Browsing Faculty of Medicine by Title

Now showing items 6088-6107 of 8878

    • OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation 

      Yang, Mingyi; Lin, Xiaolin; Segers, Filip; Suganthan, Rajikala; Hildrestrand, Gunn Annette; Rinholm, Johanne Egge; Aas, Per Arne; Sousa, Mirta; Holm, Sverre; Bolstad, Nils; Warren, David; Berge, Rolf Kristian; Johansen, Rune Forstrøm; Yndestad, Arne; Kristiansen, Elise; Klungland, Arne; Gomez, Luisa Fernanda Luna; Eide, Lars; Halvorsen, Bente; Aukrust, Pål; Bjørås, Magnar (Journal article; Peer reviewed, 2020)
      Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ...

    • Oxygen concentration in inhaled gas and nitric oxide concentration in exhaled gas. Is nitric oxide concentration in exhaled gas a useful marker for exposure to hyperoxia? 

      Caspersen, Cecilie (Doctoral thesis, 2014-04-10)
      Background: Exposure to partial pressures of oxygen (PO2) higher than 50 kPa may result in toxic effects on the lungs with reduced vital capacity, maximal expiratory flow rates and diffusion capacity. The risk of developing ...

    • Oxygen saturation after birth in resuscitated neonates in Uganda: A video-based observational study 

      Larsson, Mårten; Höök, Susanna Myrnerts; Mpamize, Allan; Tylleskär, Thorkild; Lubulwa, Clare; Trevisanuto, Daniele; Elfving, Kristina; Pejovic, Nicolas (Journal article; Peer reviewed, 2022)
      Background Monitoring of peripheral capillary oxygen saturation (SpO2) during neonatal resuscitation is standard of care in high-resource settings, but seldom performed in low-resource settings. We aimed to measure SpO2 ...

    • Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts 

      Sletta, Kristine Yttersian; Tveitarås, Maria Kathrine; Lu, Ning; Svendsen, Agnete; Reed, Rolf K.; Garmann-Johnsen, Annette; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2017-08-23)
      Background: Tumor hypoxia is relevant for tumor growth, metabolism, resistance to chemotherapy and metastasis. We have previously shown that hyperoxia, using hyperbaric oxygen treatment (HBOT), attenuates tumor growth and ...

    • p53 protein biosignatures in acute myeloid leukemia 

      Ånensen, Nina (Doctoral thesis, 2006-03-10)
      p53 is a tumor suppressor protein often regarded as the guardian of the genome. It is a highly connected protein involved in many signaling processes in the cell. The inactivation of p53 through genetic mutations in TP53 ...

    • p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy 

      Haaland, Ingvild; Hjelle, Sigrun Margrethe; Reikvam, Håkon; Sulen, André; Ryningen, Anita; McCormack, Emmet; Bruserud, Øystein; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2021)
      p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic ...

    • Paediatric Contacts of Adult COVID-19 Patients: Clinical Parameters, Risk Factors, and Outcome 

      Farooq, Ammara; Sheikh, Taimur Khalil; Syed, Fibhaa; Mustafa, Tehmina (Journal article; Peer reviewed, 2021)
      Background. There is insufficient data in Pakistan and in South Asia regarding paediatric COVID-19 demographics and related parameters. The main aim of this study was to assess the paediatric population exposed to SARS-CoV-2 ...

    • Paediatric HIV-1 infection in Uganda. Natural history and early antiretroviral treatment response 

      Musoke, Philippa M. (Doctoral thesis, 2011-10-07)
      Paediatric HIV-1 infection remains a major problem for sub-Saharan Africa with over 1300 new infections daily. Infected children have a high mortality with 50% dying by 2 years of age. Access to antiretroviral therapy (ART) ...

    • Paediatric kidney stone surgery: state-of-the-art review 

      Jones, Charles Patrick W.; Keller, Etienne Xavier; Tzelves, Lazaros; Beisland, Christian; Somani, Bhaskar K; Gjengstø, Peder; Æsøy, Mathias S.; Ulvik, Øyvind (Journal article; Peer reviewed, 2023)
      While urolithiasis in children is rare, the global incidence is rising, and the volume of minimally invasive surgeries being performed reflects this. There have been many developments in the technology, which have supported ...

    • Paediatric surgical conditions in malawi-a cross-sectional nationwide household survey 

      Varela, Carlos Gomes; Viste, Asgaut; Young, Sven; Groen, Reinou S.; Ngoie, Leonard Banza; Nandi, Bip; Mkandawire, Nyengo; Moen, Bente Elisabeth (Journal article; Peer reviewed, 2021)
      Background Untreated surgical conditions may lead to lifelong disability in children. Treating children with surgical conditions may reduce long-term effects of morbidity and disability. Unfortunately, low- and middle-income ...

    • Paediatric Ureteroscopy (P-URS) reporting checklist: a new tool to aid studies report the essential items on paediatric ureteroscopy for stone disease 

      Jones, Charles Patrick Warburton; Ulvik, Øyvind; Beisland, Christian; Somani, Bhaskar K. (Journal article, 2023)
      The burden of urolithiasis in children is increasing and this is mirrored by the number of surgical interventions in the form of ureteroscopy (URS). There exist many challenges in performing this surgery for this special ...

    • The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase 

      Aubi Catevilla, Oscar; Prestegård, Karina Skjervheim; K C, Kunwar Jung; Shi, Tie-Jun; Ying, Ming; Grindheim, Ann Kari; Scherer, Tanja; Ulvik, Arve; McCann, Adrian; Spriet, Endy; Thöny, Beat; Martinez, Aurora (Journal article; Peer reviewed, 2021)
      Phenylketonuria (PKU) is caused by autosomal recessive variants in phenylalanine hydroxylase (PAH), leading to systemic accumulation of L-phenylalanine (L-Phe) that may reach neurotoxic levels. A homozygous Pah-R261Q mouse, ...

    • Pain and pain tolerance in whiplash-associated disorders:A population-based study 

      Myrtveit, Solbjørg Makalani; Skogen, Jens Christoffer; Sivertsen, Børge; Steingrímsdóttir, Ólöf Anna; Stubhaug, Audun; Nielsen, Christopher Sivert (Peer reviewed; Journal article, 2015)
      Background: Pain is a cardinal symptom in individuals with whiplash-associated disorders (WAD). We aimed to compare pain characteristics between individuals with WAD and individuals reporting chronic pain from other causes, ...

    • Pain and physical function among nursing home patients and people with dementia. Cross-sectional analyses from the COSMOS-trial 

      Mo, Ingunn Fleten (Master thesis, 2018-08-24)
      Background: Previous studies have shown how nursing home patients have poor physical functioning and are largely care dependent in activities of daily life. These patients have a high prevalence of pain and are mainly ...

    • Pain and quality of life in nursing home residents with dementia after admission – a longitudinal study 

      Helvik, Anne-Sofie; Bergh, Sverre; Saltyte Benth, Jurate; Borza, Tom; Husebø, Bettina Elisabeth Franziska; Tevik, Kjerstin Elisabeth (Journal article; Peer reviewed, 2023-09-27)
      Background: Pain in nursing home (NH) residents with dementia is commonly reported and may affect Quality of Life (QoL) negatively. Few longitudinal studies have explored how pain and QoL develop in NH residents with ...

    • The Pain Assessment in Impaired Cognition scale (PAIC15): A multidisciplinary and international approach to develop and test a meta-tool for pain assessment in impaired cognition, especially dementia 

      Kunz, Miriam; de Waal, Margot W. M.; Achterberg, Wilco P.; Gimenez-Llort, Lydia; Lobbezoo, Frank; Sampson, Elizabeth L.; van Dalen-Kok, Annelore H.; Defrin, Ruth; Invitto, Sara; Konstantinovic, Ljubica; Oosterman, Joukje; Petrini, Laura; van der Steen, Jenny T.; Strand, Liv Inger; de Tommaso, Marina; Zwakhalen, Sandra; Husebø, Bettina; Lautenbacher, Stefan (Journal article; Peer reviewed, 2020)
      Background: Over the last decades, a considerable number of observational scales have been developed to assess pain in persons with dementia. The time seems ripe now to build on the knowledge and expertize implemented in ...

    • Pain complaints after consecutive nights and quick returns in Norwegian nurses working three-shift rotation: an observational study 

      Katsifaraki, Maria; Nilsen, Kristian Bernhard; Christensen, Jan Olav; Wærsted, Morten; Knardahl, Stein; Bjorvatn, Bjørn; Härmä, Mikko; Matre, Dagfinn (Journal article; Peer reviewed, 2020)
      Objectives To determine whether nurses working consecutive night shifts, or short transitions between shifts (quick returns (QRs)), yielded higher risk for pain complaints when compared with regular morning shifts. Sleep ...

    • Pain in dementia 

      Achterberg, Wilco; Lautenbacher, Stefan; Husebø, Bettina; Erdal, Ane; Herr, Keela (Journal article; Peer reviewed, 2020)
      The ageing revolution is changing the composition of our society with more people becoming very old with higher risks for developing both pain and dementia. Pain is normally signaled by verbal communication, which becomes ...

    • Pain management in patients with dementia 

      Achterberg, Wilco P.; Pieper, Marjoleine J.C.; van Dalen-Kok, Annelore H.; de Waal, Margot W.M.; Husebø, Bettina; Lautenbacher, Stefan; Kunz, Miriam; Scherder, Erik J.A.; Corbett, Anne (Peer reviewed; Journal article, 2013-10-31)
      There are an estimated 35 million people with dementia across the world, of whom 50% experience regular pain. Despite this, current assessment and treatment of pain in this patient group are inadequate. In addition to the ...

    • Pain pressure threshold algometry in knee osteoarthritis: intra- and inter-rater reliability 

      Stausholm, Martin Bjørn; Bjordal, Jan Magnus; Moe-Nilssen, Rolf; Naterstad, Ingvill Fjell (Journal article; Peer reviewed, 2023)
      Introduction: Synovitis and effusion can cause pain sensitization in persons with knee osteoarthritis (KOA). Pain Pressure Threshold (PPT) algometry is a means to quantify somatosensory abnormalities, including ...