dc.contributor.author | Prandina, Anthony | |
dc.contributor.author | Herfindal, Lars | |
dc.contributor.author | Radix, S | |
dc.contributor.author | Rongved, Pål | |
dc.contributor.author | Doskeland, Stein Ove | |
dc.contributor.author | Le Borgne, Marc | |
dc.contributor.author | Perret, F | |
dc.date.accessioned | 2020-10-29T09:22:50Z | |
dc.date.available | 2020-10-29T09:22:50Z | |
dc.date.issued | 2018 | |
dc.Published | Prandina A, Herfindal L, Radix, Rongved PR, Doskeland SO, Le Borgne M, Perret. Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of enzyme inhibition and medicinal chemistry. 2018;33(1):370-375 | eng |
dc.identifier.issn | 1475-6366 | |
dc.identifier.issn | 1475-6374 | |
dc.identifier.uri | https://hdl.handle.net/1956/24436 | |
dc.description.abstract | Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to
enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in
aqueous solutions. Its water solubility has led to the development of new formulations using diverse
amphiphilic a-cyclodextrins (CDs). With the per-[6-desoxy-6-(3-perfluorohexylpropanethio)-2,3-di-O-methyl]-
a-CD, we succeeded to get iodinin-loaded nanoformulations with good parameters such as a size of
97.9 nm, 62% encapsulation efficiency and efficient control release. The study presents an interesting alternative
to optimizing the water solubility of iodinin by chemical modifications of iodinin. | eng |
dc.language.iso | eng | eng |
dc.publisher | Taylor & Francis | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles | eng |
dc.type | Journal article | eng |
dc.type | Peer reviewed | |
dc.date.updated | 2018-03-27T08:41:08Z | |
dc.description.version | publishedVersion | |
dc.rights.holder | Copyright 2018 The Authors | eng |
dc.identifier.doi | https://doi.org/10.1080/14756366.2017.1421638 | eng |
dc.identifier.cristin | 1572982 | |
dc.source.journal | Journal of enzyme inhibition and medicinal chemistry | |