Blar i Faculty of Medicine på tittel
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Lipogenic effects of antipsychotic drugs in cultured cells and in rat
(Doctoral thesis, 2007-05-10)The etiology of the serious psychiatric disorder schizophrenia is unknown. Epidemiological studies indicate a high heritability with a complex pattern of transmission. Moreover, structural and genetic findings indicate ... -
Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4–dependent pathway and limits sensitivity to fluid therapy in mice
(Journal article; Peer reviewed, 2019-12-16)Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the ... -
Liposomal formulation of an emetine analog in combination with daunorubicin for the treatment of acute myeloid leukemia
(Master thesis, 2019-07-02) -
A liposomal formulation of simvastatin and doxorubicin for improved cardioprotective and anti-cancer effect
(Journal article; Peer reviewed, 2022)Anthracyclines such as doxorubicin (Dox) are the preferred chemotherapeutics for several cancers. However, Dox-induced cardiotoxicity limits its therapeutic potential. Liposomal encapsulation of Dox has been used for ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
(Journal article; Peer reviewed, 2021)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma
(Journal article; Peer reviewed, 2023)Background & Aims Cholangiocarcinoma (CCA), heterogeneous biliary tumours with dismal prognosis, lacks accurate early diagnostic methods especially important for individuals at high-risk (i.e. those with primary sclerosing ... -
Listening to health workers: lessons from Eastern Uganda for strengthening the programme for the prevention of mother-to-child transmission of HIV
(Peer reviewed; Journal article, 2012-01-05)Background: The implementation and utilization of programmes for the prevention of mother-to-child transmission (PMTCT) of HIV in most low income countries has been described as sub-optimal. As planners and service providers, ... -
Listening to the polar oceans : Monitoring and mapping marine ecosystems using passive and active acoustics
(Doctoral thesis, 2020-06-12)This interdisciplinary thesis uses active and passive acoustics to study the polar marine ecosystems. The polar oceans are some of the most remote, harshest and least well studied environments of the planet, and also the ... -
Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders
(Journal article; Peer reviewed, 2021)Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of action at the molecular level are still incompletely ... -
Litteraturstudie: Implantatbehandling på pasienter med ektodermal dysplasi
(Master thesis, 2022-01-31)Hensikt: Ektodermal dysplasi (ED) er en sjelden tilstand som kan føre til anomalier i strukturer av ektodermalt opphav, derunder tenner. Tilstanden kan også føre til funksjonelle og psykologiske problemer, og redusert ... -
Live Attenuated Influenza Vaccine (LAIV) Immunization in Children and Adults: Lesson for Development of Universal Influenza Vaccine
(Doctoral thesis, 2019-11-06)According to the WHO (World Health Organization), one billion peoples are infected annually of whom three to five millions become severely ill and 250-500 000 deaths worldwide (He, Wang et al. 2013) although the latest ... -
Live attenuated influenza vaccine in children induces b-cell responses in tonsils
(Peer reviewed; Journal article, 2016)Background. Tonsils play a key role in eliciting immune responses against respiratory pathogens. Little is known about how tonsils contribute to the local immune response after intranasal vaccination. Here, we uniquely ... -
Live well, die well - an international cohort study on experiences, concerns and preferences of patients in the last phase of life: the research protocol of the iLIVE study
(Journal article; Peer reviewed, 2022)Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to ... -
Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction
(Journal article; Peer reviewed, 2020)Background: Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and ... -
LIVE@Home.Path--innovating the clinical pathway for home-dwelling people with dementia and their caregivers: Study protocol for a mixed-method, stepped-wedge, randomized controlled trial
(Journal article; Peer reviewed, 2020)Background The global health challenge of dementia is exceptional in size, cost and impact. It is the only top ten cause of death that cannot be prevented, cured or substantially slowed, leaving disease management, caregiver ... -
Lived experiences of frailty among home-dwelling older people and family caregivers
(Doctoral thesis, 2023-09-01)Background: The aging population, increasing incidence of frailty with age and increased risk of reduced ability to carry out everyday activities reveal the challenges for the individuals living with frailty, their caregivers ... -
Liver elastography in healthy children using three different systems - how many measurements are necessary?
(Journal article; Peer reviewed, 2020-12-21)Purpose Liver elastography is increasingly being applied in screening for and follow-up of pediatric liver disease, and has been shown to correlate well with fibrosis staging through liver biopsy. Because time is of the ... -
Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems
(Journal article; Peer reviewed, 2020)The aim of the study described here was to characterize three different liver elastography methods in primary sclerosing cholangitis (PSC) patients, for the first time exploring 2-D shear wave elastography (2-D-SWE) in PSC ... -
Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes
(Journal article; Peer reviewed, 2020)Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma ... -
Liver X receptors induce antiproliferative effects in basal-like breast cancer
(Journal article; Peer reviewed, 2023)Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of ...