Blar i Faculty of Medicine på tittel
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Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma
(Peer reviewed; Journal article, 2019)Background: Dysregulation of immune checkpoint molecules leads to immune evasion in human tumours but has become a viable target for tumour therapy. Here, we examined expression of Herpes virus entry mediator (HVEM), an ... -
Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis
(Journal article; Peer reviewed, 2022)Several lines of evidence implicate immune abnormalities in the pathophysiology of severe mental disorders (SMD) and comorbid mental disorders. Here, we use the data from genome-wide association studies (GWAS) of autoimmune ... -
Immune regulatory mechanisms in endocrine autoimmune disorders
(Doctoral thesis, 2023-09-15)Ulike mekanismer eksisterer for at immunforsvaret skal lære å skille det som er eget fra det som er fremmed, også kjent som immunologisk toleranse. I noen tilfeller brytes denne toleransen, noe som kan føre til at enkelte ... -
Immune response to influenza after vaccination and infection
(Doctoral thesis, 2016-09-23)Influenza causes great human morbidity and mortality from annual epidemics and pandemics occurring at irregular intervals. The socioeconomic impact of influenza is significant with 5% of adults and 20% of children infected, ... -
Immune Responses in Acute and Convalescent Patients with Mild, Moderate and Severe Disease during the 2009 Influenza Pandemic in Norway
(Peer reviewed; Journal article, 2015-11-25)Increased understanding of immune responses influencing clinical severity during pandemic influenza infection is important for improved treatment and vaccine development. In this study we recruited 46 adult patients during ... -
Immune-instructive copolymer scaffolds using plant-derived nanoparticles to promote bone regeneration
(Journal article; Peer reviewed, 2022)Background Age-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly ... -
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
(Peer reviewed; Journal article, 2018-01-09)Background: Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are ... -
Immunochemistry-Based Diagnosis of Extrapulmonary Tuberculosis: A Strategy for Large-Scale Production of MPT64-Antibodies for Use in the MPT64 Antigen Detection Test
(Journal article; Peer reviewed, 2021)Tuberculosis (TB) is a global health problem. The immunohistochemistry (IHC)-based MPT64 antigen detection test has shown promising results for diagnosing extrapulmonary TB in previous studies. However, the anti-MPT64 ... -
Immunocytochemical detection of Mycobacterium Tuberculosis complex specific antigen, MPT64, improves diagnosis of tuberculous lymphadenitis and tuberculous pleuritis
(Peer reviewed; Journal article, 2014-11-25)Background: A rapid, sensitive and accurate laboratory diagnosis is of prime importance in suspected extrapulmonary tuberculosis (EPTB) cases. However, traditional techniques for the detection of acid-fast bacilli have ... -
The immunogenicity of intranasal adjuvanted pandemic avian influenza vaccine in murine model
(Master thesis, 2009-07-02)Influenza vaccination remains the primary method for the prevention of influenza and the severe complications related to the disease. Development of an intranasal vaccination strategy will not only prevent the disease but ... -
Immunoglobulin-storing histiocytosis: A case based systemic review
(Journal article; Peer reviewed, 2021)Crystal-storing histiocytosis (CSH) is a rare event in disorders associated with monoclonal gammopathy and is mostly associated with the accumulation of immunoglobulins (Igs) in the cytoplasm of histiocytes. In this article, ... -
Immunohaematological reference values in human immunodeficiency virus-negative adolescent and adults in rural northern Tanzania
(Peer reviewed; Journal article, 2009-01-13)Background: The amount of CD4 T cells is used for monitoring HIV progression and improvement, and to make decisions to start antiretroviral therapy and prophylactic drugs for opportunistic infections. The aim of this study ... -
Immunohistochemical biomarkers are prognostic relevant in addition to the ESMO-ESGO-ESTRO risk classification in endometrial cancer
(Journal article; Peer reviewed, 2021)Objective: Pre-operative immunohistochemical (IHC) biomarkers are not incorporated in endometrial cancer (EC) risk classification. We aim to investigate the added prognostic relevance of IHC biomarkers to the ESMO-ESGO-ESTRO ... -
Immunohistochemical detection of p53 in non-malignant and malignant oral lesions associated with snuff dipping in the Sudan and Sweden
(Journal article, 1996)Immunohistochemistry was used to examine the expression of p53 in pre-malignant oral lesions and oral squamous-cell carcinomas (SCCs) from Swedish and Sudanese snuff-dippers, as well as in pre-malignant oral lesions and ... -
Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64
(Peer reviewed; Journal article, 2007-09-25)Background: The aim of this study was to evaluate the diagnostic potential of immunohistochemistry using an antibody to the secreted mycobacterial antigen MPT64, in abdominal and lymph node tuberculosis. Methods: We used ... -
Immunological aspects of acute myelogenous leukemia
(Doctoral thesis, 2007-02-23)Acute myelogenous leukemia (AML) is an aggressive malignancy characterized by accumulation of immature myeloid cells in the bone marrow. The overall disease-free survival is less than 50% even for the younger patients who ... -
The immunological dilemma: Cellular innate and adaptive immune response versus human acute myeloid leukemia
(Peer reviewed; Journal article, 2007)It is generally accepted that acute myelogenous leukemia (AML) patients are immunocompromized. On the other hand, antileukemic immune reactivity is important for the improved survival of AML patients treated with allogeneic ... -
Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses
(Peer reviewed; Journal article, 2018-09-22)Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ... -
Immunological mechanisms of tumour progression. The rationale for natural killer cell based immunotherapy for glioblastoma
(Doctoral thesis, 2013-10-04)Glioblastoma (GBM) is the most frequent and malignant brain tumour, where the patients’ median survival after diagnosis is only 14.6 months. Therefore, concerted research is required to develop novel treatments that will ... -
Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line
(Journal article; Peer reviewed, 2019)Changes in the immune system induced by tyrosine kinase inhibitors (TKI) have been shown to positively correlate with therapy responses in chronic myeloid leukemia (CML). However, only a few longitudinal studies exist and ...