Browsing Faculty of Medicine by Title
Now showing items 8407-8426 of 8871
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Tumor-associated macrophages in gliomas—basic insights and treatment opportunities
(Journal article; Peer reviewed, 2022)Glioma refers to a group of primary brain tumors which includes glioblastoma (GBM), astrocytoma and oligodendroglioma as major entities. Among these, GBM is the most frequent and most malignant one. The highly infiltrative ... -
Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s
(Journal article; Peer reviewed, 2020)Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a relatively small proportion of immune ... -
Tumor-penetrating peptide for systemic targeting of Tenascin-C
(Journal article; Peer reviewed, 2020)Extracellular matrix in solid tumors has emerged as a specific, stable, and abundant target for affinity-guided delivery of anticancer drugs. Here we describe the homing peptide that interacts with the C-isoform of Tenascin-C ... -
Tumour texture features from preoperative CT predict high-risk disease in endometrial cancer
(Journal article; Peer reviewed, 2021-01)Background: To enable more individualised treatment of endometrial cancer, improved methods for preoperative tumour characterization are warranted. Texture analysis is a method for quantification of heterogeneity in images, ... -
Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
(Peer reviewed; Journal article, 2017-02-07)Background: Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. Methods: We isolated stromal cells from patient-derived ... -
Tunneling nanotubes: Diversity in morphology and structure
(Peer reviewed; Journal article, 2014-02-06)Tunneling nanotubes (TNTs) are recently discovered thin membranous tubes that interconnect cells. During the last decade, research has shown TNTs to be diverse in morphology and composition, varying between and within cell ... -
Turnover of IPS employment specialists within the implementation of the evidence-based practice ‘Individual Placement and Support’
(Doctoral thesis, 2023-04-21)I skrivende stund er lav sysselsetting av personer med psykiske lidelser et globalt problematisert fenomen. Individuell jobbstøtte (IPS) er en manualisert metode for arbeidsrehabilitering som i et solid antall randomiserte ... -
Turnover of IPS employment specialists: Rates and predictors
(Journal article; Peer reviewed, 2022)Background: There are anecdotal reports of high job turnover of Individual Placement and Support employment specialists. However, no studies have addressed this issue. Objective: To explore whether turnover rates among ... -
Turnusordningar i helsevesenet - Erfaringar med kort kviletid mellom vakter hjå helsepersonell i todelt turnus: Ein fokusgruppeintervjustudie
(Master thesis, 2023-05-15)SAMANDRAG Bakgrunn: Helsepersonell i todelt turnus må ofte belage seg på å arbeide vaktkombinasjonen sein-tidleg, som gir kortare enn 11 timar kviletid mellom to vakter, «quick return». Quick return er relatert til fleire ... -
Tweeting the meeting: Quantitative and qualitative twitter activity during the 38th ESSO conference
(Peer reviewed; Journal article, 2019-02)Introduction: Social media is increasingly used to share information with the potential for fast and wide reach. Data on use during surgical oncology conferences is limited. We aimed to monitor twitter usage during a ... -
Twin Pregnancies: Long-term Maternal Mortality, Birthweight in Subsequent Pregnancy and Adverse Pregnancy Outcomes in Next Generation
(Doctoral thesis, 2024-04-15)Bakgrunn: Tvillingsvangerskap har vært mindre studert enn svangerskap med enkeltfødte. Ved å bruke populasjonsbaserte registerdata ønsket vi å belyse sammenheng mellom tvillingsvangerskap, reproduksjon og langtidsdødelig ... -
Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012
(Peer reviewed; Journal article, 2014-10-01)Background: The aim of the current study was to estimate sex- and age-specific incidence rates of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) using population-based registry data. CFS/ME is a debilitating ... -
Two interventions to treat pain disorders and post-traumatic symptoms among Syrian refugees: protocol for a randomized controlled trial
(Peer reviewed; Journal article, 2019)Background: There is a high prevalence of pain and post-traumatic symptoms among refugees and feasible interventions to manage these are needed. However, knowledge about the effect of physiotherapy and psychological group ... -
Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases
(Journal article; Peer reviewed, 2022)Context Maturity onset diabetes of the young, type 8 (MODY8) is associated with mutations in the CEL gene, which encodes the digestive enzyme carboxyl ester lipase. Several diabetes cases and families have in recent years ... -
Two tales of Annexin A2 knock-down: One of compensatory effects by antisense RNA and another of a highly active hairpin ribozyme
(Peer reviewed; Journal article, 2019-05-31)Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the progression of many cancer types and also plays key roles during viral infection and multiplication. Consequently, there ... -
Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK
(Peer reviewed; Journal article, 2014-11-20)BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ... -
Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial
(Peer reviewed; Journal article, 2019)Background: Digital breast tomosynthesis is an advancement of mammography, and has the potential to overcome limitations of standard digital mammography. This study aimed to compare first-generation digital breast ... -
Two-year changes in gait variability in community-living older adults
(Peer reviewed; Journal article, 2019-06-07)Background: Increases in stride-to-stride fluctuations (gait variability) are common among older adults, but little is known about the natural progression of gait variability with increasing age. Research question: Does ... -
A two-year longitudinal follow-up of cognitive performance assessed by BICAMS in newly diagnosed patients with MS
(Journal article; Peer reviewed, 2020)Background: Cognitive impairment is common in patients with multiple sclerosis (MS) and may occur at any stage and with any subtype of the disease. Screening and monitoring of cognitive function should therefore be implemented ... -
Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy
(Peer reviewed; Journal article, 2010-12-03)Background To examine the expression of type 1 plasminogen inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC), and its possible association with microvessel density (MVD), the expression of thrombospondin-1 ...