Department of Clinical Science: Recent submissions

Now showing items 181-200 of 2318

    • Atrial Dysfunction in Significant Atrial Functional Mitral Regurgitation: Phenotypes and Prognostic Implications 

      Cramariuc, Dana; Alfraidi, Hassan; Nagata, Yasufumi; Levine, Robert A.; Van Kampen, Antonia; Andrews, Carl; Hung, Judy (Journal article; Peer reviewed, 2023)
      Background: Atrial functional mitral regurgitation (AFMR) is associated with increased morbidity and mortality. Left atrial (LA) size and function in AFMR are poorly characterized. We aimed to assess LA function by reservoir ...

    • Skåringsverktøy for tidlig oppdagelse av sepsis på sengepost 

      Karlsen, Elisabet Ethun; Rønsåsbjørg, Nora Almlid; Skrede, Steinar; Mosevoll, Knut Anders (Journal article; Peer reviewed, 2023)
      BAKGRUNN Sepsis er en av de vanligste årsakene til død i norske sykehus. Tilstanden er ofte oversett og behandlingen forsinket. Skåringsverktøy for å oppdage pasienter med sepsis er hyppigst undersøkt i akuttmottak, ...

    • Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma 

      Lapitz, Ainhoa; Azkargorta, Mikel; Milkiewicz, Piotr; Olaizola, Paula; Zhuravleva, Ekaterina; Grimsrud, Marit Mæhle; Schramm, Christoph; Arbelaiz, Ander; O'Rourke, Colm J.; La Casta, Adelaida; Milkiewicz, Malgorzata; Pastor, Tania; Vesterhus, Mette Nåmdal; Jimenez-Agüero, Raul; Dill, Michael T.; Lamarca, Angela; Valle, Juan W.; Macias, Rocio I.R.; Izquierdo-Sanchez, Laura; Pérez Castaño, Ylenia; Caballero-Camino, Francisco Javier; Riaño, Ioana; Krawczyk, Marcin; Ibarra, Cesar; Bustamante, Javier; Nova-Camacho, Luiz M.; Falcon-Perez, Juan M.; Elortza, Felix; Perugorria, Maria J.; Andersen, Jesper B.; Bujanda, Luis; Karlsen, Tom Hemming; Folseraas, Trine; Rodrigues, Pedro M.; Banales, Jesus M. (Journal article; Peer reviewed, 2023)
      Background & Aims Cholangiocarcinoma (CCA), heterogeneous biliary tumours with dismal prognosis, lacks accurate early diagnostic methods especially important for individuals at high-risk (i.e. those with primary sclerosing ...

    • Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment 

      Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Aleksandr (Journal article; Peer reviewed, 2023)
      The gut microbiota play a crucial role in maintaining host health and have a significant impact on human health and disease. In this study, we investigated the alpha diversity of gut microbiota in COVID-19 patients and ...

    • Obesity wars: hypothalamic sEVs a new hope 

      Mukherjee, Sayani; Diéguez, Carlos; Fernø, Johan; López, Miguel (Journal article; Peer reviewed, 2023)
      There are currently several pharmacological therapies available for the treatment of obesity, targeting both the central nervous system (CNS) and peripheral tissues. In recent years, small extracellular vesicles (sEVs) ...

    • Platelets for advanced drug delivery in cancer 

      Cacic, Daniel Limi; Hervig, Tor; Reikvam, Håkon (Journal article; Peer reviewed, 2023)
      Introduction: Cancer-related drug expenses are rising with the increasing cancer incidence and cost may represent a severe challenge for drug access for patients with cancer. Consequently, strategies for increasing therapeutic ...

    • Integrated analysis of robust sex-biased gene signatures in human brain 

      Wapeesittipan, Pattama; Joshi, Anagha (Journal article; Peer reviewed, 2023)
      Background: Sexual dimorphism is highly prominent in mammals with many physiological and behavioral differences between male and female form of the species. Accordingly, the fundamental social and cultural stratification ...

    • The Effect of Biological Treatment on Fatigue in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis 

      Skjellerudsveen, Berit Mære; Skoie, Inger Marie; Dalen, Ingvild; Grimstad, Tore Bjørn; Omdal, Roald (Journal article; Peer reviewed, 2023)
      Background: Fatigue is a frequent complaint in patients with inflammatory bowel disease. Biological drugs have demonstrated beneficial effects on some extraintestinal manifestations, but the effect on fatigue is not ...

    • Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider 

      Burska, Agata; Rodríguez-Carrio, Javier; Biesen, Robert; Dik, Willem A.; Eloranta, Maija-Leena; Cavalli, Giulio; Visser, Marianne; Boumpas, Dimitrios T.; Bertsias, George; Wahren Herlenius, Marie Elisabeth; Rehwinkel, Jan; Frémond, Marie-Louise; Crow, Mary K.; Ronnblom, Lars; Conaghan, P.G.; Versnel, Marjan; Vital, Ed (Journal article; Peer reviewed, 2023)
      Objectives: To systematically review the literature for assay methods that aim to evaluate type I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods: Three databases were searched for ...

    • Fluoroquinolone resistance among fecal extended spectrum βeta lactamases positive Enterobacterales isolates from children in Dar es Salaam, Tanzania 

      Kibwana, Upendo O.; Manyahi, Joel; Sandnes, Helene Heitmann; Blomberg, Bjørn; Mshana, Stephen E.; Langeland, Nina; Roberts, Adam P.; Moyo, Sabrina John (Journal article; Peer reviewed, 2023-03-07)
      Background: Fluoroquinolones have been, and continue to be, routinely used for treatment of many bacterial infections. In recent years, most parts of the world have reported an increasing trend of fluoroquinolone resistant ...

    • Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression 

      Holen, Børge; Shadrin, Alexey; Icick, Romain; Filiz, Tahir Tekin; Hindley, Guy Frederick Lanyon; Rødevand, Linn; O'Connell, Kevin Sean; Hagen, Espen; Frei, Oleksandr; Bahrami, Shahram; Cheng, Weiqiu; Parker, Nadine; Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Karadag, Naz; Dale, Anders M; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Opioid use disorder (OUD) and mental disorders are often comorbid, with increased morbidity and mortality. The causes underlying this relationship are poorly understood. Although these conditions are highly heritable, their ...

    • VACCELERATE Site Network: Real-time definition of clinical study capacity in Europe 

      Salmanton-García, Jon; Wipfler, Pauline; Valle-Simón, Paula; Merakou, Christina; Kopsidas, Ioannis; Bethe, Ullrich; Steinbach, Angela; Spivak, Orly; Součková, Lenka; Mendonça, Maria Amélia; Koniordou, Markela; Hellemans, Margot; Frías-Iniesta, Jesus; Davis, Ruth Joanna; Barta, Imre; Azzini, Anna Maria; Askling, Helena H.; Argyropoulos, Christos D.; Álvarez-Barco, Elena; Akova, Murat; Bonten, Marc M.J.; Cohen-Kandli, Miriam; Cox, Rebecca Jane; Flisiak, Robert; Husa, Petr; Jancoriene, Ligita; Koscalova, Alena; Launay, Odile; Lundgren, Jens; Mallon, Patrick; Marques, Laura; Nauclér, Pontus; Ochando, Jordi; Pana, Zoi-Dorothea; Tacconelli, Evelina; Tóth, Krisztina; Trelle, Sven; van Damme, Pierre; Zaoutis, Theoklis E.; Zeitlinger, Markus; Albus, Kerstin; Stewart, Fiona A.; Hofstraat, Sanne H.I.; Bruijning-Verhagen, Patricia; Cornely, Oliver A. (Journal article; Peer reviewed, 2023)
      Background: The inconsistent European vaccine trial landscape rendered the continent of limited interest for vaccine developers. The VACCELERATE consortium created a network of capable clinical trial sites throughout Europe. ...

    • Arterial Stiffness in Overweight and Obesity: Association with Sex, Age, and Blood Pressure 

      Eikås, John Glad; Gerdts, Eva; Halland, Hilde; Midtbø, Helga Bergljot; Cramariuc, Dana; Kringeland, Ester Anne (Journal article; Peer reviewed, 2023)
      Introduction: Obesity has been associated with increased arterial stiffness. Sex-differences in arterial stiffness in obesity have been less explored. Aim: To explore sex-differences in arterial stiffness by applanation ...

    • Identification of biomarkers for glycaemic deterioration in type 2 diabetes 

      Slieker, Roderick C.; Donnelly, Louise A.; Akalestou, Elina; Lopez-Noriega, Livia; Melhem, Rana; Güneş, Ayşim; Abou Azar, Frederic; Efanov, Alexander; Georgiadou, Eleni; Muniangi-Muhitu, Hermine; Sheikh, Mahsa; Giordano, Giuseppe N.; Åkerlund, Mikael; Ahlqvist, Emma; Ali, Ashfaq; Banasik, Karina; Brunak, Søren; Barovic, Marko; Bouland, Gerard A.; Burdet, Frédéric; Canouil, Mickaël; Dragan, Iulian; Elders, Petra J. M.; Fernandez, Celine; Festa, Andreas; Fitipaldi, Hugo; Froguel, Phillippe; Gudmundsdottir, Valborg; Gudnason, Vilmundur; Gerl, Mathias J.; van der Heijden, Amber A.; Jennings, Lori L.; Hansen, Michael K.; Kim, Min; Leclerc, Isabelle; Klose, Christian; Kuznetsov, Dmitry; Mansour Aly, Dina; Mehl, Florence; Marek, Diana; Melander, Olle; Niknejad, Anne; Ottosson, Filip; Pavo, Imre; Duffin, Kevin; Syed, Samreen K.; Shaw, Janice L.; Cabrera, Over; Pullen, Timothy J.; Simons, Kai; Solimena, Michele; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter; Lyssenko, Valeriya; Legido Quigley, Cristina; Groop, Leif; Thorens, Bernard; Franks, Paul W.; Lim, Gareth E.; Estall, Jennifer; Ibberson, Mark; Beulens, Joline W. J.; ’t Hart, Leen M; Pearson, Ewan R.; Rutter, Guy A. (Journal article; Peer reviewed, 2023)
      We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic ...

    • The influence of immigrant background and parental education on overweight and obesity in 8-year-old children in Norway 

      Øvrebø, Bente; Kjøllesdal, Marte Karoline Råberg; Stea, Tonje Holte; Wills, Andrew Keith; Bere, Elling Tufte; Magnus, Per Minor; Juliusson, Pétur Benedikt; Bergh, Ingunn Holden (Journal article; Peer reviewed, 2023)
      Background Little is known about the prevalence of overweight/obesity and socio-economic position (SEP) in children with immigrant background in Scandinavia. The purpose of this study is to examine the prevalence of ...

    • Diabetes mellitus impact on fetal liver circulation, and new diagnostic options 

      Kiserud, Torvid (Journal article; Peer reviewed, 2023)
      While biometry and Doppler have proved useful in the management of fetal growth restriction, the same battery has been of less help in diabetic pregnancies. It is not surprising since the underlying pathophysiology is ...

    • Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero 

      Nilsen, Guro Ørndal; Simpson, Melanie Rae; Hanem, Liv Guro Engen; Løvvik, Tone Shetelig; Ødegård, Rønnaug Astri; Stokkeland, Live Marie T; Andersen, Marianne; Juliusson, Pétur Benedikt; Vanky, Eszter Ilona (Journal article; Peer reviewed, 2023)
      Introduction: Fetal growth may be affected by both maternal polycystic ovary syndrome (PCOS) and metformin therapy. Here, we explore the effect of intrauterine metformin exposure on birth anthropometrics of infants born ...

    • Substantial changes in inflammatory and cardiovascular biomarkers in patients with autonomous cortisol secretion 

      Ueland, Grethe Åstrøm; Methlie, Paal; Heie, Anette; Stokland, Ann-Elin Meling; Dahle, Anne Lise; Sævik, Åse Bjorvatn; Løvås, Kristian; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      Objective To map inflammatory biomarkers in patients with autonomous cortisol secretion (ACS) and overt Cushing syndrome (CS). Method Observational study including serum from prospectively included patients with ACS ...

    • Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation 

      Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin; Bossen, Lars; Engesæter, Lise Katrine; Reims, Henrik Mikael; Bjørk, Ida Torunn; Grzyb, Krzysztof; Abildgaard, Andreas; Småstuen, Milada Cvancarova; Folseraas, Trine; Trøseid, Marius; Ulvik, Arve; Ueland, Per Magne; Melum, Espen; Line, Pål Dag; Høivik, Marte Lie; Grønbæk, Henning; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2023)
      Background and aims We previously demonstrated that people with primary sclerosing cholangitis (PSC) had reduced gut microbial capacity to produce active vitamin B6 (pyridoxal 5’-phosphate [PLP]), which corresponded to ...

    • Genomic epidemiology of Streptococcus dysgalactiae subsp. equisimilis strains causing invasive disease in Norway during 2018 

      Kaci, Alba; Jonassen, Christine M; Skrede, Steinar; Sivertsen, Audun; Steinbakk, Martin; Oppegaard, Oddvar (Journal article; Peer reviewed, 2023)
      Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an emerging global pathogen, yet the epidemiology and population genetics of SDSE species have not been extensively characterized. Methods: We ...