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dc.contributor.authorPålhaugen, Lene
dc.contributor.authorSudre, Carole H
dc.contributor.authorTeceläo, Sandra Raquel Ramos
dc.contributor.authorNakling, Arne
dc.contributor.authorAlmdahl, Ina Selseth
dc.contributor.authorKalheim, Lisa Flem
dc.contributor.authorCardoso, M Jorge
dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorRongve, Arvid
dc.contributor.authorAarsland, Dag
dc.contributor.authorBjørnerud, Atle
dc.contributor.authorSelnes, Per
dc.contributor.authorFladby, Tormod
dc.PublishedJournal of Cerebral Blood Flow and Metabolism. 2020, 1-13.
dc.description.abstractWhite matter hyperintensities (WMHs) are associated with vascular risk and Alzheimer’s disease. In this study, we examined relations between WMH load and distribution, amyloid pathology and vascular risk in 339 controls and cases with either subjective (SCD) or mild cognitive impairment (MCI). Regional deep (DWMH) and periventricular (PWMH) WMH loads were determined using an automated algorithm. We stratified on Aβ1-42 pathology (Aβ+/−) and analyzed group differences, as well as associations with Framingham Risk Score for cardiovascular disease (FRS-CVD) and age. Occipital PWMH (p = 0.001) and occipital DWMH (p = 0.003) loads were increased in SCD-Aβ+ compared with Aβ− controls. In MCI-Aβ+ compared with Aβ− controls, there were differences in global WMH (p = 0.003), as well as occipital DWMH (p = 0.001) and temporal DWMH (p = 0.002) loads. FRS-CVD was associated with frontal PWMHs (p = 0.003) and frontal DWMHs (p = 0.005), after adjusting for age. There were associations between global and all regional WMH loads and age. In summary, posterior WMH loads were increased in SCD-Aβ+ and MCI-Aβ+ cases, whereas frontal WMHs were associated with vascular risk. The differences in WMH topography support the use of regional WMH load as an early-stage marker of etiology.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBrain amyloid and vascular risk are related to distinct white matter hyperintensity patternsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.source.journalJournal of Cerebral Blood Flow and Metabolismen_US
dc.relation.projectNorges forskningsråd: 269774en_US
dc.identifier.citationJournal of Cerebral Blood Flow and Metabolism. 2020, 41(5):1162-1174en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal