Blar i Faculty of Medicine på tittel

Viser treff 4988-5007 av 8872

    • Liposomal formulation of an emetine analog in combination with daunorubicin for the treatment of acute myeloid leukemia 

      Bakke, Tuva Torblå (Master thesis, 2019-07-02)

    • A liposomal formulation of simvastatin and doxorubicin for improved cardioprotective and anti-cancer effect 

      Bjørnstad, Ronja; Reiten, Ingeborg Nerbø; Knudsen, Kaja Skålnes; Schjøtt, Jan Didrik; Herfindal, Lars (Journal article; Peer reviewed, 2022)
      Anthracyclines such as doxorubicin (Dox) are the preferred chemotherapeutics for several cancers. However, Dox-induced cardiotoxicity limits its therapeutic potential. Liposomal encapsulation of Dox has been used for ...

    • Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System 

      Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Journal article; Peer reviewed, 2021)
      Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ...

    • Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma 

      Lapitz, Ainhoa; Azkargorta, Mikel; Milkiewicz, Piotr; Olaizola, Paula; Zhuravleva, Ekaterina; Grimsrud, Marit Mæhle; Schramm, Christoph; Arbelaiz, Ander; O'Rourke, Colm J.; La Casta, Adelaida; Milkiewicz, Malgorzata; Pastor, Tania; Vesterhus, Mette Nåmdal; Jimenez-Agüero, Raul; Dill, Michael T.; Lamarca, Angela; Valle, Juan W.; Macias, Rocio I.R.; Izquierdo-Sanchez, Laura; Pérez Castaño, Ylenia; Caballero-Camino, Francisco Javier; Riaño, Ioana; Krawczyk, Marcin; Ibarra, Cesar; Bustamante, Javier; Nova-Camacho, Luiz M.; Falcon-Perez, Juan M.; Elortza, Felix; Perugorria, Maria J.; Andersen, Jesper B.; Bujanda, Luis; Karlsen, Tom Hemming; Folseraas, Trine; Rodrigues, Pedro M.; Banales, Jesus M. (Journal article; Peer reviewed, 2023)
      Background & Aims Cholangiocarcinoma (CCA), heterogeneous biliary tumours with dismal prognosis, lacks accurate early diagnostic methods especially important for individuals at high-risk (i.e. those with primary sclerosing ...

    • Listening to health workers: lessons from Eastern Uganda for strengthening the programme for the prevention of mother-to-child transmission of HIV 

      Rujumba, Joseph; Tumwine, James K.; Tylleskär, Thorkild; Neema, Stella; Heggenhougen, Harald K. (Peer reviewed; Journal article, 2012-01-05)
      Background: The implementation and utilization of programmes for the prevention of mother-to-child transmission (PMTCT) of HIV in most low income countries has been described as sub-optimal. As planners and service providers, ...

    • Listening to the polar oceans : Monitoring and mapping marine ecosystems using passive and active acoustics 

      Menze, Sebastian (Doctoral thesis, 2020-06-12)
      This interdisciplinary thesis uses active and passive acoustics to study the polar marine ecosystems. The polar oceans are some of the most remote, harshest and least well studied environments of the planet, and also the ...

    • Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders 

      Osete, Jordi Requena; Akkouh, Ibrahim; Reis de Assis, Denis; Szabo, Attila; Frei, Evgeniia; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)
      Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of action at the molecular level are still incompletely ...

    • Litteraturstudie: Implantatbehandling på pasienter med ektodermal dysplasi 

      Alizadeh, Lilly; Haukeland, Ida Marlene (Master thesis, 2022-01-31)
      Hensikt: Ektodermal dysplasi (ED) er en sjelden tilstand som kan føre til anomalier i strukturer av ektodermalt opphav, derunder tenner. Tilstanden kan også føre til funksjonelle og psykologiske problemer, og redusert ...

    • Live Attenuated Influenza Vaccine (LAIV) Immunization in Children and Adults: Lesson for Development of Universal Influenza Vaccine 

      Islam, Shahinul (Doctoral thesis, 2019-11-06)
      According to the WHO (World Health Organization), one billion peoples are infected annually of whom three to five millions become severely ill and 250-500 000 deaths worldwide (He, Wang et al. 2013) although the latest ...

    • Live attenuated influenza vaccine in children induces b-cell responses in tonsils 

      Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Pathirana, Rishi; Bredholt, Geir; Jul-Larsen, Åsne; Trieu, Mai Chi; Jalloh, Sarah Larteley Lartey; Montemoli, Emanuele; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016)
      Background. Tonsils play a key role in eliciting immune responses against respiratory pathogens. Little is known about how tonsils contribute to the local immune response after intranasal vaccination. Here, we uniquely ...

    • Live well, die well - an international cohort study on experiences, concerns and preferences of patients in the last phase of life: the research protocol of the iLIVE study 

      Yildiz, Berivan; Allan, Simon; Bakan, Misa; Barnestein-Fonseca, Pilar; Berger, Michael; Boughey, Mark; Christen, Andri; De Simone, Gustavo G; Egloff, Martina; Ellershaw, John; Elsten, Eline E. C. M.; Eychmüller, Steffen; Fischer, Claudia; Fürst, Carl Johan; Geijteman, Eric C. T.; Goldraij, Gabriel; Goossensen, Anne; Halfdanardottir, Svandis Iris; Haugen, Dagny Renata Faksvåg; Hedman, Christel; Hoppe, Tanja; Hughes, Rosemary; Iversen, Grethe Skorpen; Joshi, Melanie; Kodba-Ceh, Hana; Korfage, Ida J; Lunder, Urska; Lüthi, Nora; Martín-Roselló, Maria Luisa; Mason, Stephen; Mcglinchey, Tamsin; Montilla, Silvi; Rasmussen, Birgit H; Ruiz-Torreras, Inmaculada; Schelin, Maria E. C.; Sigurdardottir, Katrin Rut; Sigurdardottir, Valgerdur; Simon, Judith; Smeding, Ruthmarijke; Solvåg, Kjersti; Strupp, Julia; Tripodoro, Vilma; Van Der Kuy, Hugo M; Van Der Rijt, Carin C. D.; Van Zuylen, Lia; Veloso, Verónica I; Vibora-Martin, Eva; Voltz, Raymond; Zambrano, Sofia C; Van Der Heide, Agnes (Journal article; Peer reviewed, 2022)
      Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to ...

    • Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction 

      Jalloh, Sarah Larteley Lartey; Zhou, Fan; Brokstad, Karl Albert; Mohn, Kristin Greve-Isdahl; Slettevoll, Steffen Aleksander; Pathirana, Rishi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)
      Background: Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and ...

    • LIVE@Home.Path--innovating the clinical pathway for home-dwelling people with dementia and their caregivers: Study protocol for a mixed-method, stepped-wedge, randomized controlled trial 

      Husebø, Bettina; Allore, Heather; Achterberg, Wilco; Angeles, Renira Corinne; Ballard, Clive; Bruvik, Frøydis Kristine; Fæø, Stein Erik; Gedde, Marie H.; Hillestad, Eirin; Jacobsen, Frode F.; Kirkevold, Øyvind; Kjerstad, Egil; Kjome, Reidun Lisbet Skeide; Mannseth, Janne; Naik, Mala; Nouchi, Rui; Puaschitz, Nathalie; Samdal, Rune; Tranvåg, Oscar; Tzoulis, Charalampos; Vahia, Ipsit Vihang; Vislapuu, Maarja; Berge, Line Iden (Journal article; Peer reviewed, 2020)
      Background The global health challenge of dementia is exceptional in size, cost and impact. It is the only top ten cause of death that cannot be prevented, cured or substantially slowed, leaving disease management, caregiver ...

    • Lived experiences of frailty among home-dwelling older people and family caregivers 

      Søvde, Bente Egge (Doctoral thesis, 2023-09-01)
      Background: The aging population, increasing incidence of frailty with age and increased risk of reduced ability to carry out everyday activities reveal the challenges for the individuals living with frailty, their caregivers ...

    • Liver elastography in healthy children using three different systems - how many measurements are necessary? 

      Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland; Olafsdottir, Edda Jonina; Gilja, Odd Helge; Vesterhus, Mette (Journal article; Peer reviewed, 2020-12-21)
      Purpose Liver elastography is increasingly being applied in screening for and follow-up of pediatric liver disease, and has been shown to correlate well with fibrosis staging through liver biopsy. Because time is of the ...

    • Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems 

      Mjelle, Anders Batman; Fossdal, Guri; Gilja, Odd Helge; Vesterhus, Mette (Journal article; Peer reviewed, 2020)
      The aim of the study described here was to characterize three different liver elastography methods in primary sclerosing cholangitis (PSC) patients, for the first time exploring 2-D shear wave elastography (2-D-SWE) in PSC ...

    • Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes 

      Jain, Ruchi; Özgümüs, Türküler; Jensen, Troels Mygind; du Plessis, Elsa; Keindl, Magdalena; Møller, Cathrine Laustrup; Falhammar, Henrik; Nyström, Thomas; Catrina, Sergiu-Bogdan; Jörneskog, Gun; Jessen, Leon Eyrich; Forsblom, Carol; Haukka, Jani K.; Groop, Per-Henrik; Rossing, Peter; Groop, Leif; Eliasson, Mats; Eliasson, Björn; Brismar, Kerstin; Al-Majdoub, Mahmoud; Nilsson, Peter M.; Taskinen, Marja-Riitta; Ferrannini, Ele; Spégel, Peter; Berg, Tore Julsrud; Lyssenko, Valeriya (Journal article; Peer reviewed, 2020)
      Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma ...

    • Liver X receptors induce antiproliferative effects in basal-like breast cancer 

      Haugen, Mads; von der Lippe Gythfeldt, Hedda; Egeland, Eivind Valen; Svartdal Normann, Lisa; Pandya, Abhilash D.; Vedin, Lise-Lotte; Juell, Siri; Tenstad, Ellen; Øy, Geir Frode; Kristian, Alexandr; Marangoni, Elisabetta; Sørlie, Therese; Steffensen, Knut Rune; Mælandsmo, Gunhild Mari; Engebråten, Olav (Journal article; Peer reviewed, 2023)
      Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of ...

    • The liver-first approach for synchronous colorectal liver metastases: A systematic review and meta-analysis of completion rates and effects on survival 

      Zeyara, Adam; Torén, William; Søreide, Kjetil; Andersson, Roland (Journal article; Peer reviewed, 2021)
      Background: Patients presenting with synchronous colorectal liver metastases are increasingly being considered for a curative treatment, and the liver-first approach is gaining popularity in this context. However, little ...

    • The liver-heart axis in patients with severe obesity: the association between liver fibrosis and chronic myocardial injury may be explained by shared risk factors of cardiovascular disease 

      Young, Juliet; Seeberg, Kathrine; Aakre, Kristin Moberg; Borgeraas, Heidi; Nordstrand, Njord; Wisløff, Torbjørn; Hjelmesæth, Jøran Sture; Omland, Torbjørn; Hertel, Jens Kristoffer (Journal article; Peer reviewed, 2024)
      Background: Severe obesity is associated with increased risk of non-alcoholic fatty liver disease and cardiovascular disease. We hypothesized that liver fibrosis as quantified by the Enhanced Liver Fibrosis (ELF) test would ...