Browsing Faculty of Medicine by Title
Now showing items 5388-5407 of 8877
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Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
(Journal article; Peer reviewed, 2020)Chronic cancer-related fatigue (CF) is a common and distressing condition in a subset of cancer survivors and common also after successful treatment of malignant lymphoma. The etiology and pathogenesis of CF is unknown, ... -
Metabolic and Epigenetic Regulation by Estrogen in Adipocytes
(Journal article; Peer reviewed, 2022-02-22)Sex hormones contribute to differences between males and females in body fat distribution and associated disease risk. Higher concentrations of estrogens are associated with a more gynoid body shape and with more fat storage ... -
Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study
(Peer reviewed; Journal article, 2019-12-04)Background: The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ... -
Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders
(Peer reviewed; Journal article, 2020)Background: We aimed at exploring potential pathophysiological processes across psychotic disorders, applying metabolomics in a large and well-characterized sample of patients and healthy controls. Methods: Patients with ... -
Metabolic effects of diet containing blue mussel (Mytilus edulis) and blue mussel-fed salmon in a mouse model of obesity
(Journal article; Peer reviewed, 2023)Alternative feed ingredients for farmed salmon are warranted due to increasing pressure on wild fish stocks. As locally farmed blue mussels may represent an environmentally sustainable substitute with a lower carbon ... -
Metabolic factors and the risk of small intestine cancers: Pooled study of 800 000 individuals in the metabolic syndrome and cancer project
(Journal article; Peer reviewed, 2021)To explore the largely unknown etiology of small intestine cancer, we examinedmetabolic factors and risk of small intestine cancer overall and by subtypes. Among404 220 women and 403 265 men in six European cohorts, we ... -
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
(Journal article; Peer reviewed, 2022)Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the ... -
Metabolic predictors of pain, fatigue, depression and quality of life in people with long-term type 1 diabetes—the Dialong study
(Journal article; Peer reviewed, 2022)Aim To examine associations of metabolic parameters (mean 30 years' time-weighted HbA1c and low-density lipoprotein-cholesterol [LDL-c], current methionine sulfoxide [MetSO], advanced glycation end products [AGEs], ... -
Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics
(Peer reviewed; Journal article, 2015-12)Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, but ... -
Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers
(Peer reviewed; Journal article, 2012-07-30)It is important to identify patients with Maturity-onset diabetes of the young (MODY) as a molecular diagnosis determines both treatment and prognosis. Genetic testing is currently expensive and many patients are therefore ... -
Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project
(Peer reviewed; Journal article, 2014-02-18)Background: Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC related ... -
Metabolic risk score and cancer risk: pooled analysis of seven cohorts
(Peer reviewed; Journal article, 2015)Background: There are few data on the joint influence of metabolic factors on risk of separate cancers. Methods: We analysed data on body mass index, blood pressure and plasma levels of glucose, total cholesterol and ... -
Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
(Journal article; Peer reviewed, 2023)Background: The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin resistance and type 2 diabetes, but implicated ... -
Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome
(Peer reviewed; Journal article, 2015-12)Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant ... -
The metabolic syndrome and cardiometabolic risk factors in children and adolescents: Associations between different anthropometric measurements and cardiometabolic risk factors
(Master thesis, 2015-05-15)Introduction: The prevalence of pediatric obesity has increased worldwide during the last decades, and is currently a serious health challenge, as it causes extensive health problems in terms of cardiovascular comorbidities ... -
Metabolic syndrome as a risk factor for total hip or knee replacement due to primary osteoarthritis: A prospective cohort study (the HUNT study and the Norwegian arthroplasty register)
(Peer reviewed; Journal article, 2018-01-10)Objective: Biochemical changes associated with obesity may accelerate osteoarthritis beyond the effect of mechanical factors. This study investigated whether metabolic syndrome and its components (visceral obesity, ... -
Metabolically (un)healthy obesity and risk of obesity-related cancers: a pooled study
(Journal article; Peer reviewed, 2023)Background Studies of obesity with or without metabolic aberrations, commonly termed metabolically unhealthy or healthy obesity, in relation to cancer risk are scarce. Methods We investigated body mass index (normal ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
(Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Metallionenivåer i blod fra pasienter med metall-mot-metall-hofteprotese
(Journal article; Peer reviewed, 2021)Bakgrunn: BHR-protese (Birmingham hip resurfacing) er satt inn i hoften til 445 personer i Norge. Bivirkninger av metallfrigjøring fra metall-mot-metall-leddflater av kobolt-krom-legering kan forekomme. Målet med studien ...