Browsing Faculty of Medicine by Title
Now showing items 7357-7376 of 8852
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The role of autoantibodies in cell mediated autoimmune Addison`s disease
(Master thesis, 2012-05-31)Background: Addison`s disease (primary adrenal insufficiency) is a prototypic organ-specific autoimmune disease affecting the adrenal cortex. Autoimmune Addison`s disease (AAD) is often characterized by autoantibodies ... -
The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis
(Master thesis, 2019-11-14) -
The role of Axl in melanoma metastasis
(Master thesis, 2015-05-31)Melanoma is a highly invasive and metastatic cancer, thus understanding the mechanism of melanoma metastasis is a major issue. In our study, the objective is to elucidate the role of the receptor tyrosine kinase Axl in ... -
Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma
(Master thesis, 2018-06-29)Glioblastomas (GBM), a grade IV astrocytoma, is the most common and aggressive primary brain tumors in adults, associated with short survival and uniformly fatal outcome irrespective of treatment. GBM is highly heterogeneous ... -
The Role of Diet in Irritable Bowel Syndrome with special reference to Gut Neuroendocrine System
(Doctoral thesis, 2015-08-28)Background: The majority of the patients with irritable bowel syndrome (IBS) believe that diet triggers their symptoms, which affect the quality of their lives. The pathophysiology of IBS is not exactly known, however, the ... -
The role of diet in the pathophysiology and management of irritable bowel syndrome
(Journal article; Peer reviewed, 2021)Irritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) disorder that reportedly affects 5% to 20% of the world population. The etiology of IBS is not completely understood, but diet appears to play an important ... -
Role of dietary carbohydrate quality and quantity in visceral obesity reduction : Results from a randomized controlled trial (CARBFUNC)
(Doctoral thesis, 2022-03-25)Background: Increased visceral adipose tissue (VAT) volume is associated with common lifestyle diseases and poses an increasing health challenge worldwide. There is a great need for effective approaches that result in ... -
The role of dietary fat and carbohydrates in development of adipose tissue inflammation
(Master thesis, 2009-06-02)Obesity is considered as a chronic low-grade inflammatory condition, which can be characterized by increased levels of the proinflammatory cytokines such as TNF-α and IL-6, and macrophage infiltration in adipose tissue. ... -
Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development
(Peer reviewed; Journal article, 2013-11-12)Background: Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. ... -
The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review
(Journal article; Peer reviewed, 2022)There is mounting evidence that environmental exposures can result in effects on health that can be transmitted across generations, without the need for a direct exposure to the original factor, for example, the effect of ... -
The role of evidence in the decision-making process of selecting essential medicines in developing countries: the case of Tanzania
(Peer reviewed; Journal article, 2014-01-08)Background: Insufficient access to essential medicines is a major health challenge in developing countries. Despite the importance of Standard Treatment Guidelines and National Essential Medicine Lists in facilitating ... -
Role of evolutionary conserved residues in integrin α11 cytoplasmic tail
(Master thesis, 2021-05-31)Integrins are cell surface receptors, present in the plasma membrane of cells. The integrin family is composed of 18 α subunits and 8 β subunits, which can combine non-covalently to form 24 different integrin heterodimers. ... -
The role of fat distribution and inflammation in the origin of endometrial cancer, study protocol of the ENDOCRINE study
(Journal article; Peer reviewed, 2022)Background Obesity is a growing problem worldwide, especially in countries with improved socioeconomic circumstances. Also, in the Netherlands the incidence of overweight and obesity is rising. There is increasing evidence ... -
Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort
(Journal article; Peer reviewed, 2023)Objectives This study aimed to explore the role of fungal burden in risk stratification of patients without HIV-negative patients with Pneumocystis pneumonia (PCP). Methods This was a retrospective analysis of the ... -
The role of Gastro Esophageal Reflux in Chronic Rhinosinusitis
(Doctoral thesis, 2019-06-20)Background: Chronic Rhino Sinusitis (CRS) is one of the most prevalent chronic disorders in industrialized countries. The disease has a major negative impact on quality of life, social and professional capacity as well as ... -
The role of general practitioners in the pre hospital setting, as experienced by emergency medicine technicians: a qualitative study
(Peer reviewed; Journal article, 2014-08-22)Background: Together with the ambulances staffed with emergency medical technicians (EMTs), general practitioners (GPs) on call are the primary resources for handling emergencies outside hospitals in Norway. The benefit ... -
Role of gingival lymphatics in tissue fluid balance and periodontal disease development
(Doctoral thesis, 2012-05-25)Background: The gingiva is frequently challenged to oral bacteria which are able to induce inflammatory responses with increased fluid filtration and edema formation in the tissue. Under given circumstances periodontal ... -
The role of imaging in anterior cruciate ligament reconstruction
(Doctoral thesis, 2021-08-27)The thesis is based on four articles examining the role of imaging after surgical reconstruction of the anterior cruciate ligament of the knee. Post-operative imaging is commonly performed to validate ACL graft tunnel ... -
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
(Journal article; Peer reviewed, 2023)Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the ... -
Role of integrin α11 in oral carcinogenesis. In vitro and in vivo studies
(Doctoral thesis, 2016-04-29)Cancer research has provided evidence for several advanced and better ways of treatment, helping the community for a better living. Nevertheless, for head and neck cancer there is still a long way to go for achieving an ...