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dc.contributor.authorPrandina, Anthony
dc.contributor.authorHerfindal, Lars
dc.contributor.authorRadix, S
dc.contributor.authorRongved, Pål
dc.contributor.authorDoskeland, Stein Ove
dc.contributor.authorLe Borgne, Marc
dc.contributor.authorPerret, F
dc.PublishedPrandina A, Herfindal L, Radix, Rongved PR, Doskeland SO, Le Borgne M, Perret. Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of enzyme inhibition and medicinal chemistry. 2018;33(1):370-375eng
dc.description.abstractPhenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in aqueous solutions. Its water solubility has led to the development of new formulations using diverse amphiphilic a-cyclodextrins (CDs). With the per-[6-desoxy-6-(3-perfluorohexylpropanethio)-2,3-di-O-methyl]- a-CD, we succeeded to get iodinin-loaded nanoformulations with good parameters such as a size of 97.9 nm, 62% encapsulation efficiency and efficient control release. The study presents an interesting alternative to optimizing the water solubility of iodinin by chemical modifications of iodinin.eng
dc.publisherTaylor & Franciseng
dc.rightsAttribution CC BYeng
dc.titleEnhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticleseng
dc.typeJournal articleeng
dc.typePeer reviewed
dc.rights.holderCopyright 2018 The Authorseng
dc.source.journalJournal of enzyme inhibition and medicinal chemistry

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