dc.contributor.author | Busse-Wicher, Marta | en_US |
dc.contributor.author | Wicher, Krzysztof B. | en_US |
dc.contributor.author | Kusche-Gullberg, Marion | en_US |
dc.date.accessioned | 2015-10-20T12:32:32Z | |
dc.date.available | 2015-10-20T12:32:32Z | |
dc.date.issued | 2014-04 | |
dc.identifier.issn | 0945-053X | |
dc.identifier.uri | https://hdl.handle.net/1956/10590 | |
dc.description.abstract | Heparan sulfates are complex sulfated molecules found in abundance at cell surfaces and in the extracellular matrix. They bind to and influence the activity of a variety of molecules like growth factors, proteases and morphogens and are thus involved in various cell–cell and cell–matrix interactions. The mammalian EXT proteins have glycosyltransferase activities relevant for HS chain polymerization, however their exact role in this process is still confusing. In this review, we summarize current knowledge about the biochemical activities and some proposed functions of the members of the EXT protein family and their roles in human disease. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Elsevier | eng |
dc.rights | Attribution CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | eng |
dc.subject | EXT1 | eng |
dc.subject | EXT2 | eng |
dc.subject | EXTL | eng |
dc.subject | Heparan sulfate | eng |
dc.subject | Glycosyltransferase activities | eng |
dc.title | The extostosin family: Proteins with many functions | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2013 The Authors | |
dc.identifier.doi | https://doi.org/10.1016/j.matbio.2013.10.001 | |
dc.identifier.cristin | 1101342 | |
dc.source.journal | Matrix Biology | |
dc.source.40 | 35 | |
dc.source.pagenumber | 25-33 | |