Browsing Faculty of Medicine by Title

Now showing items 3969-3988 of 8851

    • How to schedule night shift work in order to reduce health and safety risks 

      Garde, Anne Helene; Begtrup, Luise; Bjorvatn, Bjørn; Bonde, Jens Peter; Hansen, Johnni; Hansen, Åse Marie; Härmä, Mikko; Jensen, Marie Aarrebo; Kecklund, Göran; Kolstad, Henrik A.; Larsen, Ann Dyreborg; Lie, Jenny-Anne Sigstad; Moreno, Claudia; Nabe-Nielsen, Kirsten; Sallinen, Mikael (Journal article; Peer reviewed, 2020)
      Objectives This discussion paper aims to provide scientifically based recommendations on night shift schedules, including consecutive shifts, shift intervals and duration of shifts, which may reduce health and safety risks. ...

    • How well did Norwegian general practice prepare to address the COVID-19 pandemic? 

      Alsnes, Ingvild Vatten; Munkvik, Morten; Flanders, Dana W; Øyane, Nicolas M.F. (Journal article, 2020)
      Objectives We aimed to describe the quality improvement measures made by Norwegian general practice (GP) during the COVID-19 pandemic, evaluate the differences in quality improvements based on region and assess the ...

    • How, not if, is the question mycologists should be asking about DNA-based typification 

      Nilsson, R. Henrik; Ryberg, Martin; Wurzbacher, Christian; Tedersoo, Leho; Anslan, Sten; Põlme, Sergei; Spirin, Viacheslav; Mikryukov, Vladimir; Svantesson, Sten; Hartmann, Martin; Lennartsdotter, Charlotte; Belford, Pauline; Khomich, Maryia; Retter, Alice; Corcoll, Natàlia; Martinez, Daniela Gómez; Jansson, Tobias; Ghobad-Nejhad, Masoomeh; Vu, Duong; Sanchez-Garcia, Marisol; Kristiansson, Erik; Abarenkov, Kessy (Journal article; Peer reviewed, 2023)
      Fungal metabarcoding of substrates such as soil, wood, and water is uncovering an unprecedented number of fungal species that do not seem to produce tangible morphological structures and that defy our best attempts at ...

    • HPV DNA testing improves CIN2+ risk stratification and detection of CIN2+ in delayed triage of ASCUS and LSIL. A population-based follow-up study from Western Norway 

      Budal, Elisabeth Berge; Haugland, Hans Kristian; Skar, Robert; Mæhle, Bjørn Ove; Bjørge, Tone; Vintermyr, Olav Karsten (Peer reviewed; Journal article, 2014-02)
      In Norway, Pap smears with atypical squamous cells of uncertain significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) are triaged after 6 months. The aim of the study was to evaluate effects of ...

    • HPV self-sampling among long-term non-attenders to cervical cancer screening in Norway: a pragmatic randomised controlled trial 

      Aasbø, Gunvor; Trope, Ameli; Nygård, Mari; Christiansen, Irene Kraus; Baasland, Ingrid; Iversen, Grete Alræk; Munk, Ane Cecilie Dæhli; Christiansen, Marit Halonen; Presthus, Gro Kummeneje; Undem, Karina; Bjørge, Tone; Castle, Philip E.; Hansen, Bo Lars Thorvald Terning (Journal article; Peer reviewed, 2022)
      Background Cervical cancer screening participation is suboptimal in most settings. We assessed whether human papillomavirus (HPV) self-sampling may increase screening participation among long-term non-attenders in Norway. ...

    • HSF1 Can Prevent Inflammation following Heat Shock by Inhibiting the Excessive Activation of the ATF3 and JUN&FOS Genes 

      Janus, Patryk; Kuś, Paweł; Vydra, Natalia; Toma-Jonik, Agnieszka; Stokowy, Tomasz; Mrowiec, Katarzyna; Wojtaś, Bartosz; Gielniewski, Bartłomiej; Widłak, Wiesława (Journal article; Peer reviewed, 2022)
      Heat Shock Factor 1 (HSF1), a transcription factor frequently overexpressed in cancer, is activated by proteotoxic agents and participates in the regulation of cellular stress response. To investigate how HSF1 level affects ...

    • HSP27 Expression as a Novel Predictive Biomarker for Bevacizumab: is it Cost Effective? 

      Seo, Mikyung Kelly; Straume, Oddbjørn; Akslen, Lars A.; Cairns, John Alexander (Journal article; Peer reviewed, 2020)
      Background: Despite the extensive use of bevacizumab in a range of oncology indications, the US FDA revoked its approval for breast cancers, and multiple negative trials in several solid malignancies have been reported, ...

    • Huge variation in obtaining ethical permission for a non-interventional observational study in Europe 

      de Lange, Dylan W.; Guidet, Bertrand R.; Andersen, Finn Husøy; Artigas, Antonio; Bertolini, Guido; Moreno, Rui; Christensen, Steffen; Cecconi, Maurizio; Agvald-Öhman, Christina; Gradišek, Primož; Jung, Christian; Marsh, Brian J.; Oeyen, Sandra; Bollen Pinto, Bernardo; Szczeklik, Wojciech; Watson, Ximena; Zafeiridis, Tilemachos; Flaatten, Hans (Peer reviewed; Journal article, 2019-06-03)
      Background Ethical approval (EA) must be obtained before medical research can start. We describe the differences in EA for an pseudonymous, non-interventional, observational European study. Methods Sixteen European national ...

    • Human blood serum proteome changes after 6 hours of sleep deprivation at night 

      Bjørkum, Alvhild Alette; Duran, Ana Carasco; Berven, Frode Steingrimsen; Roy, Dola Sinha; Rosendahl, Karen; Birkeland, Even; Stuhr, Linda Elin Birkhaug (Journal article; Peer reviewed, 2021)
      Background The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories ...

    • A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer 

      Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen; Hoem, Dag; Schjøtt, Jan; Gjertsen, Bjørn Tore; Biermann, Martin; Molven, Anders; Sorbye, Halfdan; McCormack, Emmet; Postema, Michiel; Gilja, Odd Helge (Peer reviewed; Journal article, 2016-12)
      Background: The primary aim of our study was to evaluate the safety and potential toxicity of gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer patients. The secondary aim was to ...

    • Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins 

      Hill, Wayne David; Davies, Gail; Van De Lagemaat, Louie N.; Christoforou, Andrea; Marioni, Riccardo R.; Duarte Fernandes, Carla; Liewald, David Cherry; Croning, Mike D.R.; Payton, Anthony; Craig, Leone C.A.; Whalley, Lawrence J.; Horan, Michael; Ollier, William E.R.; Hansell, Narelle K.; Wright, Margaret J.; Martin, Nicholas G.; Montgomery, Grant W.; Steen, Vidar Martin; Le Hellard, Stephanie; Espeseth, Thomas; Lundervold, Astri; Reinvang, Ivar; Starr, John M.; Pendleton, Neil; Grant, Seth G.N.; Bates, Timothy C.; Deary, Ian John (Peer reviewed; Journal article, 2014)
      Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Genome-wide ...

    • Human Embryonic Development : Effects of Physical Activity and Sleep in Physiological Pregnancies 

      Vietheer, Alexander (Doctoral thesis, 2024-05-03)
      Bakgrunn: Forskningsfeltet "Developmental Origin of Health and Disease" (DOHaD) har vist hvor betydningsfull fosterutviklingen er for individets fremtidige helse og sykdomsrisiko. I senere år har den tidligste perioden av ...

    • Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins 

      DeForest, Natalie; Kavitha, Babu; Hu, Siqi; Isaac, Roi; Krohn, Lynne; Wang, Minxian; Du, Xiaomi; De Arruda Saldanha, Camila; Gylys, Jenny; Merli, Edoardo; Abagyan, Ruben; Najmi, Laeya Abdoli; Mohan, Viswanathan; Flannick, Jason; Peloso, Gina M.; Gordts, Philip L.S.M.; Heinz, Sven; Deaton, Aimee M.; Khera, Amit V.; Olefsky, Jerrold; Radha, Venkatesan; Majithia, Amit R. (Journal article; Peer reviewed, 2023)
      Loss-of-function mutations in hepatocyte nuclear factor 1A (HNF1A) are known to cause rare forms of diabetes and alter hepatic physiology through unclear mechanisms. In the general population, 1:100 individuals carry a ...

    • Human gingival epithelial cells stimulate proliferation, migration, and tube formation of lymphatic endothelial cells in vitro 

      Indrelid, Stine Hufthammer; Dongre, Harsh Nitin; Nunes, Ivana Pereira; Virtej, Anca; Bletsa, Athanasia; Berggreen, Ellen (Journal article; Peer reviewed, 2023)
      Objective The aim of this study was to investigate the response of gingival epithelial cells to microbial and inflammatory signals. Background The gingival epithelial barrier provides the first line of defense and ...

    • A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia 

      Szabo, Attila; Akkouh, Ibrahim Ahmed; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi M.; Smeland, Olav Bjerkehagen; Glover, Joel Clinton; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)
      While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ...

    • Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) 

      Lande, Asgeir; Fluge, Øystein; Strand, Elin Bolle; Flåm, Siri Tennebø; Sosa, Daisy Duarte; Mella, Olav; Egeland, Torstein; Saugstad, Ola Didrik; Lie, Benedicte Alexandra; Viken, Marte K (Journal article; Peer reviewed, 2020)
      The etiology and pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are unknown, and autoimmunity is one of many proposed underlying mechanisms. Human Leukocyte Antigen (HLA) associations are ...

    • Human mucosal IgA immune responses against enterotoxigenic escherichia coli 

      Riaz, Saman; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2020-08-29)
      Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines ...

    • Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants 

      Uusitalo, Maiju; Klenow, Martin Berg; Laulumaa, Saara; Blakeley, Matthew P.; Simonsen, Adam Cohen; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Peripheral myelin protein 2 (P2) is a fatty acid-binding protein expressed in vertebrate peripheral nervous system myelin, as well as in human astrocytes. Suggested functions of P2 include membrane stacking and lipid ...

    • Human myelin proteolipid protein structure and lipid bilayer stacking 

      Ruskamo, Salla; Raasakka, Arne; Pedersen, Jan Skov; Martel, Anne; Škubník, Karel; Darwish, Tamim; Porcar, Lionel; Kursula, Petri (Journal article; Peer reviewed, 2022)
      The myelin sheath is an essential, multilayered membrane structure that insulates axons, enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein (PLP) is the most abundant protein of ...

    • Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes 

      Drazic, Adrian; Varland, Sylvia (Journal article; Peer reviewed, 2021)
      N-terminal acetylation is an irreversible protein modification that primarily occurs co-translationally, and is catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). The NatC complex (NAA30–NAA35–NAA38) ...