Vis enkel innførsel

dc.contributor.authorDhillon, Amandeep Kaur
dc.contributor.authorRupp, Christian
dc.contributor.authorBergquist, Annika
dc.contributor.authorVoitl, Robert
dc.contributor.authorFolseraas, Trine
dc.contributor.authorTrøseid, Marius
dc.contributor.authorMidttun, Øivind
dc.contributor.authorUeland, Per Magne
dc.contributor.authorKarlsen, Tom Hemming
dc.contributor.authorVesterhus, Mette Nåmdal
dc.contributor.authorKummen, Martin
dc.contributor.authorHov, Johannes Espolin Roksund
dc.description.abstractBackground and aims Biomarkers of inflammation may be of clinical utility in primary sclerosing cholangitis (PSC). We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine–tryptophanratio (KT-ratio) in PSC. Methods Circulating neopterin, tryptophan and kynurenine were measured with LC-MS/MS in multiple cross-sectional cohorts comprising in total of 524 PSC patients and 100 healthy controls from Norway, Germany and Sweden. Results Neopterin and KT-ratio were significantly increased in PSC patients compared with controls in both a discovery and a validation cohort from Norway. Furthermore, high neopterin and KT-ratio levels were associated with a shorter transplantation-free survival in the PSC patients in the Norwegian discovery cohort and the German validation cohort. However, in the validation PSC cohort from Sweden, no relationship between neopterin and KT-ratio and liver transplantation-free survival was observed. The correlations between neopterin and KT-ratio were moderate to strong and similar in all cohorts (rho 0.50–0.67). Neopterin and KT-ratio also correlated with C-reactive protein (rho 0.17-0.63) and revised Mayo risk score (rho 0.23–0.42) in all cohorts. Conclusions Neopterin and KT-ratio were elevated in PSC and associated with liver transplantation-free survival in two independent PSC cohorts, highlighting a possible role of interferon gamma-driven inflammation in the pathogenesis. However, the lack of association with survival in one of the cohorts reduces the potential clinical value of neopterin and KT-ratioas biomarkers and highlights the need to validate new biomarkers in PSC in multiple cohorts.en_US
dc.publisherTaylor and Francisen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleAssociations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s).en_US
dc.source.journalScandinavian Journal of Gastroenterologyen_US
dc.identifier.citationScandinavian Journal of Gastroenterology. 2021, 56 (4), 443-452.en_US

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal