dc.contributor.author | Davies, Gail | en_US |
dc.contributor.author | Armstrong, N | en_US |
dc.contributor.author | Bis, JC | en_US |
dc.contributor.author | Bressler, J | en_US |
dc.contributor.author | Chouraki, V | en_US |
dc.contributor.author | Giddaluru, Sudheer | en_US |
dc.contributor.author | Hofer, E | en_US |
dc.contributor.author | Ibrahim-Verbaas, CA | en_US |
dc.contributor.author | Kirin, M | en_US |
dc.contributor.author | Lahti, J | en_US |
dc.contributor.author | Van Der Lee, SJ | en_US |
dc.contributor.author | Le Hellard, Stephanie | en_US |
dc.contributor.author | Liu, T | en_US |
dc.contributor.author | Marioni, RE | en_US |
dc.contributor.author | Oldmeadow, C | en_US |
dc.contributor.author | Postmus, I | en_US |
dc.contributor.author | Smith, AV | en_US |
dc.contributor.author | Smith, JA | en_US |
dc.contributor.author | Thalamuthu, A | en_US |
dc.contributor.author | Thomson, R | en_US |
dc.contributor.author | Vitart, V | en_US |
dc.contributor.author | Wang, J | en_US |
dc.contributor.author | Yu, L | en_US |
dc.contributor.author | Zgaga, L | en_US |
dc.contributor.author | Zhao, W | en_US |
dc.contributor.author | Boxall, R | en_US |
dc.contributor.author | Harris, SE | en_US |
dc.contributor.author | Hill, WD | en_US |
dc.contributor.author | Liewald, DC | en_US |
dc.contributor.author | Luciano, M | en_US |
dc.contributor.author | Adams, H | en_US |
dc.contributor.author | Ames, D | en_US |
dc.contributor.author | Amin, N | en_US |
dc.contributor.author | Amouyel, P | en_US |
dc.contributor.author | Assareh, AA | en_US |
dc.contributor.author | Au, R | en_US |
dc.contributor.author | Becker, JT | en_US |
dc.contributor.author | Beiser, A | en_US |
dc.contributor.author | Berr, C | en_US |
dc.contributor.author | Bertram, L | en_US |
dc.contributor.author | Boerwinkle, E | en_US |
dc.contributor.author | Buckley, BM | en_US |
dc.contributor.author | Campbell, H | en_US |
dc.contributor.author | Corley, J | en_US |
dc.contributor.author | De Jager, PL | en_US |
dc.contributor.author | Dufouil, C | en_US |
dc.contributor.author | Eriksson, JG | en_US |
dc.contributor.author | Espeseth, Thomas | en_US |
dc.contributor.author | Faul, JD | en_US |
dc.contributor.author | Ford, I | en_US |
dc.contributor.author | Scotland, Generation | en_US |
dc.contributor.author | Gottesman, RF | en_US |
dc.contributor.author | Griswold, ME | en_US |
dc.contributor.author | Gudnason, V | en_US |
dc.contributor.author | Harris, TB | en_US |
dc.contributor.author | Heiss, G | en_US |
dc.contributor.author | Hofman, A | en_US |
dc.contributor.author | Holliday, EG | en_US |
dc.contributor.author | Huffman, J | en_US |
dc.contributor.author | Kardia, SLR | en_US |
dc.contributor.author | Kochan, N | en_US |
dc.contributor.author | Knopman, DS | en_US |
dc.contributor.author | Kwok, JB | en_US |
dc.contributor.author | Lambert, JC | en_US |
dc.contributor.author | Lee, T | en_US |
dc.contributor.author | Li, G | en_US |
dc.contributor.author | Li, SC | en_US |
dc.contributor.author | Loitfelder, M | en_US |
dc.contributor.author | Lopez, OL | en_US |
dc.contributor.author | Lundervold, Astri | en_US |
dc.contributor.author | Lundqvist, A | en_US |
dc.contributor.author | Mather, KA | en_US |
dc.contributor.author | Mirza, SS | en_US |
dc.contributor.author | Nyberg, L | en_US |
dc.contributor.author | Oostra, BA | en_US |
dc.contributor.author | Palotie, A | en_US |
dc.contributor.author | Papenberg, G | en_US |
dc.contributor.author | Pattie, A | en_US |
dc.contributor.author | Petrovic, K | en_US |
dc.contributor.author | Polasek, O | en_US |
dc.contributor.author | Psaty, BM | en_US |
dc.contributor.author | Redmond, P | en_US |
dc.contributor.author | Reppermund, S | en_US |
dc.contributor.author | Rotter, JI | en_US |
dc.contributor.author | Schmidt, H | en_US |
dc.contributor.author | Schuur, M | en_US |
dc.contributor.author | Schofield, PW | en_US |
dc.contributor.author | Scott, RJ | en_US |
dc.contributor.author | Steen, Vidar Martin | en_US |
dc.contributor.author | Stott, DJ | en_US |
dc.contributor.author | Van Swieten, JC | en_US |
dc.contributor.author | Taylor, KD | en_US |
dc.contributor.author | Trollor, J | en_US |
dc.contributor.author | Trompet, S | en_US |
dc.contributor.author | Uitterlinden, AG | en_US |
dc.contributor.author | Weinstein, G | en_US |
dc.contributor.author | Widen, E | en_US |
dc.contributor.author | Windham, BG | en_US |
dc.contributor.author | Jukema, JW | en_US |
dc.contributor.author | Wright, AF | en_US |
dc.contributor.author | Wright, MJ | en_US |
dc.contributor.author | Yang, Q | en_US |
dc.contributor.author | Amieva, H | en_US |
dc.contributor.author | Attia, JR | en_US |
dc.contributor.author | Bennett, DA | en_US |
dc.contributor.author | Brodaty, H | en_US |
dc.contributor.author | De Craen, AJM | en_US |
dc.contributor.author | Hayward, C | en_US |
dc.contributor.author | Ikram, MA | en_US |
dc.contributor.author | Lindenberger, U | en_US |
dc.contributor.author | Nilsson, LG | en_US |
dc.contributor.author | Porteous, DJ | en_US |
dc.contributor.author | Räikkönen, K | en_US |
dc.contributor.author | Rudan, I | en_US |
dc.contributor.author | Sachdev, PS | en_US |
dc.contributor.author | Schmidt, R | en_US |
dc.contributor.author | Schofield, PR | en_US |
dc.contributor.author | Srikanth, V | en_US |
dc.contributor.author | Starr, JM | en_US |
dc.contributor.author | Turner, ST | en_US |
dc.contributor.author | Weir, DR | en_US |
dc.contributor.author | Wilson, JF | en_US |
dc.contributor.author | Van Duijn, C | en_US |
dc.contributor.author | Launer, L | en_US |
dc.contributor.author | Fitzpatrick, AL | en_US |
dc.contributor.author | Seshadri, S | en_US |
dc.contributor.author | Mosley, TH | en_US |
dc.contributor.author | Deary, IJ | en_US |
dc.contributor.author | Reinvang, Ivar | en_US |
dc.date.accessioned | 2016-03-02T14:10:24Z | |
dc.date.available | 2016-03-02T14:10:24Z | |
dc.date.issued | 2015 | |
dc.Published | Molecular Psychiatry 2015, 20(2):183-192 | eng |
dc.identifier.issn | 1476-5578 | |
dc.identifier.uri | https://hdl.handle.net/1956/11419 | |
dc.description.abstract | General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10−9, MIR2113; rs17522122, P=2.55 × 10−8, AKAP6; rs10119, P=5.67 × 10−9, APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10−6). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10−17). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer’s disease: TOMM40, APOE, ABCG1 and MEF2C. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Nature Publishing Group | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-30T17:10:59Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 The Authors | |
dc.identifier.doi | https://doi.org/10.1038/mp.2014.188 | |
dc.identifier.cristin | 1275878 | |
dc.subject.nsi | VDP::Samfunnsvitenskap: 200::Psykologi: 260::Kognitiv psykologi: 267 | |
dc.subject.nsi | VDP::Social sciences: 200::Psychology: 260::Cognitive psychology: 267 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714 | |
dc.subject.nsi | VDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714 | |