Blar i Faculty of Medicine på tittel
Viser treff 1833-1852 av 8854
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Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia
(Journal article; Peer reviewed, 2023)Congenital hyperinsulinism of infancy (CHI) can be caused by a deficiency of the ubiquitously expressed enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). To test the hypothesis that SCHAD-CHI arises from a specific ... -
Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta
(Peer reviewed; Journal article, 2014-02-19)Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ... -
Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
(Journal article; Peer reviewed, 2023)Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with ... -
Defining the Ethiopian Essential Health Service Package : Process, methods and cost-effectiveness evidence for the prioritisation of health interventions
(Doctoral thesis, 2021-06-15)Background: All countries have signed up to the United Nations (UN) Sustainable Development Goals (SDGs), including Target 3.8 on achieving universal health coverage (UHC). UHC is realised when everyone has access to quality ... -
Defining Transabdominal Intestinal Ultrasound Treatment Response and Remission in Inflammatory Bowel Disease: Systematic Review and Expert Consensus Statement
(Journal article; Peer reviewed, 2021)Background and Aims No consensus exists on defining intestinal ultrasound response, transmural healing, or transmural remission in inflammatory bowel disease, nor clear guidance for optimal timing of assessment during ... -
Defining when specialised mental health care is needed: A focus group study
(Journal article; Peer reviewed, 2020)Background: Shared understanding between GPs and hospital specialists concerning when patients need specialised mental health care is important to ensure patients receive appropriate care. The large amount of rejected ... -
The definition of immigrant status matters: impact of nationality, country of origin, and length of stay in host country on mortality estimates
(Peer reviewed; Journal article, 2019-02-28)Background: Mortality is a robust indicator of health and offers valuable insight into the health of immigrants. However, mortality estimates can vary significantly depending on the manner in which immigrant status is ... -
Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv
(Peer reviewed; Journal article, 2010-04-29)Background Membrane- and membrane-associated proteins are important for the pathogenicity of bacteria. We have analysed the content of these proteins in virulent Mycobacterium tuberculosis H37Rv using Triton X-114 ... -
Deformation and initial stability in hip arthroplasty. Effect of neck geometry and fixation – an experimental cadaver study
(Doctoral thesis, 2017-06-08)Introduction: The search for and development of the optimal joint implant include preclinical testing. Restoration of the individual and natural biomechanics in the hip joint is a central goal in hip arthroplasty, and can ... -
Degenerative bony changes in the temporal component of the temporomandibular joint – review of the literature
(Journal article; Peer reviewed, 2022)Temporomandibular joint (TMJ) changes are quite frequent in adults, but not all changes are degenerative. A high prevalence of bone alterations in the TMJs was reported by different research groups. Disturbed remodeling ... -
Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells
(Peer reviewed; Journal article, 2019-11-29)Nicotinamide adenine dinucleotide (NAD) is an essential redox carrier, whereas its degradation is a key element of important signaling pathways. Human cells replenish their NAD contents through NAD biosynthesis from ... -
Delay in the Diagnosis of Tuberculosis in Banke district, Nepal
(Master thesis, 2008-05-27)Background: Tuberculosis is one of the major causes of ill health in the world and almost 33% of the global new case was found in South East Asian Region. In 2006, tuberculosis incidence was reported 30,000 and 14,000 of ... -
Delay in the diagnosis of tuberculosis in Nepal
(Peer reviewed; Journal article, 2009-07-14)Background: Identifying reasons for delay in diagnosis and treatment of tuberculosis is important for the health system to find ways to treat patients as early as possible, and hence reduce the suffering of patients and ... -
Delay in Tuberculosis case detection in Pwani region, Tanzania. a cross sectional study
(Peer reviewed; Journal article, 2009-10-29)Background: Delay in Tuberculosis (TB) case detection may worsen the disease and increase TB transmission. It is also a challenge to the National TB and Leprosy control Program (NTLP). Methods: We conducted a cross sectional ... -
Delayed Sleep Phase Disorder in Adolescence and Young Adulthood. Patients` experiences, personality and treatment effects on daytime function
(Doctoral thesis, 2013-11-26)Delayed sleep phase disorder (DSPD) is a circadian rhythm sleep disorder where the sleep period is delayed compared to conventional norms. Patients with DSPD typically report complaints of excessive daytime sleepiness and ... -
Delayed Sleep Phase Disorder. Prevalence, sleep, circadian rhythm and treatment
(Doctoral thesis, 2013-04-30)Adolescence is often characterized by delayed and irregular sleep patterns, with potential negative consequences in terms of school performance and daytime functioning. At the most extreme, a stably delayed sleep phase may ... -
Delegated discretion: A call for reasonableness in surrogate decision-making and clinical judgment
(Doctoral thesis, 2009-01-30)In a democratic welfare state, how should individual judgment be exercised and constrained when someone is making decisions on behalf of another who is not considered competent to make his or her own decisions? How should ... -
Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca2+ Entry
(Journal article; Peer reviewed, 2022)Notch3 plays an important role in the differentiation and development of vascular smooth muscle cells. Mice lacking Notch3 show deficient renal autoregulation. The aim of the study was to investigate the mechanisms involved ... -
Delineating cellular and molecular mechanisms of toxicity of an extract of khat (Catha edulis Forsk.) in leukemia and normal peripheral blood cells
(Doctoral thesis, 2010-05-07)Plants have been used in treatment and prevention of diseases for thousands of years. In modern medicine there is a trend towards isolation and identification of bioactive molecules, whereas plant preparations continue to ... -
Delirium after Aortic Valve Therapy. A Prospective Cohort Study of Octogenarian Patients following Surgical Aortic Valve Replacement and Transcatheter Aortic Valve Implantation.
(Doctoral thesis, 2016-08-25)Introduction: Untreated and symptomatic aortic stenosis (AS) is associated with high mortality. Surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) are two treatment options for ...