...

    • The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer 

      Poduval, Deepak; Sichmanovà, Zuzana; Straume, Anne Hege; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2020)
      miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs is often deregulated in human cancers. We analyzed small RNA ...

    • A novel moderately thermophilic facultative methylotroph within the class Alphaproteobacteria 

      Islam, Tajul; Hernández, Marcela; Gessesse, Amare; Colin Murrell, Murrell; Øvreås, Lise (Journal article; Peer reviewed, 2021-02-25)
      Methylotrophic bacteria (non-methanotrophic methanol oxidizers) consuming reduced carbon compounds containing no carbon–carbon bonds as their sole carbon and energy source have been found in a great variety of environments. ...

    • A Novel Moderately Thermophilic Type Ib Methanotroph Isolated from an Alkaline Thermal Spring in the Ethiopian Rift Valley 

      Islam, Tajul; Gessesse, Amare; Garcia-Moyano, Antonio; Murrell, J. Colin; Øvreås, Lise (Journal article; Peer reviewed, 2020-02-13)
      Aerobic moderately thermophilic and thermophilic methane-oxidizing bacteria make a substantial contribution in the control of global warming through biological reduction of methane emissions and have a unique capability ...

    • A novel MRI index for paraspinal muscle fatty infiltration: reliability and relation to pain and disability in lumbar spinal stenosis: results from a multicentre study 

      Aaen, Jørn Ståle; Storheim, Kjersti; Negård, Anne; Myklebust, Tor Åge; Grotle, Margreth; Hellum, Christian; Espeland, Ansgar; Anvar, Masoud D; Indrekvam, Kari; Weber, Clemens; Brox, Jens Ivar; Brisby, Helena; Hermansen, Erland; Banitalebi, Hasan (Journal article; Peer reviewed, 2022)
      Background Fatty infiltration of the paraspinal muscles may play a role in pain and disability in lumbar spinal stenosis. We assessed the reliability and association with clinical symptoms of a method for assessing fatty ...

    • Novel neonatal simulator provides high-fidelity ventilation training comparable to real-life newborn ventilation 

      Haynes, Joanna; Bjorland, Peder Aleksander; Gomo, Øystein; Ushakova, Anastasia; Rettedal, Siren; Perlman, Jeffrey M.; Ersdal, Hege Langli (Journal article; Peer reviewed, 2021)
      Face mask ventilation of apnoeic neonates is an essential skill. However, many non-paediatric healthcare personnel (HCP) in high-resource childbirth facilities receive little hands-on real-life practice. Simulation training ...

    • Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project 

      Sigurdardóttir, Fjóla Dögg; Øverby, Tonje Caroline; Nikkonen, Sami; Karhu, Tuomas; Dammen, Toril; Nordhus, Inger Hilde; Thorshov, Thea Christine; Einvik, Gunnar; Kainulainen, Samu; Leppänen, Timo; Arnardottir, Erna Sif; Töyräs, Juha; Omland, Torbjørn; Hrubos-Strøm, Harald (Journal article; Peer reviewed, 2022)
      Novel diagnostic markers for obstructive sleep apnea beyond the apnea–hypopnea index (AHI) have been introduced. There are no studies on their association with markers of subclinical myocardial injury. We assessed the ...

    • A novel patient-reported outcome monitoring with clinical feedback system in bariatric surgery care: study protocol, design and plan for evaluation 

      Hegland, Pål Andre; Aasprang, Anny; Kolotkin, Ronette Loganzo; Moltu, Christian; Tell, Grethe S.; Andersen, John Roger (Journal article; Peer reviewed, 2020)
      Background: Consultations before and after bariatric surgery should include structured assessments of patients’ health-related quality of life (HRQOL) and mental health. One way to conduct this assessment is to implement ...