Imidazole Backbone Functionalization with Olefin Cross-Metathesis
Journal article, Peer reviewed
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Date
2022Metadata
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- Department of Chemistry [442]
- Registrations from Cristin [10237]
Original version
European Journal of Organic Chemistry. 2022, 2022 (22), e202200437. 10.1002/ejoc.202200437Abstract
A selective and high-rate Ru-catalyzed cross-metathesis reaction of alkenes with vinylimidazole is disclosed. Cross-metathesis is known to operate less efficiently on N-heterocycles, but through optimization by means of statistical experimental design and multiple regression, optimal reaction conditions were identified that allowed for consistent high-yields without the need of overly complicated set-ups or additives. The method was tested on a series of terminal alkene reagents with a variety of different functional groups and it provides the corresponding target molecules in good to high yields.