Department of Clinical Science: Recent submissions
Now showing items 281-300 of 2318
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Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies
(Journal article; Peer reviewed, 2023)Objectives: Autoantibodies are thought to play a key role in the pathogenesis of idiopathic inflammatory myopathies (IIM). However, up to 40% of IIM patients, even those with clinical manifestations of anti-synthetase ... -
Legemiddelkunnskap i barne- og ungdomsskoler
(Master thesis, 2023-05-23)Bakgrunn: Kunnskap om rasjonell bruk av legemidler er viktig for alle, ikke minst for barn og unge. De siste årene er det dokumentert økt selvmedisinering blant barn og unge i Norge, blant annet med økt bruk av Paracet og ... -
Påvirkning av stabilisator i phytantriol-baserte kubosomer og dens potensielle anvendelse som intravenøs levering av lumefantrin
(Master thesis, 2023-06-05)Malaria er en parasittsykdom som tar livet av nesten av en halv million mennesker hvert år. Malariabyrden har gått betraktelig ned på verdensbasis, men for 84 land gjenstår det å utrydde sykdommen. Lumefantrin (LUM) i ... -
Levels of per- and polyfluoroalkyl substances (PFAS) in Norwegian children stratified by age and sex - Data from the Bergen Growth Study 2
(Journal article; Peer reviewed, 2023)Background and aim Due to the persistence, bioaccumulation and potential adverse health effects, there have been restrictions and phase out in the production of certain per- and polyfluoroalkyl substances (PFAS) since the ... -
Multifasettert analyse av stabilitet og reologiske egenskaper i forbindelse med formulering av karbamidkremer
(Master thesis, 2023-06-06)Karbamidkrem har bred klinisk anvendelse innen dermatologi for behandling av tørr hud, kløe og atopisk eksem, takket være dens fuktighetsgivende og keratolytiske egenskaper. Kremformuleringer er imidlertid termodynamisk ... -
A polygenic risk score to help discriminate primary adrenal insufficiency of different etiologies
(Journal article; Peer reviewed, 2023)Background Autoimmune Addison's disease (AAD) is the most common cause of primary adrenal insufficiency (PAI). Despite its exceptionally high heritability, tools to estimate disease susceptibility in individual patients ... -
A pharmacokinetic study of NAD replenishment therapy using Nicotinamide Riboside
(Master thesis, 2023-05-22)Parkinson`s disease (PD) is a major cause of death and disability, and currently only symptomatic treatment is available. Nicotinamide adenine dinucleotide (NAD) is a crucial molecule for maintaining life and promoting ... -
A pharmacokinetic study of Nicotinamide Mononucleotide as a potential therapy for Parkinson's Disease
(Master thesis, 2023-05-22)Parkinson’s disease (PD) is a common age-related neurodegenerative disorder, with a rapidly increasing age-dependent prevalence. Current treatment offers some symptomatic relief but has no effect on disease progression. ... -
Evaluering av et kortformat e-læringsprogram og dets effekt på apotekansattes kommunikasjon med ungdommer som vil kjøpe reseptfrie smertestillende legemidler i apotek
(Master thesis, 2023-05-22)Bakgrunn: Omtrent 1 av 5 norske ungdommer i aldersgruppen 13–18 år, bruker smertestillende legemidler minst ukentlig (1). Samtidig har Giftinformasjonen de siste årene rapportert om en økning i antall henvendelser om ... -
Learning from experience: a qualitative study of surgeons’ perspectives on reporting and dealing with serious adverse events
(Journal article; Peer reviewed, 2023)Introduction In surgery, serious adverse events have effects on the patient journey, the patient outcome and may constitute a burden to the surgeon involved. This study aims to investigate facilitators and barriers to ... -
Maternal and iatrogenic factors influencing the duration of labour
(Doctoral thesis, 2023-06-22)Bakgrunn: Forlengede fødselsforløp er den fremste grunnen til keisersnitt og operative vaginale forløsninger på verdensbasis. Imidlertid er definisjonen av normal fødselsprogresjon og varighet gjenstand for en pågående ... -
Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study
(Journal article; Peer reviewed, 2023)Objective: To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS). Design: Cohort study using a nationwide, population-based ... -
Measurement of left ventricular deformation using 3D echocardiography
(Doctoral thesis, 2023-06-05)Bakgrunn: 3D speckle tracking ekkokardiografi (STE) er en hjerteultralydmetode som gir mulighet for måling av deformasjonsparametere, som strain, rotasjon, tvist og torsjon. Den største begrensningen for 3D STE er lav tids- ... -
Physical and cognitive performance after blood donation : A clinical study to investigate donor safety in walking blood banks
(Doctoral thesis, 2023-06-13)De siste 20 årene har fullblod til pasienter i blødningssjokk blitt re-lansert som foretrukket behandling. I vandrende blodbanker blir blodet oppbevart i original forpakningen inntil behovet oppstår. Konseptet har logistiske ... -
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
(Journal article; Peer reviewed, 2023)Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ... -
Co-design of a behaviour change intervention to equip geriatricians and pharmacists to proactively deprescribe medicines that are no longer needed or are risky to continue in hospital
(Journal article; Peer reviewed, 2023)Background: Trials of hospital deprescribing interventions have demonstrated limited changes in practitioner behaviour. Our previous research characterised four barriers and one enabler to geriatricians and pharmacists ... -
GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2
(Journal article; Peer reviewed, 2023-01-12)Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy. Use of cDCs ... -
Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
(Journal article; Peer reviewed, 2023)Background: The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin resistance and type 2 diabetes, but implicated ... -
PIK3CA mutations and their impact on survival outcomes of patients with endometrial cancer: A systematic review and meta-analysis
(Journal article; Peer reviewed, 2023-03-21)Several studies have highlighted the frequent alterations of the PI3K pathway in endometrial cancer leading to increased signaling activation with potential for targeted treatment. The objective of this meta-study was to ...