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The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells
(Peer reviewed; Journal article, 2019-10-02)Monocyte-derived dendritic cells (moDC) are an important scientific and clinical source of functional dendritic cells (DC). However, the optimization of the generation process has to date mainly been limited to the variation ... -
Cumulative incidence of sickness absence and disease burden among the newly sick-listed, a cross-sectional population-based study
(Peer reviewed; Journal article, 2013-04-10)Background: Sickness absence is a public health problem with economic consequences for individuals and society. Although sickness absence and chronic diseases are correlated, few studies exist concerning the role of chronic ... -
Cumulative prognostic score predicting mortality in patients older than 80 years admitted to the ICU
(Peer reviewed; Journal article, 2019-06)OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of ... -
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis
(Journal article; Peer reviewed, 2021)Two pathophysiological different experimental models for multiple sclerosis were analyzed in parallel using quantitative proteomics in attempts to discover protein alterations applicable as diagnostic-, prognostic-, or ... -
Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers
(Peer reviewed; Journal article, 2010-09)Background: Reported prevalence, penetrance and expression of deleterious mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 and PMS2, may reflect differences in the clinical criteria used to select families ... -
Current evidence on basic emergency obstetric and newborn care services in Addis Ababa, Ethiopia; a cross sectional study
(Peer reviewed; Journal article, 2014-10-10)Background: Emergency obstetric and neonatal care (EmONC) is a high impact priority intervention highly recommended for improving maternal and neonatal health outcomes. In 2008, Ethiopia conducted a national EmONC survey ... -
Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials
(Journal article; Peer reviewed, 2021)Background Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest ... -
Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis
(Journal article; Peer reviewed, 2021)Brain metastasis (BM) is a major cause of cancer patient morbidity. Clinical magnetic resonance imaging (MRI) and positron emission tomography (PET) represent important resources to assess tumor progression and treatment ... -
Current role of endoscopic combined intrarenal surgery in the management of renal stones: A scoping review
(Journal article; Peer reviewed, 2023)Introduction: This study aims to review the current role of endoscopic combined intrarenal surgery (ECIRS) in the management of renal stones, with a focus on its efficacy and safety. The secondary outcome was to highlight ... -
Current status of fecal microbiota transplantation for irritable bowel syndrome
(Journal article; Peer reviewed, 2021)Background Irritable bowel syndrome (IBS) is a common gastrointestinal functional disorder. Although IBS is a benign condition, it reduces the quality of life considerably. While there is currently no effective treatment ... -
Current Status of Intravesical Therapies for Bladder Pain Syndrome (BPS): A Narrative Review of Emerging Evidence
(Journal article; Peer reviewed, 2021)Bladder pain syndrome (BPS) is a complex condition, which can have debilitating sequelae for patients. Many elements of BPS remain poorly understood including pathophysiology, diagnosis and treatment. Navigating patient ... -
Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study
(Peer reviewed; Journal article, 2011-10-21)Background: Prevention of mother to child HIV transmission (PMTCT) programmes have great potential to achieve virtual elimination of perinatal HIV transmission provided that PMTCT recommendations are properly followed. ... -
Current status of nomograms and scoring systems in paediatric endourology: A systematic review of literature
(Journal article; Peer reviewed, 2022)Introduction The incidence of paediatric kidney stone disease is increasing worldwide, with the requirement for endourological interventions mirroring this. Multiple nomograms, grading tools and scoring systems now exist ... -
Current status of thulium fibre laser lithotripsy: an up-to-date review
(Journal article; Peer reviewed, 2021)Objective To perform an up-to-date review to scope the current status of the thulium fibre laser (TFL) in the setting of stone lithotripsy and provide a guide for the clinical urologist. Methods A review of world ... -
Current Status of Ureteric Stents on Extraction Strings and Other Non-cystoscopic Removal Methods in the Paediatric Setting: A Systematic Review on Behalf of the European Association of Urology (EAU) Young Academic Urology (YAU) Urolithiasis Group
(Journal article; Peer reviewed, 2022)Ureteric stents are an important tool in urology and have a wide range of indications. While they offer a number of advantages, limitations remain despite modern advancements. These include discomfort, migration and ... -
Current transfusion practice and need for new blood products to ensure blood supply for patients with major hemorrhage in Europe
(Journal article; Peer reviewed, 2023)Background: New blood products are considered for treatment of patients with major hemorrhage. The aim of this report is to describe the current transfusion practices in Europe for patients with major hemorrhage and explore ... -
Curriculum factors influencing knowledge of communication skills among medical students
(Peer reviewed; Journal article, 2007-10-10)Background: Communication training builds on the assumption that understanding of the concepts related to professional communication facilitates the training. We know little about whether students' knowledge of clinical ... -
The curse of the uncultured fungus
(Journal article; Peer reviewed, 2022)The international DNA sequence databases abound in fungal sequences not annotated beyond the kingdom level, typically bearing names such as “uncultured fungus”. These sequences beget low-resolution mycological results and ... -
Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4)
(Peer reviewed; Journal article, 2015-03-24)Tetrahydrobiopterin (BH4) is the natural cofactor of several enzymes widely distributed among eukaryotes, including aromatic amino acid hydroxylases (AAAHs), nitric oxide synthases (NOSs), and alkylglycerol monooxygenase ... -
Cutpoints for mild, moderate and severe pain in patients with osteoarthritis of the hip or knee ready for joint replacement surgery
(Peer reviewed; Journal article, 2008-04-21)Background Cutpoints (CPs) for mild, moderate and severe pain are established and used primarily in cancer pain. In this study, we wanted to determine the optimal CPs for mild, moderate, and severe pain in joint replacement ...