Browsing Faculty of Medicine by Title

Now showing items 1811-1830 of 8830

    • Decision-making processes for essential packages of health services: Experience from six countries 

      Baltussen, Rob; Omar, Omar Mwalim; Blanchet, Karl; Carballo, Manuel; Eregata, Getachew Teshome; Hailu, Alemayehu; Huda, Maryam; Jama, Mohamed; Johansson, Kjell Arne; Reynolds, Teri; Raza, Wajeeha; Mallender, Jacque; Majdzadeh, Reza (Journal article; Peer reviewed, 2023)
      Many countries around the world strive for universal health coverage, and an essential packages of health services (EPHS) is a central policy instrument for countries to achieve this. It defines the coverage of services ...

    • Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models 

      Buociková, Verona; Longhin, Eleonora Marta; Pilalis, Eleftherios; Mastrokalou, Chara; Miklíková, Svetlana; Cihova, Marina; Poturnayova, Alexandra; Mackova, Katarina; Bábelová, Andrea; Trnkova, Lenka; El Yamani, Naouale; Zheng, Congying; Rios-Mondragon, Ivan; Labudova, Martina; Csaderova, Lucia; Kuracinova, Kristina Mikus; Makovicky, Peter; Kučerová, Lucia; Matuskova, Miroslava; Cimpan, Mihaela-Roxana; Dusinska, Maria; Babal, Pavel; Chatziioannou, Aristotelis; Gábelová, Alena; Rundén-Pran, Elise; Smolkova, Bozena (Journal article; Peer reviewed, 2022)
      Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns and sensitize cancer ...

    • Decitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines; the impact of DCK overexpression 

      Buociková, Verona; Tyciakova, Sylvia; Pilalis, Eleftherios; Mastrokalou, Chara; Urbanova, Maria; Matuskova, Miroslava; Demkova, Lucia; Medova, Veronika; Longhin, Eleonora Marta; Rundén-Pran, Elise; Dusinska, Maria; Rios Mondragon, Ivan; Cimpan, Mihaela-Roxana; Gábelová, Alena; Soltysova, Andrea; Smolkova, Bozena; Chatziioannou, Aristotelis (Journal article; Peer reviewed, 2022)
      Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors. Although epigenome modulation provides a promising ...

    • Decline in HIV Prevalence among Young Women in Zambia: National-Level Estimates of Trends Mask Geographical and Socio-Demographic Differences 

      Kayeyi, Nkomba; Fylkesnes, Knut; Michelo, Charles Cheembo; Makasa, Mpundu; Sandøy, Ingvild Fossgard (Peer reviewed; Journal article, 2012-04-04)
      Background: A decline in HIV incidence has been reported in Zambia and a number of other sub-Saharan countries. The trend of HIV prevalence among young people is a good marker of HIV incidence. In this study, different ...

    • The decline of the impetigo epidemic caused by the epidemic European fusidic acid-resistant impetigo clone: an 11.5-year population-based incidence study from a community in Western Norway 

      Rørtveit, Sverre; Skutlaberg, Dag Harald; Langeland, Nina; Rørtveit, Guri (Peer reviewed; Journal article, 2014-12)
      Background: From around the year 2000, Northern Europe experienced a rise in impetigo caused by Staphylococcus aureus resistant to fusidic acid. A single clone of S. aureus was found to be the bacterial pathogen involved ...

    • Decoding cancer's camouflage: epithelialmesenchymal plasticity in resistance to immune checkpoint blockade 

      Lotsberg, Maria Lie; Rayford, Austin James; Thiery, Jean Paul; Bellaggia, Giuliana; Peters, Stacey D'Mello; Lorens, James; Chouaib, Salem; Terry, Stéphane; Engelsen, Agnete (Journal article, 2020)
      Epithelial-mesenchymal plasticity (EMP) of cancer cells contributes to cancer cell heterogeneity, and it is well established that EMP is a critical determinant of acquired resistance to cancer treatment modalities including ...

    • Decolonizing global health: A scoping review protocol 

      Amri, Michelle; Yang, Jinny; Barrett, Kathryn; Bump, Jesse Boardman (Journal article; Peer reviewed, 2023)
      Although there has been attention paid to decolonizing global health, there is no accepted understanding of the concept. Therefore, this protocol outlines the steps for a planned scoping review to assess the academic ...

    • Decolonizing health governance: A Uganda case study on the influence of political history on community participation 

      Mulumba, Moses; Ruano, Ana Lorena; Perehudoff, Katrina; Ooms, Gorik (Journal article; Peer reviewed, 2021)
      This paper presents a case study of how colonial legacies in Uganda have affected the shape and breadth of community participation in health system governance. Using Habermas’s theory of deliberative democracy and the right ...

    • Decompression alone versusdecompression with instrumental fusionthe NORDSTEN degenerativespondylolisthesis trial (NORDSTEN-DS); study protocol for a randomized controlled trial 

      Austevoll, Ivar Magne; Hermansen, Erland; Fagerland, Morten; Rekeland, Frode; Solberg, Tore; Storheim, Kjersti; Brox, Jens Ivar; Lønne, Greger; Indrekvam, Kari; Aaen, Jørn; Grundnes, Oliver; Hellum, Christian (Peer reviewed; Journal article, 2019-01-05)
      Background: Fusion in addition to decompression has become the standard treatment for lumbar spinal stenosis with degenerative spondylolisthesis (DS). The evidence for performing fusion among these patients is conflicting ...

    • Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis 

      Austevoll, Ivar Magne; Hermansen, Erland; Fagerland, Morten Wang; Storheim, Kjersti; Brox, Jens Ivar; Solberg, Tore; Rekeland, Frode; Franssen, Eric; Weber, Clemens; Brisby, Helena; Grundnes, Oliver; Algaard, Knut; Bøker, Tordis; Banitalebi, Hasan; Indrekvam, Kari; Hellum, Christian (Journal article; Peer reviewed, 2021)
      BACKGROUND In patients with lumbar spinal stenosis and degenerative spondylolisthesis, it is uncertain whether decompression surgery alone is noninferior to decompression with instrumented fusion. METHODS We conducted an ...

    • Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells 

      Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila; Djurovic, Srdjan (Journal article; Peer reviewed, 2020)
      Schizophrenia (SCZ) is a severe mental disorder with a high heritability. Although its pathophysiology is mainly unknown, dysregulated immune activation and inflammation have recently emerged as possible candidates in the ...

    • Decreased survival of medial pivot designs compared with cruciate-retaining designs in TKA without patellar resurfacing. 

      Øhrn, Frank-David; Gøthesen, Øystein; Lygre, Stein Håkon Låstad; Peng, Yi; Lian, Øystein Bjerkestrand; Lewis, Peter L; Furnes, Ove; Röhrl, Stephan Maximillian (Journal article; Peer reviewed, 2020)
      Background The medial pivot TKA design was introduced in the 1990s. These are fixed-bearing, medial-conforming implants with virtually no translation in the medial part of the knee, in contrast to the flat lateral part ...

    • Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays 

      Thunemann, Martin; Lu, Yichen; Liu, Xin; Kılıç, Kıvılcım; Desjardins, Michèle; Vandenberghe, Matthieu; Sadegh, Sanaz; Saisan, Payam A.; Cheng, Qun; Weldy, Kimberly L.; Lyu, Hongming; Djurovic, Srdjan; Andreassen, Ole Andreas; Dale, Anders; Devor, Anna; Kuzum, Duygu (Peer reviewed; Journal article, 2018-05-23)
      Recent advances in optical technologies such as multi-photon microscopy and optogenetics have revolutionized our ability to record and manipulate neuronal activity. Combining optical techniques with electrical recordings ...

    • Deep exploration of a CDKN1C mutation causing a mixture of Beckwith-Wiedemann and IMAGe syndromes revealed a novel transcript associated with developmental delay 

      Berland, Siren; Haukanes, Bjørn Ivar; Juliusson, Petur Benedikt; Houge, Gunnar (Journal article; Peer reviewed, 2022)
      Background: Loss-of-function mutations in CDKN1C cause overgrowth, that is, Beckwith-Wiedemann syndrome (BWS), while gain-of-function variants in the gene’s PCNA binding motif cause a growth-restricted condition called ...

    • Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2 

      Juliusson, Petur B.; Bruserud, Ingvild S.; Oehme, Ninnie Helen Bakken; Madsen, Andre; Forthun, Ingvild Halsør; Balthasar, Melissa Rajini; Viste, kristin; Jugessur, Astanand; Schell, Lawrence M.; Bjerknes, Robert; Roelants, Mathieu; Karen, Rosendahl (Journal article; Peer reviewed, 2023)
      Background The Bergen Growth Study 2 (BGS2) aims to characterise somatic and endocrine changes in healthy Norwegian children using a novel methodology. Subjects and methods A cross-sectional sample of 1285 children ...

    • Default-mode network functional connectivity is closely related to metabolic activity 

      Passow, Susanne; Specht, Karsten; Adamsen, Tom Christian; Biermann, Martin; Brekke, Njål; Craven, Alexander R.; Ersland, Lars; Grüner, Renate; Kleven-Madsen, Nina; Kvernenes, Ole Heine; Schwarzlmüller, Thomas; Olesen, Rasmus Aamand; Hugdahl, Kenneth (Peer reviewed; Journal article, 2015-06)
      Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ...

    • Defective i⁶A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA 

      Yarham, John W.; Lamichhane, Tek N.; Pyle, Angela; Mattijssen, Sandy; Baruffini, Enrico; Bruni, Francesco; Donnini, Claudia; Vassilev, Alex; He, Langping; Blakely, Emma L.; Griffin, Helen; Santibanez-Koref, Mauro; Bindoff, Laurence; Ferrero, Iliana; Chinnery, Patrick F.; McFarland, Robert; Maraia, Richard J.; Taylor, Robert W. (Peer reviewed; Journal article, 2014-06-05)
      Identifying the genetic basis for mitochondrial diseases is technically challenging given the size of the mitochondrial proteome and the heterogeneity of disease presentations. Using next-generation exome sequencing, we ...

    • Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease 

      Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos (Peer reviewed; Journal article, 2016-11-22)
      Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ...

    • Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia 

      St-Louis, Johanna L.; el Jellas, Khadija; Velasco, Kelly; Slipp, Brittany A.; Hu, Jiang; Helgeland, Geir; Steine, Solrun; De Jesus, Dario F.; Kulkarni, Rohit N.; Molven, Anders (Journal article; Peer reviewed, 2023)
      Congenital hyperinsulinism of infancy (CHI) can be caused by a deficiency of the ubiquitously expressed enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). To test the hypothesis that SCHAD-CHI arises from a specific ...

    • Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta 

      Gavasso, Sonia; Mosleth, Ellen Færgestad; Marøy, Tove Helene; Jørgensen, Katarina Mariann; Nakkestad, Hanne Linda; Gjertsen, Bjørn Tore; Myhr, Kjell-Morten; Vedeler, Christian A. (Peer reviewed; Journal article, 2014-02-19)
      Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ...