Browsing Faculty of Medicine by Title
Now showing items 2328-2347 of 9103
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DrugPred_RNA—A Tool for Structure-Based Druggability Predictions for RNA Binding Sites
(Journal article; Peer reviewed, 2021)RNA is an emerging target for drug discovery. However, like for proteins, not all RNA binding sites are equally suited to be addressed with conventional drug-like ligands. To this end, we have developed the structure-based ... -
Drusenoid pigment epithelial detachment volume is associated with a decrease in best-corrected visual acuity and central retinal thickness: the Norwegian Pigment Epithelial Detachment Study (NORPED) report no. 1
(Journal article; Peer reviewed, 2020)Purpose To investigate the association of drusenoid pigment epithelial detachment (DPED) volume and change in best‐corrected visual acuity (BCVA) and central retinal thickness (CRT) during the growth phase of large ... -
The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs
(Journal article; Peer reviewed, 2022)Clear evidence shows that tumors could secrete microRNAs (miRNAs) via exosomes to modulate the tumor microenvironment (TME). However, the mechanisms sorting specific miRNAs into exosomes are still unclear. In order to study ... -
Duodenal administered seal oil for patients with subjective food hypersensitivity: an explorative open pilot study
(Peer reviewed; Journal article, 2010-12)Short-term duodenal administration of n-3 polyunsaturated fatty acid (PUFA)-rich seal oil may improve gastrointestinal complaints in patients with subjective food hypersensitivity, as well as joint pain in patients with ... -
Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome
(Peer reviewed; Journal article, 2014-06-16)Background and Aim. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with irritable bowel syndrome (IBS). Methods. The present study was undertaken to ... -
Durable immune responses after BNT162b2 vaccination in home-dwelling old adults
(Journal article; Peer reviewed, 2023)Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ... -
Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients
(Journal article; Peer reviewed, 2022)Background Neutralizing antibodies are important for protection against the pandemic SARS-CoV-2 virus, and long-term memory responses determine the risk of re-infection or boosting after vaccination. T-cellular responses ... -
Duration of elevated heart rate Is an important predictor of exercise-induced troponin elevation
(Journal article; Peer reviewed, 2020)Background The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase by ... -
Dust exposure and chronic respiratory symptoms among coffee curing workers in Kilimanjaro: a cross sectional study
(Peer reviewed; Journal article, 2011-11-24)Background: Coffee processing causes organic dust exposure which may lead to development of respiratory symptoms. Previous studies have mainly focused on workers involved in roasting coffee in importing countries. This ... -
Dust exposure and respiratory health among Tanzanian coffee factory workers
(Doctoral thesis, 2013-09-27)Introduction: Exposure to organic dust may cause detrimental effects to the respiratory system of exposed workers. Organic dust is commonly contaminated with microbes and their derivatives such as bacteria and endotoxin, ... -
Dust Exposure and Respiratory Health Among Workers in Primary Coffee Processing Factories in Tanzania and Ethiopia
(Journal article; Peer reviewed, 2021)Introduction: In primary coffee factories the coffee beans are cleaned and sorted. Studies from the 80- and 90-ties indicated respiratory health effects among the workers, but these results may not represent the present ... -
Dust exposure and respiratory health problems in a labour-intensive coal mine in Tanzania
(Doctoral thesis, 2006-12-05)Dust exposure and respiratory health problems were studied among randomly selected workers in a coal mine in Tanzania. The aim of the study was to assess the personal respirable dust and quartz exposure and the prevalence ... -
Duty to treat and perceived risk of contagion during the COVID-19 pandemic: Norwegian physicians’ perspectives and experiences—a questionnaire survey
(Journal article; Peer reviewed, 2022)Background The COVID-19 pandemic actualised the dilemma of how to balance physicians´ obligation to treat patients and their own perceived risk of being infected. To discuss this in a constructive way we need empirical ... -
Dwarfism in mice lacking collagen-binding integrins alpha 2 beta 1 and alpha 11 beta 1 is caused by severely diminished IGF-1 levels
(Peer reviewed; Journal article, 2012-02)Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with inconspicuous differences in size but develop dwarfism within the first 4 weeks of life. ... -
Dying at home in Norway: Health care service utilization in the final months of life
(Doctoral thesis, 2020-06-18)Background: Although many people prefer to die at home, few people die at home in Norway. We know little about sociodemographic characteristics of people who die at home, the extent of palliative end of life care provided ... -
Dying with dignity – Dignity-preserving care for older women living with incurable cancer at home
(Doctoral thesis, 2021-12-08)Background: the global population is ageing rapidly and most older people are women. They live longer than men, report more illnesses and have a poorer health status. When living with incurable cancer, gender perspectives ... -
Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo
(Peer reviewed; Journal article, 2017-05-10)Activity-regulatedcytoskeleton-associated protein (Arc) protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are ... -
Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma
(Peer reviewed; Journal article, 2014-09-30)There are currently no established radiological parameters that predict response to immunotherapy. We hypothesised that multiparametric, longitudinal magnetic resonance imaging (MRI) of physiological parameters and ... -
Dynamic contrast-enhanced MRI shows altered blood–brain barrier function of deep gray matter structures in neuroborreliosis: a case–control study
(Journal article; Peer reviewed, 2023)Background Main aim was assessment of regional blood–brain barrier (BBB) function by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with neuroborreliosis. Secondary aim was to study the correlation ... -
Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls
(Peer reviewed; Journal article, 2019)Introduction: Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators ...