Blar i Faculty of Medicine på tittel
Viser treff 8405-8424 av 8852
-
Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK
(Peer reviewed; Journal article, 2014-11-20)BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ... -
Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial
(Peer reviewed; Journal article, 2019)Background: Digital breast tomosynthesis is an advancement of mammography, and has the potential to overcome limitations of standard digital mammography. This study aimed to compare first-generation digital breast ... -
Two-year changes in gait variability in community-living older adults
(Peer reviewed; Journal article, 2019-06-07)Background: Increases in stride-to-stride fluctuations (gait variability) are common among older adults, but little is known about the natural progression of gait variability with increasing age. Research question: Does ... -
A two-year longitudinal follow-up of cognitive performance assessed by BICAMS in newly diagnosed patients with MS
(Journal article; Peer reviewed, 2020)Background: Cognitive impairment is common in patients with multiple sclerosis (MS) and may occur at any stage and with any subtype of the disease. Screening and monitoring of cognitive function should therefore be implemented ... -
Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy
(Peer reviewed; Journal article, 2010-12-03)Background To examine the expression of type 1 plasminogen inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC), and its possible association with microvessel density (MVD), the expression of thrombospondin-1 ... -
Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets
(Journal article; Peer reviewed, 2022-08-03)Recent evidence suggests that circadian clocks ensure temporal orchestration of lipid homeostasis and play a role in pathophysiology of metabolic diseases in humans, including type 2 diabetes (T2D). Nevertheless, circadian ... -
Type 2 diabetes genes : present status and data from Norwegian studies
(Peer reviewed; Journal article, 2013)The worldwide rise in prevalence of type 2 diabetes has led to an intense search for the genetic risk factors of this disease. In type 2 diabetes and other complex disorders, multiple genetic and environmental factors, as ... -
Type 2 diabetes in general practice in Norway - status, time trends, and quality of care
(Doctoral thesis, 2020-02-14)Background and objectives: People with type 2 diabetes have increased risk of vascular complications and premature death. Good glycaemic control and adequate management of cardiovascular risk factors can reduce the risk ... -
Type 2 diabetes in general practice in Norway 2005-2014: moderate improvements in risk factor control, but still major gaps in complication screening
(Peer reviewed; Journal article, 2017)Objective: To assess the status of type 2 diabetes care in general practice and changes in the quality of care between 2005 and 2014, and to identify areas of diabetes care requiring improvement. Research design and methods: ... -
Type 2-diabetes i fastlegepraksis – en fokusgruppestudie
(Journal article; Peer reviewed, 2021)BAKGRUNN Nasjonal diabetesplan 2017–21 har iverksatt tiltak for å bedre diagnostisering og oppfølging av personer med type 2-diabetes i primærhelsetjenesten. Formålet med denne studien var å undersøke norske fastlegers ... -
Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
(Journal article; Peer reviewed, 2023)Objectives: To systematically review the literature for assay methods that aim to evaluate type I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods: Three databases were searched for ... -
Typologies in GPs’ referral practice
(Peer reviewed; Journal article, 2016-07-18)Background: GPs’ individual decisions to refer and the various ways of working when they refer are important determinants of secondary care use. The objective of this study was to explore and describe potential characteristics ... -
Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease
(Peer reviewed; Journal article, 2017)Introduction: The ancient and ubiquitous monoamine signalling molecules serotonin, dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions. The aromatic amino acid hydroxylases tyrosine ... -
Tyrosine kinase inhibitors and interferon‐α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines (
(Journal article; Peer reviewed, 2020)Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where mechanisms of inter‐leukemic communication and cell‐to‐cell interactions are proposed to be important for optimal therapy response. Tunneling ... -
Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis
(Peer reviewed; Journal article, 2020)Hereditary tyrosinemia Type 1 (HT‐1) is a rare metabolic disease where the enzyme catalyzing the final step of tyrosine breakdown is defect, leading to accumulation of toxic metabolites. Nitisinone inhibits the degradation ... -
U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells
(Peer reviewed; Journal article, 2014-08)It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination ... -
UCP1 induction during recruitment of Brown Adipocytes in White Adipose tissue is dependent on Cyclooxygenase activity
(Peer reviewed; Journal article, 2010-06-30)Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and ... -
UGT1A4 og UGT2B15 enkeltnukleotidpolymorfismer. Etablering av real time PCR metoder og betydning for tamoxifen metabolisme
(Master thesis, 2008-06-02)Brystkreft er den vanligste kreftformen blant kvinner i Norge og adjuvant tamoxifenbehandling er vist å øke tilbakefallsfri og total overlevelse. Den interinidividuelle varaiasjonen i effekt og bivirkninger av tamoxifen ... -
Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA
(Journal article; Peer reviewed, 2022)While DNA methylation is established as a major regulator of gene expression in the nucleus, the existence of mitochondrial DNA (mtDNA) methylation remains controversial. Here, we characterized the mtDNA methylation landscape ... -
Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation
(Journal article; Peer reviewed, 2022)Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ...