Blar i Faculty of Medicine på tittel
Viser treff 3042-3061 av 8826
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Expression of ESE-3 Isoforms in Immunogenic and Tolerogenic Human Monocyte-Derived Dendritic Cells
(Peer reviewed; Journal article, 2012-11-19)Dendritic cells (DC) are the only hematopoietic cells expressing the epithelial specific Ets transcription factor ESE-3. Here we analyzed presence and quantity of isoforms ESE-3a, ESE-3b and ESE-3j in various immunogenic ... -
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
(Molecular Cancer 5(47), Peer reviewed; Journal article, 2006-10-20)Background: The tumor suppressor gene p53 (TP53) controls numerous signaling pathways and is frequently mutated in human cancers. Novel p53 isoforms suggest alternative splicing as a regulatory feature of p53 activity. ... -
Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study
(Journal article, 2016-05-11)The aim of this study was to identify potential predictive biomarkers in 35 patients with metastatic melanoma treated with anti-angiogenic bevacizumab monotherapy in a clinical phase II study. The immunohistochemical ... -
Expression of L1CAM in curettage or high L1CAM level in preoperative blood samples predicts lymph node metastases and poor outcome in endometrial cancer patients
(Peer reviewed; Journal article, 2017-09)Background: Several studies have identified L1 cell adhesion molecule (L1CAM) as a strong prognostic marker in endometrial cancer. To further underline the clinical usefulness of this biomarker, we investigated L1CAM as a ... -
Expression of NGAL-specific cells and mRNA levels correlate with inflammation in the salivary gland, and its overexpression in the saliva, of patients with primary Sjögren’s syndrome
(Journal article; Peer reviewed, 2020)Salivary gland involvement is a characteristic feature of primary Sjögren’s syndrome (pSS), where tissue destruction is mediated by infiltrating immune cells, and may be accompanied by the presence of adipose tissue. ... -
Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance
(Peer reviewed; Journal article, 2018-08-23)Memory is indispensable for normal cognitive functioning, and the ability to store and retrieve information is central to mental health and disease. The molecular mechanisms underlying complex memory functions are largely ... -
Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas
(Peer reviewed; Journal article, 2008-02-08)Background It has been suggested that a small population of cells with unique self-renewal properties and malignant potential exists in solid tumors. Such "cancer stem cells" have been isolated by flow cytometry, followed ... -
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
(Peer reviewed; Journal article, 2011-08-24)Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ... -
Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas
(Peer reviewed; Journal article, 2013-05-15)Background: The differential diagnosis between primary and secondary breast cancers might be difficult, especially in poorly differentiated tumors. Thyroid Transcription Factor-1 (TTF-1) has been regarded as a reliable ... -
Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome
(Peer reviewed; Journal article, 2015-03-19)Introduction: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by inflammation of exocrine glands. As autoantibodies are present in a majority of patients, B cells have been suggested to play an ... -
Expression of β-Catenin, E-Cadherin, and α-Smooth Muscle Actin in Basal Cell Carcinoma Before Photodynamic Therapy in Non-recurrent and Recurrent Tumors: Exploring the Ability of Predicting Photodynamic Therapy outcome
(Journal article; Peer reviewed, 2023)Photodynamic therapy (PDT) is an effective and cosmetically beneficial treatment of low-risk basal cell carcinomas (BCCs). To optimize PDT response, it is important to correctly select tumors. We sought to find markers ... -
Expression Profiling of Major Histocompatibility and Natural Killer Complex Genes Reveals Candidates for Controlling Risk of Graft versus Host Disease
(Peer reviewed; Journal article, 2011-01-28)Background: The major histocompatibility complex (MHC) is the most important genomic region that contributes to the risk of graft versus host disease (GVHD) after haematopoietic stem cell transplantation. Matching of MHC ... -
Expression, Purification, and Small Molecule Binding to Cysteine Sulfinic Acid Decarboxylase
(Master thesis, 2023-06-01)Cysteine Sulfinic acid decarboxylase (CSAD) is a PLP-dependent enzyme involved in the biosynthesis of taurine. It converts cysteine sulfinic acid (CSA) into hypotaurine. Hypotaurine is later oxidized into taurine, one of ... -
EXT proteins: Role in heparan sulfate Assembly and in Tumor biology
(Doctoral thesis, 2018-08-24)The exostosin family of proteins is necessary for heparan sulfate biosynthesis. Heparan sulfate polysaccharide biosynthesis is one of several different forms of proteinglycosylation processes that take place in the Golgi ... -
Extended-spectrum β-lactamase producing Klebsiella pneumoniae. A neonatal intensive care unit outbreak, long-term colonization in children and plasmid characteristics
(Doctoral thesis, 2014-12-19)Background: The increasing level of antimicrobial resistance among clinical relevant bacteria, especially the increasing prevalence of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae, is of great concern ... -
Extending contact screening to 50 metre around tuberculosis patients in urban Pakistan : Follow-up of a large Active Case-finding Project
(Doctoral thesis, 2023-03-10)Tuberkulose pasienter som ikke er diagnostisert er et stort helseproblem i samfunnet i Pakistan. I 2020 var det 52% av det antatte totale nye tilfeller som ikke var registrert i det nasjonale TB programmet (NTP) i Pakistan, ... -
Extending contact screening within a 50-m radius of an index tuberculosis patient using Xpert MTB/RIF in urban Pakistan: Did it impact treatment outcomes?
(Journal article; Peer reviewed, 2021)Background Pakistan implemented initiatives to detect tuberculosis (TB) patients through extended contact screening (ECS); it improved case detection but treatment outcomes need assessment. Objectives To compare ... -
Extending protein interaction networks using proteoforms and small molecules
(Journal article; Peer reviewed, 2023)Motivation: Biological network analysis for high-throughput biomedical data interpretation relies heavily on topological characteristics. Networks are commonly composed of nodes representing genes or proteins that are ... -
Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes
(Journal article; Peer reviewed, 2021)Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic ... -
Extensor tendon release in tennis elbow: results and prognostic factors in 80 elbows
(Peer reviewed; Journal article, 2011-03-16)Purpose The objectives of this study were to evaluate the results in the outpatient treatment of recalcitrant lateral epicondylitis with release of the common extensor origin according to Hohmann and to determine any ...