Blar i Faculty of Medicine på tittel

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    • A Mouse Model for Slowly Progressive Primary Tuberculosis 

      Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Journal article, 1999-08)
      The progression from primary Mycobacterium tuberculosis infection to disease is usually slow in humans. The aim of this study was to develop and characterize a mouse model for slowly progressive primary tuberculosis, using ...

    • Movement Aberrations in Patients with Long Lasting Subacromial Impingement Syndrome 

      Berg, Valborg Kristine (Master thesis, 2014-12-11)
      Background: Little research has been done to investigate possible movement aberrations in patients with long-lasting (> 12 weeks) shoulder impingement syndrome (SIS). Focus so far has mainly been on possible somatic ...

    • Movement quality evaluation and its correlation with recommended functional measures in hip osteoarthritis 

      Olsen, Aarid Liland; Magnussen, Liv Heide; Skjærven, Liv Karin Helvik; Assmus, Jörg; Sundal, Mary Anne; Ostelo, Raymond W.; Strand, Liv Inger (Journal article; Peer reviewed, 2020)
      Objective Hip osteoarthritis may cause compensational movement strategies that require extra physical and mental effort. Such aberrant functioning can be captured in movement quality evaluation. The objective of this study ...

    • Movement quality within a physiotherapy perspective years after scoliosis surgery 

      Moe-Nilssen, Nora (Master thesis, 2016-06-16)

    • Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial 

      Kreitman, Robert J.; Dearden, Claire; Zinzani, Pier Luigi; Delgado, Julio; Robak, Tadeusz; le Coutre, Philipp; Gjertsen, Bjørn Tore; Troussard, Xavier; Roboz, Gail J.; Karlin, Lionel; Gladstone, Douglas E.; Kuptsova-Clarkson, Nataliya; Liu, Shiyao; Patel, Priti; Rotolo, Federico; Mitry, Emmanuel; Pastan, Ira; Giles, Frank (Journal article; Peer reviewed, 2021)
      Background Moxetumomab pasudotox is a recombinant CD22-targeting immunotoxin. Here, we present the long-term follow-up analysis of the pivotal, multicenter, open-label trial (NCT01829711) of moxetumomab pasudotox in ...

    • MPT64 antigen detection test improves diagnosis of pediatric extrapulmonary tuberculosis in Mbeya, Tanzania 

      Grønningen, Erlend; Nanyaro, Marywinnie; Sviland, Lisbet; Ngadaya, Esther; Muller, William; Torres, Lisete; Mfinanga, Sayoki; Mustafa, Tehmina (Journal article; Peer reviewed, 2021)
      Pediatric extrapulmonary tuberculosis (EPTB) is a diagnostic challenge. A new immunochemistry based MPT64 antigen detection test has shown improved sensitivity compared to current laboratory tests. The aim of this study ...

    • MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar 

      Jørstad, Melissa Davidsen; Marijani, Msafiri; Dyrhol-Riise, Anne Ma; Sviland, Lisbeth; Mustafa, Tehmina (Peer reviewed; Journal article, 2018-05-09)
      Background: Extrapulmonary tuberculosis (EPTB) is a diagnostic challenge. An immunochemistry-based MPT64 antigen detection test (MPT64 test) has reported higher sensitivity in the diagnosis of EPTB compared with conventional ...

    • MRI adipose tissue segmentation and quantification in R (RAdipoSeg) 

      Haugen, Christine; Lysne, Vegard; Haldorsen, Ingfrid S.; Tjora, Erling; Gudbrandsen, Oddrun Anita; Sagen, Jørn Vegard; Dankel, Simon N; Mellgren, Gunnar (Journal article; Peer reviewed, 2022-10-08)
      Background: Excess adipose tissue is associated with increased cardiovascular and metabolic risk, but the volume of visceral and subcutaneous adipose tissue poses different metabolic risks. MRI with fat suppression can be ...

    • MRI characterisation of adult onset alpha-methylacyl-coA racemase deficiency diagnosed by exome sequencing 

      Haugarvoll, Kristoffer; Johansson, Stefan; Tzoulis, Charalampos; Haukanes, Bjørn Ivar; Bredrup, Cecilie; Neckelmann, Gesche; Boman, Helge; Knappskog, Per; Bindoff, Laurence (Peer reviewed; Journal article, 2013-01-03)
      Background: Correct diagnosis is pivotal to understand and treat neurological disease. Herein, we report the diagnostic work-up utilizing exome sequencing and the characterization of clinical features and brain MRI in two ...

    • MRI findings in candidates for lumbar disc prosthesis: reliability and relationship to disability and pain 

      Berg, Linda (Doctoral thesis, 2014-11-21)
      Background and objective: In candidates for lumbar disc prosthesis, limited reliability data exist for magnetic resonance imaging (MRI) findings relevant to planning of treatment and to evaluation of outcome after treatment. ...

    • MRI-assessed tumor-free distance to serosa predicts deep myometrial invasion and poor outcome in endometrial cancer 

      Dybvik, Julie Andrea; Fasmer, Kristine Eldevik; Ytre-Hauge, Sigmund; Husby, Jenny Hild Aase; Salvesen, Øyvind; Stefansson, Ingunn Marie; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2022)
      Objectives To explore the diagnostic accuracy of preoperative magnetic resonance imaging (MRI)-derived tumor measurements for the prediction of histopathological deep (≥ 50%) myometrial invasion (pDMI) and prognostication ...

    • An mri-based radiomic prognostic index predicts poor outcome and specific genetic alterations in endometrial cancer 

      Jacob, Havjin; Dybvik, Julie Andrea; Ytre-Hauge, Sigmund; Fasmer, Kristine E.; Høivik, Erling Andre; Trovik, Jone; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Integrative tumor characterization linking radiomic profiles to corresponding gene expression profiles has the potential to identify specific genetic alterations based on non-invasive radiomic profiling in cancer. The aim ...

    • MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes 

      Klæstad, Elise; Opdahl, Signe; Engstrøm, Monica J; Ytterhus, Borgny; Wik, Elisabeth; Bofin, Anna Mary; Valla, Marit (Journal article; Peer reviewed, 2020-01-16)
      Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 copy ...

    • mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis 

      Yu, Xinhua; Koczan, Dirk; Sulonen, Anna-Maija; Akkad, Denis A.; Kroner, Antje; Comabella, Manuel; Costa, Gianna; Corongiu, Daniela; Goertsches, Robert; Camina-Tato, Montserrat; Thiese, Hans-Juergen; Nyland, Harald Inge; Mørk, Sverre; Montalban, Xavier; Rieckmann, Peter; Marrosu, Maria G.; Myhr, Kjell-Morten; Epplen, Joerg T.; Saarela, Sanna; Ibrahim, Saleh M. (Peer reviewed; Journal article, 2008-02-13)
      Background: Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. Methods and Findings: In order to investigate the role ...

    • MtDNA sequence features associated with 'selfish genomes' predict tissue-specific segregation and reversion 

      Røyrvik, Ellen Christine; Johnston, Iain (Journal article; Peer reviewed, 2020)
      Mitochondrial DNA (mtDNA) encodes cellular machinery vital for cell and organism survival. Mutations, genetic manipulation, and gene therapies may produce cells where different types of mtDNA coexist in admixed populations. ...

    • MTHFD1 and relevant biomarkers in cardiovascular disease: Observational studies in patients with suspected stable angina pectoris in Norway 

      Ding, Yunpeng (Doctoral thesis, 2017-03-24)
      Background: As the leading cause of death globally, cardiovascular disease (CVD) is a major public health burden. Epidemiological and experimental studies consistently demonstrate an association between elevated total ...

    • The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants 

      El Jellas, Khadija; Johansson, Bente Berg; Fjeld, Karianne; Antonopoulos, Aristotelis; Immervoll, Heike; Choi, Man Hung; Hoem, Dag; Lowe, Mark E.; Lombardo, Dominique; Njølstad, Pål Rasmus; Dell, Anne; Mas, Eric; Haslam, Stuart M.; Molven, Anders (Peer reviewed; Journal article, 2018)
      Carboxyl-ester lipase (CEL) is a pancreatic fat-digesting enzyme associated with human disease. Rare mutations in the CEL gene cause a syndrome of pancreatic exocrine and endocrine dysfunction denoted MODY8, whereas a ...

    • Mulige interaksjoner mellom tyrosin kinase reseptoren Axl, metabolisme og proliferasjon i brystkreftceller (MDA-MB-231) 

      Bergslien, Ingunn (Master thesis, 2009-05-19)
      Metabolismen i kreftceller er assosiert med økt aerob glykolyse, et fenomen omtalt som Warburg effekten. Den forhøyede glykolytiske raten utgjør en av de større forskjellene, som skiller normale celler fra kreftceller, og ...

    • Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk 

      Shrine, Nick; Izquierdo, Abril G.; Chen, Jing; Packer, Richard; Hall, Robert J.; Guyatt, Anna L.; Batini, Chiara; Thompson, Rebecca J.; Pavuluri, Chandan; Malik, Vidhi; Hobbs, Brian D.; Moll, Matthew; Kim, Wonji; Tal-Singer, Ruth; Bakke, Per S.; Fawcett, Katherine A.; John, Catherine; Coley, Kayesha; Piga, Noemi Nicole; Pozarickij, Alfred; Lin, Kuang; Millwood, Iona Y.; Chen, Zhengming; Li, Liming; Wijnant, Sara R A; Lahousse, Lies; Brusselle, Guy; Uitterlinden, Andre G.; Manichaikul, Ani; Oelsner, Elizabeth C.; Rich, Stephen S.; Barr, R Graham; Kerr, Shona M.; Vitart, Veronique; Brown, Michael R.; Wielscher, Matthias; Imboden, Medea; Jeong, Ayoung; Bartz, Traci M.; Gharib, Sina A.; Flexeder, Claudia; Karrasch, Stefan; Gieger, Christian; Peters, Annette; Stubbe, Beate; Hu, Xiaowei; Ortega, Victor E.; Meyers, Deborah A.; Bleecker, Eugene R.; Gabriel, Stacey B.; Gupta, Namrata; Smith, Albert Vernon; Luan, Jian'an; Zhao, Jing-Hua; Hansen, Ailin Falkmo; Langhammer, Arnulf; Willer, Cristen; Bhatta, Laxmi; Porteous, David; Smith, Blair H.; Campbell, Archie; Sofer, Tamar; Lee, Jiwon; Daviglus, Martha L.; Yu, Bing; Lim, Elise; Xu, Hanfei; O'Connor, George T.; Thareja, Gaurav; Albagha, Omar M E; Suhre, Karsten; Granell, Raquel; Faquih, Tariq O.; Hiemstra, Pieter S.; Slats, Annelies M.; Mullin, Benjamin H.; Hui, Jennie; James, Alan; Beilby, John; Patasova, Karina; Hysi, Pirro; Koskela, Jukka T.; Wyss, Annah B.; Jin, Jianping; Sikdar, Sinjini; Lee, Mikyeong; May-Wilson, Sebastian; Pirastu, Nicola; Kentistou, Katherine A.; Joshi, Peter K.; Timmers, Paul R H J; Williams, Alexander T.; Free, Robert C.; Wang, Xueyang; Morrison, John L.; Gilliland, Frank D.; Chen, Zhanghua; Wang, Carol A.; Foong, Rachel E.; Harris, Sarah E.; Taylor, Adele; Redmond, Paul; Cook, James P.; Mahajan, Anubha; Lind, Lars; Palviainen, Teemu; Lehtimäki, Terho; Raitakari, Olli T.; Kaprio, Jaakko; Rantanen, Taina; Pietiläinen, Kirsi H.; Cox, Simon R.; Pennell, Craig E.; Hall, Graham L.; Gauderman, W James; Brightling, Chris; Wilson, James F.; Vasankari, Tuula; Laitinen, Tarja; Salomaa, Veikko; Mook-Kanamori, Dennis O.; Timpson, Nicholas J.; Zeggini, Eleftheria; Dupuis, Josée; Hayward, Caroline; Brumpton, Ben Michael; Langenberg, Claudia; Weiss, Stefan; Homuth, Georg; Schmidt, Carsten Oliver; Probst-Hensch, Nicole; Jarvelin, Marjo-Riitta; Morrison, Alanna C.; Polasek, Ozren; Rudan, Igor; Lee, Joo-Hyeon; Sayers, Ian; Rawlins, Emma L.; Dudbridge, Frank; Silverman, Edwin K.; Strachan, David P.; Walters, Robin G.; Morris, Andrew P.; London, Stephanie J.; Cho, Michael H.; Wain, Louise V.; Hall, Ian P.; Tobin, Martin D. (Journal article; Peer reviewed, 2023)
      Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 ...

    • A multi-layer perceptron network for perfusion parameter estimation in DCE-MRI studies of the healthy kidney 

      Klepaczko, Artur; Strzelecki, Michał; Kociołek, Marcin; Eikefjord, Eli Bjøvad; Lundervold, Arvid (Journal article; Peer reviewed, 2020)
      Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an imaging technique which helps in visualizing and quantifying perfusion—one of the most important indicators of an organ’s state. This paper ...