Blar i Faculty of Medicine på tittel
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Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia
(Peer reviewed; Journal article, 2019)Purpose. Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ... -
Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo
(Master thesis, 2012-05-30)Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ... -
Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A
(Journal article; Peer reviewed, 2023-01-19)Diabetes is a metabolic disease that currently affects nearly half a billion people worldwide. β-cells dysfunction is one of the main causes of diabetes. Exposure to endocrine-disrupting chemicals is correlated with increased ... -
Molecular alterations suggesting new treatment strategies in uterine carcinomas
(Doctoral thesis, 2017-11-10) -
Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas
(Journal article; Peer reviewed, 2023)Background: High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain ... -
Molecular approaches to the diagnosis and evaluation of follicular lymphoma
(Doctoral thesis, 2015-05-27)Background: Molecular studies of immunoglobulin (IG) genes have provided insights into the pathogenesis of different lymphoid malignancies and allowed the development of useful diagnostic tools as well as powerful prognostic ... -
Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK
(Journal article; Peer reviewed, 2020-02)The human N-terminal acetyltransferase E (NatE) contains NAA10 and NAA50 catalytic, and NAA15 auxiliary subunits and associates with HYPK, a protein with intrinsic NAA10 inhibitory activity. NatE co-translationally acetylates ... -
Molecular biology in pancreatic ductal adenocarcinoma: implications for future diagnostics and therapy
(Peer reviewed; Journal article, 2019)Background: Novel technology has enabled researchers to better characterize pancreatic cancers at the molecular level. We wanted to explore some of the emerging discoveries, such as molecular subclassification, use of ... -
Molecular Biomarkers in Thyroid Eye Disease: A Literature Review
(Journal article; Peer reviewed, 2023)Purpose: Thyroid eye disease (TED) is the most common extrathyroidal manifestation of Graves disease. Patients may be severely affected with eyelid retraction, exophthalmos, diplopia, pain, and threatened vision. ... -
Molecular characterisation of the first New Delhi metallo-β-lactamase 1-producing Acinetobacter baumannii from Tanzania
(Journal article; Peer reviewed, 2021)Background We aimed to characterise the genetic determinants and context of two meropenem-resistant clinical isolates of Acinetobacter baumannii isolated from children hospitalised with bloodstream infections in Dar es ... -
The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2021)High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare but have a very poor prognosis and represent a severely understudied class of tumours. Molecular data for HG GEP-NEN are limited, and ... -
Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis
(Journal article; Peer reviewed, 2020-01-10)Background: We have reported that BRAF V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from ... -
Molecular characterization of antibiotic resistant bacteria in newly HIV diagnosed adults in a community setting in Tanzania. Implications for infection prevention and control in HIV : Antibiotic resistant bacteria, HIV, Community, Sub-Saharan Africa
(Doctoral thesis, 2022-08-26)Mennesker som lever med HIV-infeksjon i utviklingsland har økt risiko for å bli smittet med antibiotikaresistente bakterier. Høyere forbruk av antibiotika på grunn av HIV-relatert sykdom gir et seleksjonspress som kan føre ... -
Molecular characterization of Corynebacterium diphtheriae isolates, Russia, 1957-1987
(Peer reviewed; Journal article, 2002)In the 1990s, the Newly Independent and Baltic States of the former Soviet Union experienced the largest diphtheria outbreak since the 1960s; it was caused by Corynebacterium diphtheriae strains of a unique clonal group. ... -
Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs
(Peer reviewed; Journal article, 2014-08)Background: Despite detailed knowledge about the structure and signaling properties of individual collagen receptors, much remains to be learned about how these receptors participate in linking cells to fibrillar collagen ... -
Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer
(Peer reviewed; Journal article, 2012)We characterized tumor microenvironment (TME) components of mobile tongue (MT) cancer patients in terms of overall inflammatory infiltrate, focusing on the protumorigenic/anti-inflammatory phenotypes and on cancer-associated ... -
Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNA Leu(UUR))) gene
(Peer reviewed; Journal article, 2006-11-27)The gene encoding mt-tRNALeu(UUR), MT-TL1, is a hotspot for pathogenic mtDNA mutations. Amongst the first to be described was the 3302A>G transition which resulted in a substantial accumulation in patient muscle of RNA19, ... -
The Molecular Epidemiology of Enterovirus in a Birth Cohort in Nepal
(Journal article; Peer reviewed, 2023)Acute gastroenteritis (AGE) has a major impact on morbidity and mortality worldwide. The viral aetiology of diarrhoeal diseases may remain unknown due to limited diagnostic facilities. Non-polio enteroviruses (NPEVs) are ... -
Molecular markers to predict prognosis and guide therapy in endometrial cancer
(Doctoral thesis, 2020-02-07)Background: Endometrial cancer is the most common gynecological malignancy in the Western world. The disease occurs in the epithelial lining of the uterus, called the endometrium. Although prognosis is good and most of the ...