Browsing Faculty of Medicine by Title
Now showing items 3358-3377 of 8852
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A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target
(Peer reviewed; Journal article, 2019)Background and Aims GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) ... -
Functional studies of novel CYP21A2 mutations detected in Norwegian patients with congenital adrenal hyperplasia
(Peer reviewed; Journal article, 2014)In about 95% of cases, congenital adrenal hyperplasia (CAH) is caused by mutations in CYP21A2 gene encoding steroid 21-hydroxylase (21OH). Recently, we have reported four novel CYP21A2 variants in the Norwegian population ... -
Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia
(Peer reviewed; Journal article, 2014-06-03)Congenital tyrosine hydroxylase deficiency (THD) is found in autosomal-recessive Dopa-responsive dystonia and related neurological syndromes. The clinical manifestations of THD are variable, ranging from early-onset lethal ... -
Functional toll-like receptors (TLRs) are expressed by a majority of primary human acute myeloid leukemia cells and inducibility of the TLR signaling pathway is associatedwith a more favorable phenotype
(Peer reviewed; Journal article, 2019-07-11)Acute myeloid leukemia (AML) is a highlyheterogeneous disease withregardto biological characteristics and receptor expression. Toll-like receptors (TLRs) are upstream to the transcription factor NFκB and part of the innate ... -
Functionalization of Nanoparticles with Tyrosine Hydroxylase : Biotechnological and Therapeutic Implications
(Doctoral thesis, 2022-09-30)Tyrosine hydroxylase (TH) er et viktig enzym for nervesystemet, fordi det katalyserer det første steget i syntesen av dopamin, noradrenalin og adrenalin. Nivået på TH og dopamin synker hos Parkinsons pasienter pga. den ... -
Functionalizing Collagen Membranes with MSC-Conditioned Media Promotes Guided Bone Regeneration in Rat Calvarial Defects
(Journal article; Peer reviewed, 2023-02-28)Functionalizing biomaterials with conditioned media (CM) from mesenchymal stromal cells (MSC) is a promising strategy for enhancing the outcomes of guided bone regeneration (GBR). This study aimed to evaluate the bone ... -
Functions and Regulation of eukaryotic NAD kinase - an essential enzyme for NADP biosynthesis
(Doctoral thesis, 2008-02-15)NAD and NADP, both major carriers of cellular reducing equivalents, are of vital importance in diverse metabolic and signaling processes. Efficient maintenance and regulation of the reduction-oxidation status is therefore ... -
Fur glowing under ultraviolet: in situ analysis of porphyrin accumulation in the skin appendages of mammals
(Journal article; Peer reviewed, 2023)Examples of photoluminescence (PL) are being reported with increasing frequency in a wide range of organisms from diverse ecosystems. However, the chemical basis of this PL remains poorly defined, and our understanding of ... -
Further benefits by early start of HIV treatment in low income countries: Survival estimates of early versus deferred antiretroviral therapy
(Peer reviewed; Journal article, 2010-01-16)Background International HIV guidelines have recently shifted from a medium-late to an early-start treatment strategy. As a consequence, more people will be eligible to Highly Active Antiretroviral Therapy (HAART). We ... -
Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
(Peer reviewed; Journal article, 2019-05-20)Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like ... -
The Future Ethics of Artificial Intelligence in Medicine: Making Sense of Collaborative Models
(Journal article; Peer reviewed, 2022)This article examines the role of medical doctors, AI designers, and other stakeholders in making applied AI and machine learning ethically acceptable on the general premises of shared decision-making in medicine. Recent ... -
Fysisk aktivitet og astma blant barn og ungdommer i Bergen – RHINESSA-studien
(Master thesis, 2020-06-19)En stor andel av barn og unge i Norge har den kroniske lungesykdommen astma og behandles med astmamedikamenter for dette. Samtidig viser rapporten «Kartlegging av fysisk aktivitet, sedat tid og fysisk form blant barn og ... -
Fytokjemisk undersøkelse av Spansk kjørvel Myrrhis odorata (L.) Scop
(Master thesis, 2022-05-20) -
G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury
(Journal article; Peer reviewed, 2020)Background: G protein-gated inwardly rectifying potassium (GIRK) channels are involved in the regulation of neuronal excitability. Four GIRK subunits (GIRK1-4) are expressed in rat dorsal root ganglia (DRGs). Recently, we ... -
G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis
(Peer reviewed; Journal article, 2018-09-17)We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally ... -
GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production
(Journal article; Peer reviewed, 2020)Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neuromodulators. However, their biosynthetic routes and therapeutic potential are still being debated. This ... -
Gait characteristics in people with cognitive impairment - the relationship between step length and cadence
(Master thesis, 2016-05-13)Background: Approximately 70 000 people in Norway are suffering from some form of dementia. Gait and balance impairment in patients with Alzheimer's disease has been recognized for years. Reduced walking speed has been ... -
Gamified virtual reality exposure therapy for adolescents with public speaking anxiety: a four-armed randomized controlled trial
(Journal article; Peer reviewed, 2023)Objective: Public Speaking Anxiety is highly prevalent among adolescents. However, few interventions have been developed specifically for this group. This four-armed randomized trial addressed the following research questions ... -
Gamma Knife Radiosurgery does not alter the copy number aberration profile in sporadic vestibular schwannoma
(Journal article; Peer reviewed, 2020)Introduction: Ionizing radiation is a known etiologic factor in tumorigenesis and its role in inducing malignancy in the treatment of vestibular schwannoma has been debated. The purpose of this study was to identify a copy ...