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Musculoskeletal impairment and road traffic injuries in Malawi
(Doctoral thesis, 2023-05-05)Introduction: The global burden of musculoskeletal disease in low and middle-income countries is large, growing, and neglected. While there is considerable funding for the control of communicable disease, there has been ... -
Musculoskeletal pain patterns and association between dizziness symptoms and pain in patients with long term dizziness – a cross-sectional study
(Journal article; Peer reviewed, 2023)Background The impact of long-term dizziness is considerable both on the personal level and in society and may lead to self-imposed restrictions in daily activities and social relations due to fear of triggering the ... -
Musculoskeletal sequelae in patients with obstetric fistula - a case-control study
(Peer reviewed; Journal article, 2014-11-08)Background: Obstetric fistula is essentially a result of pelvic injury caused by prolonged obstructed labour. Foot drop and walking difficulties in some of these women signify that the injury may extend beyond the loss of ... -
Musculoskeletal Symptoms in adults in Kathmandu Metropolitan City: A Household survey
(Master thesis, 2014-06-17)Objective: - To obtain information about musculoskeletal symptoms (MSS) in Kathmandu Metropolitan City (KMC), Nepal. Method: - A descriptive cross-sectional study was performed in KMC. There are 35 different wards (areas) ... -
Musical Breaks—Live Music in a Hemodialysis Setting—A Qualitative Study on Patient, Nurse, and Musician Perspectives
(Journal article; Peer reviewed, 2022)The aim of this hermeneutic-phenomenological study was to explore the perspectives of 12 patients, 17 nurses, and 4 musicians on patient-tailored live music interventions in a hemodialysis setting. Twenty-six semi-structured ... -
Muskel- og skjelettskader i brasiliansk jiu-jitsu: en systematisk oversikt
(Master thesis, 2022-11-18)Bakgrunn/hensikt: Brasiliansk jiu-jitsu er en kampsport hvor man prøver å ta kampen ned til bakken via felling eller kast, få kontroll over motstanderen, og få motstanderen til å gi seg via en kvelning eller leddlås. ... -
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin
(Peer reviewed; Journal article, 2019-12-16)IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), ... -
Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma
(Peer reviewed; Journal article, 2019-01-05)Background Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ... -
Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers
(Journal article; Peer reviewed, 2022)Purpose: The identification of patients with homologous recombination deficiency (HRD) beyond BRCA1/2 mutations is an urgent task, as they may benefit from PARP inhibitors. We have previously developed a method to detect ... -
Mutations and gene amplifications in Endometrial Carcinomas. “Clinical characteristics and potential targets for therapy related to KRAS, MYC, ATAD2, PIK3CA and FGFR2 alterations”
(Doctoral thesis, 2013-09-20)Background: Incidence of endometrial cancer is increasing in industrialised countries. Despite early diagnosis and generally good prognosis, around one fourth of cases follow an aggressive path with few effective treatment ... -
Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer
(Peer reviewed; Journal article, 2016-01-19)Background: Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC). SOX2 signaling is important in maintaining the stem cell-like phenotype ... -
Mutations of the p53 gene in oral squamous-cell carcinomas from sudanese dippers of nitrosamine-rich toombak and non-snuff-dippers from the Sudan and Scandinavia
(Journal article, 1999-11-08)Using PCR-SSCP/DNA sequencing methods, we analyzed 14 oral squamous-cell carcinomas (OSCCs) and 8 pre-malignant oral lesions from different Sudanese patients for prevalence of mutations in exons 5 to 9 of the p53 gene in ... -
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Clinical trials, medical treatment and pathomechanisms
(Doctoral thesis, 2024-05-02)Myalgisk encefalomyelitt/kronisk utmattelsessyndrom (ME/CFS) er en underprioritert sykdom som rammer 0,2-0,8 % av befolkningen, med ukjent etiologi, høy symptombelastning, ingen biomarkør, og ingen godkjent effektiv ... -
Myasthenia gravis can have consequences for pregnancy and the developing child
(Journal article; Peer reviewed, 2020)Myasthenia gravis (MG) with onset below 50 years, thymic hyperplasia and acetylcholine receptor (AChR) antibodies is more common in females than in males. For a relatively large group of MG patients, pregnancy represents ... -
Myasthenia gravis, respiratory function, and respiratory tract disease
(Journal article; Peer reviewed, 2023)Myasthenia gravis (MG) is characterized by muscle weakness caused by autoantibodies that bind to the postsynaptic membrane at the neuromuscular junction and impair acetylcholine receptor function. Weakness of respiratory ... -
Myasthenia gravis; cytotoxic potential of human sera in vitro and novel non-antibody, disease-modifying factors
(Doctoral thesis, 2010-10-22) -
MYC-induced miR-203b-3p and miR-203a-3p control Bcl-xL expression and paclitaxel sensitivity in tumor cells
(Peer reviewed; Journal article, 2018)Taxanes are chemotherapeutic agents used in the treatment of solid tumors, particularly of breast, ovarian, and lung origin. However, patients show divergent therapy responses, and the molecular determinants of taxane ... -
Mycobacteria in northern Tanzania: Exposure and risk of disease among agropastoralists and programmatic challenges in investigation of re-treatment cases
(Doctoral thesis, 2016-06-14)Background: The genus mycobacterium includes several species that can cause disease. Mycobacterium tuberculosis-complex is transmitted from person to person by air and usually affects the lungs. Non-tuberculous mycobacteria ... -
Mycobacterial antigen MPT64 specific polyclonal antibody production and validation for an immunohistochemistry based diagnostic test for extrapulmonary tuberculosis
(Master thesis, 2020-06-27)Mycobacterial antigen MPT64 specific polyclonal antibody production and validation for an immunohistochemistry based diagnostic test for extrapulmonary tuberculosis Background: Tuberculosis (TB) is a major health problem, ...