Browsing Faculty of Medicine by Title
Now showing items 3250-3269 of 8845
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A flexible formula for incorporating distributive concerns into cost-effectiveness analyses: Priority weights
(Peer reviewed; Journal article, 2019-10-10)Background Cost effectiveness analyses (CEAs) are widely used to evaluate the opportunity cost of health care investments. However, few functions that take equity concerns into account are available for such CEA methods, ... -
Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease
(Journal article; Peer reviewed, 2020)Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, ... -
Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome
(Doctoral thesis, 2017-03-09)Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltrates of exocrine glands, notably the salivary and lacrimal glands combined with immune-mediated glandular destruction. ... -
Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets
(Peer reviewed; Journal article, 2014-06-21)Background: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate ... -
Flt3 receptor tyrosine kinase in AML and its modulation of the p53/Hdm2/Bcl-2 pathway
(Doctoral thesis, 2007-09-06)Acute myeloid leukemia (AML) is an aggressive disease with a poor overall survival rate. The most frequent mutations associated with AML are internal tandem duplications (ITD) in the juxtamembrane region of the receptor ... -
FLT3-ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation
(Journal article; Peer reviewed, 2021)Recurrent somatic internal tandem duplications (ITD) in the FMS-like tyrosine kinase 3 (FLT3) gene characterise approximately one third of patients with acute myeloid leukaemia (AML), and FLT3-ITD mutation status guides ... -
Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF
(Journal article; Peer reviewed, 2021)Background & Aims Primary sclerosing cholangitis (PSC) is a progressive liver disease characterised by fluctuating liver biochemistries and highly variable disease progression. The Enhanced Liver Fibrosis (ELF®) test and ... -
Fluctuations of sensorimotor processing in migraine: A controlled longitudinal study of beta event related desynchronization
(Peer reviewed; Journal article, 2019-07-09)Background: The migraine brain seems to undergo cyclic fluctuations of sensory processing. For instance, during the preictal phase, migraineurs experience symptoms and signs of altered pain perception as well as other ... -
Fluid transport from the dental pulp revisited.
(Journal article; Peer reviewed, 2020-10)In the dental pulp surrounded by rigid dentinal walls, an increase in fluid volume will be followed by a rapid increase in interstitial fluid pressure. To maintain pressure homeostasis, a fluid drainage system is required. ... -
Fluid-sensitive migration mechanisms predict association between metastasis and high interstitial fluid pressure in pancreatic cancer
(Journal article; Peer reviewed, 2022)A remarkable feature in pancreatic cancer is the propensity to metastasize early, even for small, early stage cancers. We use a computer-based pancreatic model to simulate tumor progression behavior where fluid-sensitive ... -
Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes
(Journal article; Peer reviewed, 2022)The identification and removal of all gross and microscopic tumor to render the patient disease free represents a huge challenge in ovarian cancer treatment. The presence of residual disease is an independent negative ... -
Fluoroquinolone resistance among fecal extended spectrum βeta lactamases positive Enterobacterales isolates from children in Dar es Salaam, Tanzania
(Journal article; Peer reviewed, 2023-03-07)Background: Fluoroquinolones have been, and continue to be, routinely used for treatment of many bacterial infections. In recent years, most parts of the world have reported an increasing trend of fluoroquinolone resistant ... -
An fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominance
(Peer reviewed; Journal article, 2019)Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in ... -
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis
(Journal article; Peer reviewed, 2023)Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and ... -
Folate and reproductive health. An epidemiologic study of folic acid supplement use and its relation to birth outcomes in Norwegian pregnant women
(Doctoral thesis, 2010-04-23)Background: Randomized trials and observational studies have consistently shown that maternal intake of folic acid supplements before and early in pregnancy reduces the risk of neural tube defects in infants. These reports ... -
Folate Status as a Nutritional Indicator among People with Substance Use Disorder; A Prospective Cohort Study in Norway
(Journal article; Peer reviewed, 2022)Substance use disorder (SUD) is associated with poor nutrition. Vitamin B9, or folate, is an important micronutrient for health. The aim of this prospective longitudinal cohort study was to assess serum folate levels among ... -
Folic Acid and Risk of Preterm Birth, Preeclampsia, and Fetal Growth Restriction Among Women With Epilepsy A Prospective Cohort Study
(Journal article; Peer reviewed, 2022)Background and Objectives Women with epilepsy treated with antiseizure medication (ASM) have increased risk of pregnancy complications including preterm birth, fetal growth restriction, and preeclampsia. We aimed to ... -
Folic acid in pregnancy and subsequent cancer risk in mothers and their children: An epidemiologic study in Norway, 1999–2010
(Doctoral thesis, 2019-06-24)Background: Observational studies and randomized trials have shown that maternal folic acid supplementation before and during early pregnancy decreases the risk of neural tube defects in offspring. Hence, women of fertile ... -
Folic acid supplementation and biomarkers of progression of sub-clinical coronary atherosclerosis in patients with stable angina pectoris. A WENBIT sub-study based on coronary angiography and intravascular ultrasound
(Doctoral thesis, 2014-04-09)Background: Coronary artery disease (CAD) is the leading cause of death in the world. Total plasma homocysteine (tHcy) is an independent risk factor for CAD, and while tHcy is lowered by folic acid (FA)/vitamin B12 (B12) ... -
Folic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: a prospective observational cohort study
(Peer reviewed; Journal article, 2014-11-02)Background: Health authorities in numerous countries recommend periconceptional folic acid supplementation to prevent neural tube defects. The objective of this study was to examine the association of dietary folate intake ...