Blar i Faculty of Medicine på tittel

Viser treff 256-275 av 8854

    • Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia 

      Banerjee, Niladri; Polushina, Tatiana; Bettella, Francesco; Steen, Vidar Martin; Andreassen, Ole Andreas; Le Hellard, Stephanie (Peer reviewed; Journal article, 2018-12-11)
      Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ...

    • Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections 

      Jahagirdar, Sanjeevan; Morris, Lorna; Benis, Nirupama; Oppegaard, Oddvar; Svenson, Mattias; Hyldegaard, Ole; Skrede, Steinar; Norrby-Teglund, Anna; Bruun, Trond; Rath, Eivind; Nedrebø, Torbjørn; Arnell, Per; Rosen, Anders; Hedetoft, Morten; Madsen, Martin B.; Svensson, Mattias; Snäll, Johanna; Karlsson, Ylva; Nekludov, Michael; Martins dos Santos, Vitor A. P.; Saccenti, Edoardo (Journal article; Peer reviewed, 2022)
      Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ...

    • Analysis of mortality metrics associated with a comprehensive range of disorders in Denmark, 2000 to 2018: A population-based cohort study 

      Plana-Ripoll, Oleguer; Dreier, Julie W.; Momen, Natalie C.; Prior, Anders; Weye, Nanna; Mortensen, Preben Bo; Pedersen, Carsten B.; Iburg, Kim Moesgaard; Christensen, Maria Klitgaard; Laursen, Thomas Munk; Agerbo, Esben; Pedersen, Marianne G.; Brandt, Jørgen; Frohn, Lise Marie; Geels, Camilla; Christensen, Jesper H.; McGrath, John J. (Journal article; Peer reviewed, 2022-06-16)
      Background: The provision of different types of mortality metrics (e.g., mortality rate ratios [MRRs] and life expectancy) allows the research community to access a more informative set of health metrics. The aim of this ...

    • Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations with DMD, FGF13, EGFL6, and Additional Loci at Xp22.2 

      Skare, Øivind; Lie, Rolv T.; Haaland, Øystein Ariansen; Gjerdevik, Miriam; Romanowska, Julia; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2018-02-22)
      Background: Although both the mother's and father's alleles are present in the offspring, they may not operate at the same level. These parent-of-origin (PoO) effects have not yet been explored on the X chromosome, which ...

    • Analysis of Plasmodium falciparum myosin B ATPase activity and structure in complex with the calmodulin-like domain of its light chain MLC-B 

      Pires, Isa; Hung, Yu-Fu; Bergmann, Ulrich; Molloy, Justin E.; Kursula, Inari (Journal article; Peer reviewed, 2022)
      Myosin B (MyoB) is a class 14 myosin expressed in all invasive stages of the malaria parasite, Plasmodium falciparum. It is not associated with the glideosome complex that drives motility and invasion of host cells. During ...

    • Analysis of role-play in medical communication training using a theatrical device the fourth wall 

      Jacobsen, Torild; Bærheim, Anders; Lepp, Margret Rose; Schei, Edvin (Peer reviewed; Journal article, 2006-10-14)
      Background: Communication training is a central part of medical education. The aim of this article is to explore the positions and didactic functions of the fourth wall in medical communication training, using a role-play ...

    • Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival 

      Mohamed, Nazar; Litlekalsøy, Jorunn; Ahmed, Israa Abdul Rhman; Martinsen, Einar Marius Hjellestad; Furriol, Jessica; Javier-Lopez, Ruben; Elsheikh, Mariam; Mohamed, Nuha Mohamed Gaafar; Morgado, Luis; Mundra, Sunil; Johannessen, Anne Christine; Osman, Tarig Al-Hadi; Nginamau, Elisabeth Sivy; Suleiman, Ahmed; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-10-12)
      Background: Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the ...

    • Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets 

      Postema, Merel C.; Hoogman, Martine; Ambrosino, Sara; Asherson, Philip; Banaschewski, Tobias; Bandeira, Cibele E.; Baranov, Alexandr; Bau, Claiton H.D.; Baumeister, Sarah; Baur-Streubel, Ramona; Bellgrove, Mark A.; Biederman, Joseph; Bralten, Janita; Brandeis, Daniel; Brem, Silvia; Buitelaar, Jan K.; Busatto, Geraldo F.; Castellanos, Francisco X.; Cercignani, Mara; Chaim-Avancini, Tiffany M.; Chantiluke, Kaylita C.; Christakou, Anastasia; Coghill, David; Conzelmann, Annette; Cubillo, Ana; Cupertino, Renata B.; de Zeeuw, Patrick; Doyle, Alysa E.; Durston, Sarah; Earl, Eric A.; Epstein, Jeffery N.; Ethofer, Thomas; Fair, Damien A.; Fallgatter, Andreas J.; Faraone, Stephen V.; Frodl, Thomas; Gabel, Matt C.; Gogberashvili, Tinatin; Grevet, Eugenio H.; Haavik, Jan; Harrison, Neil A.; Hartman, Catharina A.; Heslenfeld, Dirk J.; Hoekstra, Pieter J.; Hohmann, Sarah; Høvik, Marie Farstad; Jernigan, Terry L.; Kardatzki, Bernd; Karkashadze, George A.; Kelly, Clare; Kohls, Gregor; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lera-Miguel, Sara; Lesch, Klaus-Peter; Louza, Mario R.; Lundervold, Astri J.; Malpas, Charles B.; Mattos, Paulo; McCarthy, Hazel; Namazova-Baranova, Leyla; Nicolau, Rosa; Nigg, Joel T.; Novotny, Stephanie E.; Oberwelland Weiss, Eileen; O'Gorman Tuura, Ruth L.; Oosterlaan, Jaap; Oranje, Bob; Paloyelis, Yannis; Pauli, Paul; Picon, Felipe A.; Plessen, Kerstin J.; Ramos-Quiroga, J. Antoni; Reif, Andreas; Reneman, Liesbeth; Rosa, Pedro G.P.; Rubia, Katya; Schrantee, Anouk; Schweren, Lizanne J.S.; Seitz, Jochen; Shaw, Philip; Silk, Tim J.; Skokauskas, Norbert; Soliva, Joan Carles; Stevens, Michael C.; Sudre, Gustavo; Tamm, Leanne; Tovar-Moll, Fernanda; van Erp, Theo G.M.; Vance, Alasdair; Vilarroya, Oscar; Vives-Gilabert, Yolanda; von Polier, Georg G.; Walitza, Susanne; Yoncheva, Yuliya N.; Zanetti, Marcus V; Ziegler, Georg C.; Glahn, David C.; Jahanshad, Neda; Medland, Sarah E.; Thompson, Paul M.; Fisher, Simon E.; Franke, Barbara; Francks, Clyde (Journal article; Peer reviewed, 2021)
      Objective Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the ...

    • Analytical considerations in deriving 99th percentile upper reference limits for high-sensitivity cardiac troponin assays: Educational recommendations from the IFCC committee on clinical application of cardiac bio-markers 

      Aakre, Kristin Moberg; Saenger, Amy K.; Body, Rick; Collinson, Paul; Hammarsten, Ola; Jaffe, Allan S.; Kavsak, Pete; Omland, Torbjørn; Ordonez-Lianos, Jordi; Apple, Fred S. (Journal article; Peer reviewed, 2022)
      The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers provides evidence-based educational documents to facilitate uniform interpretation and utilization of cardiac ...

    • Analytical performance of cardiac troponin assays – Current status and future needs 

      Aakre, Kristin Moberg; Saeed, Nasir; Wu, Alan H.B.; Kavsak, Peter A. (Journal article; Peer reviewed, 2020)
      Concurrent with the introduction of cardiac troponin measurements into the diagnostic definition of myocardial infarction (MI), clinicians and laboratory professionals signaled a clear clinical need for improved analytical ...

    • Analytical quality control of INR measurements in primary care 

      Stavelin, Anne (Doctoral thesis, 2013-11-29)
      In Norway, most patients on oral anticoagulation with warfarin are treated in primary care. The treatment is monitored with the laboratory method prothrombin time, expressed as International normalized Ratio (INR). It is ...

    • Analyzing the Structure of Pathways and Its Influence on the Interpretation of Biomedical Proteomics Data Sets 

      Burger, Bram; Hernández Sánchez, Luis Francisco; Lereim, Ragnhild Reehorst; Barsnes, Harald; Vaudel, Marc (Peer reviewed; Journal article, 2018)
      Biochemical pathways are commonly used as a reference to conduct functional analysis on biomedical omics data sets, where experimental results are mapped to knowledgebases comprising known molecular interactions collected ...

    • Anaphylaxis following prick-by-prick testing with peanut 

      Alnæs, Marie (Journal article; Peer reviewed, 2020)
      Anaphylaxis due to prick‐by‐prick testing is a rare but potentially life‐threatening complication. Personnel performing testing should be able to recognize and treat anaphylaxis. Adrenaline must be available. In high‐risk ...

    • Anastomotic leak after surgery for colon cancer and effect on long‐term survival 

      Stormark, Kjartan; Krarup, Peter-Martin; Sjövall, Annika; Søreide, Kjetil; Kvaløy, Jan Terje; Nordholm-Carstensen, Andreas; Nedrebø, Bjørn Steinar Olden; Kørner, Hartwig (Journal article; Peer reviewed, 2020)
      Aim An anastomotic leak after surgery for colon cancer is a recognized complication but how it may adversely affect long‐term survival is less clear because data are scarce. The aim of the study was to investigate the ...

    • The anatomic centers of the femoral and tibial insertions of the anterior cruciate ligament: a systematic review of imaging and cadaveric studies reporting normal center locations 

      Parkar, Anagha P; Adriaensen, Miraude E.A.M.P.; Vindfeld, Søren; Solheim, Eirik (Journal article; Peer reviewed, 2016)
      Background: The anterior cruciate ligament (ACL) is regularly reconstructed if knee joint function is impaired. Anatomic graft tunnel placement, often assessed with varying measurement methods, in the femur and tibia is ...

    • Anatomy and evolution of database search engines — a central component of mass spectrometry based proteomic workflows 

      Verheggen, Kenneth; Ræder, Helge; Berven, Frode; Martens, Lennart Martens; Barsnes, Harald; Vaudel, Marc (Peer reviewed; Journal article, 2017-09-13)
      Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass ...

    • ANCA-associated glomerulonephritis. Prognostic factors and outcome in a Norwegian cohort 

      Sriskandarajah, Sanjeevan (Doctoral thesis, 2018-02-16)
      Objective. The objective of this dissertation is to (I) explore the temporal survival and identify prognostic factors in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis with renal affection, ...

    • Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans 

      Nepal, Chirag; Taranta, Andrzej; Hadzhiev, Yavor; Pundhir, Sachin; Mydel, Piotr Mateusz; Lenhard, Boris; Müller, Ferenc; Andersen, Jesper B. (Journal article; Peer reviewed, 2020-04)
      HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient ...

    • Androgen receptor as potential therapeutic target in metastatic endometrial cancer 

      Tangen, Ingvild Løberg; Onyango, Therese Bredholt; Kopperud, Reidun Kristin; Berg, Anna; Halle, Mari Kyllesø; Øyan, Anne Margrete; Werner, Henrica Maria Johanna; Trovik, Jone; Kalland, Karl-Henning; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2016-06-30)
      Purpose: The expression and involvement of estrogen (ER) and progesterone receptor (PR) is extensively studied in endometrial cancer. Androgen receptor (AR) is a hormone receptor less studied in female cancers, and we here ...

    • The ANeED study – ambroxol in new and early dementia with Lewy bodies (DLB): protocol for a phase IIa multicentre, randomised, double-blinded and placebo-controlled trial 

      Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Kirsebom, Bjørn-Eivind; Selnes, Per; Fløvig, John Christian Jøraholmen; Knapskog, Anne Brita; Skogseth, Ragnhild Eide; Hubbers, Jessica; Holst-Larsen, Elin; Rongve, Arvid (Journal article; Peer reviewed, 2023-05-26)
      Background: Currently, there are no disease-modifying pharmacological treatment options for dementia with Lewy bodies (DLB). The hallmark of DLB is pathological alpha-synuclein (aS) deposition. There are growing amounts ...