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The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection
(Peer reviewed; Journal article, 2016-10-24)Background: Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. ... -
Creating the Simulated Patient Through Dialogue: An Approach Based on Bakhtin’s Dialogical Thinking
(Peer reviewed; Journal article, 2010)Simulated patients (SP) are being used in medical communication training worldwide. The character of an SP will be trained in advance. However, the dialogue with the student is never fully predictable. The aim of this study ... -
Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease
(Peer reviewed; Journal article, 2019-09-09)Purpose: We hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary artery ... -
The creation of meaning : intensive care nurses’ experiences of conducting nurse-led follow-up on intensive care units
(Peer reviewed; Journal article, 2019-08)Objective: To explore and describe the experiences of Norwegian intensive care unit nurses providing nurse-led follow-up to patients and their families. Design and methods: The study had a qualitative design with a ... -
CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons
(Peer reviewed; Journal article, 2020)BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming ... -
Criteria for the procedural fairness of health financing decisions: a scoping review
(Journal article; Peer reviewed, 2023)Due to constraints on institutional capacity and financial resources, the road to universal health coverage (UHC) involves difficult policy choices. To assist with these choices, scholars and policy makers have done extensive ... -
Critical appraisal and meta-analysis of biological variation estimates for kidney related analytes
(Journal article; Peer reviewed, 2020)Objective: Kidney markers are some of the most frequently used laboratory tests in patient care, and correct clinical decision making depends upon knowledge and correct application of biological variation (BV) data. The ... -
A critical appraisal of the evidence for using cardiotocography plus ECG ST interval analysis for fetal surveillance in labor. Part I: The randomized controlled trials
(Peer reviewed; Journal article, 2014-06)We reappraised the five randomized controlled trials that compared cardiotocography plus ECG ST interval analysis (CTG+ST) vs. cardiotocography. The numbers enrolled ranged from 5681 (Dutch randomized controlled trial) to ... -
A critical appraisal of the evidence for using cardiotocography plus ECG ST interval analysis for fetal surveillance in labor. Part II: The meta-analyses
(Peer reviewed; Journal article, 2014-06)We appraised the methodology, execution and quality of the five published meta-analyses that are based on the five randomized controlled trials which compared cardiotocography (CTG)+ST analysis to cardiotocography. The ... -
A critical assessment of the WHO responsiveness tool: lessons from voluntary HIV testing and counselling services in Kenya
(Peer reviewed; Journal article, 2009-12-22)Background: Health, fair financing and responsiveness to the user's needs and expectations are seen as the essential objectives of health systems. Efforts have been made to conceptualise and measure responsiveness as a ... -
Critical evaluation of the appetite test for children with severe acute malnutrition
(Peer reviewed; Journal article, 2020)OBJECTIVES: The appetite test is used to risk-stratify for children with severe acute malnutrition (SAM) in in-patient or out-patient care. The test is recommended in guidelines despite lack of evidence. We evaluated its ... -
A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation
(Peer reviewed; Journal article, 2014-02-04)Antipsychotic drugs have thus far focused on dopaminergic antagonism at the D2 receptors, as counteracting the hyperdopaminergia in nigrostriatal and mesolimbic projections has been considered mandatory for the antipsychotic ... -
CRMP5 Antibodies—Diagnostic Challenges
(Journal article; Peer reviewed, 2021-09-22)CRMP5-associated paraneoplastic neurological syndromes (PNS) are rare, and only few studies describe larger cohorts of patients with CRMP5 antibodies. We have included 24 patients with CRMP5 antibodies and compared clinical ... -
Cross talk between cytokine and hyperthermia-induced pathways: identification of different subsets of NF-κB-dependent genes regulated by TNFα and heat shock
(Peer reviewed; Journal article, 2015-05-06)Heat shock inhibits NF-κB signaling, yet the knowledge about its influence on the regulation of NF-κB-dependent genes is limited. Using genomic approaches, i.e., expression microarrays and ChIP-Seq, we aimed to establish ... -
“Cross-cultural translation, validity and reliability of the Norwegian Version of the Neurophysiology of Pain Questionnaire”
(Master thesis, 2020-11-13)Bakgrunn: The Neurophysiology of Pain Questionnaire (NPQ) ble utviklet som et verktøy for å vurdere hvordan individer konseptualiserer sin egen smerteopplevelse. Spørreskjemaet kan bli brukt for å evaluere om helsepersonell ... -
Cross-cultural Validation of the Norwegian Version of the Banff Patellofemoral Instability Instrument 2.0
(Journal article; Peer reviewed, 2023)Background: The Banff Patellofemoral Instability Instrument (BPII) 2.0 is a disease-specific quality of life questionnaire for patients with patellofemoral instability. While good psychometric properties have been demonstrated, ... -
Cross-fitted instrument: A blueprint for one-sample Mendelian randomization
(Journal article; Peer reviewed, 2022-08-29)Bias from weak instruments may undermine the ability to estimate causal effects in instrumental variable regression (IVR). We present here a new approach to handling weak instrument bias through the application of a new ... -
Cross-reactivity of the CEDIA buprenorphine assay in drugs-of-abuse screening: influence of dose and metabolites of opioids
(Peer reviewed; Journal article, 2015-10-28)Purpose: The cloned enzyme donor immunoassay (CEDIA) for buprenorphine is applied for both urine drugs-of-abuse screening and compliance monitoring. Sensitivity, specificity, and optimal cutoff of this assay have differed ... -
A cross-sectional analysis of the association between health related quality of life and bodyweight changes
(Master thesis, 2013-01-05)Introduction Bodyweight outside the normal range is commonly associated with reduced health related quality of life (HRQL), while physical activity has shown to improve HRQL. Few studies have investigated the effect of ...