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dc.contributor.authorDempsey, Paddy C.
dc.contributor.authorAadland, Eivind
dc.contributor.authorStrain, Tessa
dc.contributor.authorKvalheim, Olav Martin
dc.contributor.authorWestgate, Kate
dc.contributor.authorLindsay, Tim
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorBrage, Søren Karl
dc.contributor.authorWijndaele, Katrien
dc.date.accessioned2022-09-27T11:06:36Z
dc.date.available2022-09-27T11:06:36Z
dc.date.created2022-05-18T14:32:42Z
dc.date.issued2022
dc.identifier.issn0091-7435
dc.identifier.urihttps://hdl.handle.net/11250/3021734
dc.description.abstractAccelerometers provide detailed data about physical activity (PA) across the full intensity spectrum. However, when examining associations with health, results are often aggregated to only a few summary measures [e.g. time spent “sedentary” or “moderate-to-vigorous” intensity PA]. Using multivariate pattern analysis, which can handle collinear exposure variables, we examined associations between the full PA intensity spectrum and cardiometabolic risk (CMR) in a population-based sample of middle-aged to older adults. Participants (n = 3660; mean ± SD age = 69 ± 8y and BMI = 26.7 ± 4.2 kg/m2; 55% female) from the EPIC-Norfolk study (UK) with valid accelerometry (ActiGraph-GT1M) data were included. We used multivariate pattern analysis with partial least squares regression to examine cross-sectional multivariate associations (r) across the full PA intensity spectrum [minutes/day at 0–5000 counts-per-minute (cpm); 5 s epoch] with a continuous CMR score (reflecting waist, blood pressure, lipid, and glucose metabolism). Models were sex-stratified and adjusted for potential confounders. There was a positive (detrimental) association between PA and CMR at 0-12 cpm (maximally-adjusted r = 0.08 (95%CI 0.06–0.10). PA was negatively (favourably) associated with CMR at all intensities above 13 cpm ranging between r = −0.09 (0.07–0.12) at 800-999 cpm and r = −0.14 (0.11–0.16) at 75–99 and 4000-4999 cpm. The strongest favourable associations were from 50 to 800 cpm (r = 0.10–0.12) in men, but from ≥2500 cpm (r = 0.18–0.20) in women; with higher proportions of model explained variance for women (R2 = 7.4% vs. 2.3%). Most of the PA intensity spectrum was beneficially associated with CMR in middle-aged to older adults, even at intensities lower than what has traditionally been considered “sedentary” or “light-intensity” activity. This supports encouragement of PA at almost any intensity in this age-group.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titlePhysical activity intensity profiles associated with cardiometabolic risk in middle-aged to older men and womenen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.articlenumber106977en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1016/j.ypmed.2022.106977
dc.identifier.cristin2025301
dc.source.journalPreventive Medicineen_US
dc.identifier.citationPreventive Medicine. 2022, 156, 106977.en_US
dc.source.volume156en_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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