Vis enkel innførsel

dc.contributor.authorPapp, Bela
dc.contributor.authorLaunay, Sophie
dc.contributor.authorGelebart, Pascal
dc.contributor.authorArbabian, Atousa
dc.contributor.authorEnyedi, Agnes
dc.contributor.authorBrouland, Jean-Philippe
dc.contributor.authorCarosella, Edgardo D.
dc.contributor.authorAdle-Biassette, Homa
dc.date.accessioned2021-05-10T10:03:18Z
dc.date.available2021-05-10T10:03:18Z
dc.date.created2020-08-17T14:16:12Z
dc.date.issued2020
dc.PublishedInternational Journal of Molecular Sciences. 2020, 21:3351 (9), 1-25.
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/11250/2754593
dc.description.abstractEndoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in the interaction of the ER with other organelles. Calcium is accumulated in the ER by sarco/endoplasmic reticulum calcium ATPases (SERCA enzymes) that generate by active, ATP-dependent transport, a several thousand-fold calcium ion concentration gradient between the cytosol (low nanomolar) and the ER lumen (high micromolar). SERCA enzymes are coded by three genes that by alternative splicing give rise to several isoforms, which can display isoform-specific calcium transport characteristics. SERCA expression levels and isoenzyme composition vary according to cell type, and this constitutes a mechanism whereby ER calcium homeostasis is adapted to the signaling and metabolic needs of the cell, depending on its phenotype, its state of activation and differentiation. As reviewed here, in several normal epithelial cell types including bronchial, mammary, gastric, colonic and choroid plexus epithelium, as well as in mature cells of hematopoietic origin such as pumps are simultaneously expressed, whereas in corresponding tumors and leukemias SERCA3 expression is selectively down-regulated. SERCA3 expression is restored during the pharmacologically induced differentiation of various cancer and leukemia cell types. SERCA3 is a useful marker for the study of cell differentiation, and the loss of SERCA3 expression constitutes a previously unrecognized example of the remodeling of calcium homeostasis in tumors.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleEndoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiationen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 by the authorsen_US
dc.source.articlenumber3351en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/ijms21093351
dc.identifier.cristin1823646
dc.source.journalInternational Journal of Molecular Sciencesen_US
dc.source.4021:3351
dc.source.149
dc.identifier.citationInternational Journal of Molecular Sciences. 2020, 21 (9), 3351.en_US
dc.source.volume21en_US
dc.source.issue9en_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal