Blar i Faculty of Medicine på tittel
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Cross-Species Functional Genomic Analysis Identifies Resistance Genes of the Histone Deacetylase Inhibitor Valproic Acid
(Peer reviewed; Journal article, 2012-11-14)The mechanisms of successful epigenetic reprogramming in cancer are not well characterized as they involve coordinated removal of repressive marks and deposition of activating marks by a large number of histone and DNA ... -
A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets
(Peer reviewed; Journal article, 2019-06-18)High-throughput siRNA screens were only recently applied to cell factories to identify novel engineering targets which are able to boost cells towards desired phenotypes. While siRNA libraries exist for model organisms ... -
Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders
(Journal article; Peer reviewed, 2023)C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic liability to elevated CRP on schizophrenia risk and a causative ... -
Crosstalk between HSF1 and HSF2 during the heat shock response in mouse testes
(Peer reviewed; Journal article, 2014-12)Heat Shock Factor 1 (HSF1) is the primary transcription factor responsible for the response to cellularstress, while HSF2 becomes activated during development and differentiation, including spermatogen-esis. Although both ... -
Crowdsourcing in proteomics: public resources lead to better experiments
(Peer reviewed; Journal article, 2013-04)With the growing interest in the field of proteomics, the amount of publicly available proteome resources has also increased dramatically. This means that there are many useful resources available for almost all aspects ... -
Crucial aspects promoting meaning and purpose in life: perceptions of nursing home residents
(Peer reviewed; Journal article, 2017-10-30)Background: Meaning and purpose in life are fundamental to human beings. In changing times, with an aging population and increased life expectancy, the need for health care services and long-term care is likely to grow. ... -
Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice
(Journal article; Peer reviewed, 2020)Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human ... -
Cryoballoon vs. radiofrequency catheter ablation: insights from NOrwegian randomized study of PERSistent Atrial Fibrillation (NO-PERSAF study)
(Journal article; Peer reviewed, 2022)Aims Pulmonary vein isolation (PVI) is still regarded as a cornerstone for treatment of persistent atrial fibrillation (AF). This study evaluated the effectiveness of PVI performed with cryoballoon ablation (CBA) in ... -
Cryoneurolysis for cervicogenic headache - A double blinded randomized controlled study
(Journal article; Peer reviewed, 2020)Background and aims: Cervicogenic headache (CEH) is a debilitating condition and analgesics have limited effect. Percutaneous cryoneurolysis is thus still in use although the clinical evidence is lacking. We present a ... -
Cryptosporidiosis in low-resource healthcare settings : Near-patient diagnostics, risk factors, and parasite shedding dynamics in young Ethiopian children
(Doctoral thesis, 2023-04-28)Bakgrunn: Tarmparasitten Cryptosporidium er en ledende årsak til diaré og dødsfall hos småbarn i lavinntektsland. Målretta behandling trengs, men forutsetter presise diagnostiske tester som er egna for ressursfattige ... -
Cryptosporidium Infections in Africa—How Important Is Zoonotic Transmission? A Review of the Evidence
(Journal article; Peer reviewed, 2020)Cryptosporidium, a protozoan parasite in the phylum Apicomplexa, is the etiological agent of cryptosporidiosis, an intestinal infection characterized by profuse watery diarrhea. Over 30 species of Cryptosporidium are ... -
Crystal and solution structure of NDRG1, a membranebinding protein linked to myelination and tumour suppression
(Journal article; Peer reviewed, 2021)N-myc downstream-regulated gene 1 (NDRG1) is a tumour suppressor involved in vesicular trafficking and stress response. NDRG1 participates in peripheral nerve myelination, and mutations in the NDRG1 gene lead to ... -
Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc
(Journal article; Peer reviewed, 2021)Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms ... -
Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics
(Journal article; Peer reviewed, 2022)Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics. The enzyme catalyses the Claisen condensation of ... -
Crystallographic home-source X-ray data for the atomic-resolution experimental phasing of the Shank3 SH3 domain structure from pseudomerohedrally twinned crystals
(Peer reviewed; Journal article, 2018-10)By far most macromolecular crystallographic data collection and experimental phasing is nowadays carried out using synchrotron radiation. Here, we present two crystallographic datasets collected on a home-source X-ray ... -
CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis
(Journal article; Peer reviewed, 2021)Background Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data. Objective To test the long-term clinical and radiological ... -
CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test
(Journal article; Peer reviewed, 2021)Background Emphysema and exercise induced desaturation (EID) are both related to poorer COPD prognosis. More knowledge of associations between emphysema and desaturation is needed for more efficient disease management. ... -
ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab
(Peer reviewed; Journal article, 2019)Bevacizumab is included in an increasing number of clinical trials. To find biomarkers to predict and monitor treatment response, cancer and angiogenesis relevant mutations in tumour and circulating tumour DNA (ctDNA) were ... -
CTLA-4 as a genetic determinant in autoimmune Addison's disease
(Peer reviewed; Journal article, 2015)In common with several other autoimmune diseases, autoimmune Addison’s disease (AAD) is thought to be caused by a combination of deleterious susceptibility polymorphisms in several genes, together with undefined environmental ... -
Cultural beliefs and practices on perinatal death: a qualitative study among the Lango community in Northern Uganda
(Journal article; Peer reviewed, 2023)Background Perinatal death has profound psychosocial effects on women and their families. Sociocultural contexts influence the burden, rituals and bereaved’s support. Little is known about cultural beliefs and practices ...