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Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors

dc.contributor.authorOudin, Anaïs
dc.contributor.authorBaus, Virginie
dc.contributor.authorBarthelemy, Vanessa
dc.contributor.authorFabian, Carina
dc.contributor.authorKlein, Eliane
dc.contributor.authorDieterle, Monika
dc.contributor.authorWantz, May
dc.contributor.authorHau, Ann-Christin
dc.contributor.authorDording, Claire
dc.contributor.authorBernard, Amandine
dc.contributor.authorMichelucci, Alessandro
dc.contributor.authorYabo, Yahaya A.
dc.contributor.authorKanli, Georgia
dc.contributor.authorKeunen, Olivier
dc.contributor.authorBjerkvig, Rolf
dc.contributor.authorNiclou, Simone Pierrette
dc.contributor.authorGolebiewska, Anna
dc.date.accessioned2022-04-12T08:29:12Z
dc.date.available2022-04-12T08:29:12Z
dc.date.created2022-01-24T09:03:07Z
dc.date.issued2021
dc.identifier.issn2666-1667
dc.identifier.urihttps://hdl.handle.net/11250/2991017
dc.description.abstractTumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valuable pre-clinical tools in cancer research. In this protocol, we describe efficient derivation of organoids and PDOX models from glioma patient tumors. We provide detailed steps for organoid culture, intracranial implantation, and detection of tumors in the brain. We further present technical adjustments for standardized functional assays and drug testing.en_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleProtocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumorsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.articlenumber100534en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1016/j.xpro.2021.100534
dc.identifier.cristin1988221
dc.source.journalSTAR Protocolsen_US
dc.identifier.citationSTAR Protocols. 2021, 2 (2), 100534.en_US
dc.source.volume2en_US
dc.source.issue2en_US


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