Browsing Faculty of Medicine by Title
Now showing items 4575-4594 of 8826
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Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling
(Peer reviewed; Journal article, 2020)Long non-coding RNAs play critical roles in tumour progression. Through analysis of publicly available genomic datasets, we found that MIR22HG, the host gene of microRNAs miR-22-3p and miR-22-5p, is ranked among the most ... -
Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study
(Peer reviewed; Journal article, 2014-04-24)The risk of osteoporosis increases in inflammatory disorders. In cell-mediated immune activation, interferon (IFN)-γ stimulates macrophage release of neopterin and increases the activity of indoleamine 2,3-dioxygenase ... -
Interferon gamma (IFN-γ)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: The Hordaland Health Study
(Peer reviewed; Journal article, 2014-05-10)Summary The cytokine interferon gamma (IFN-γ) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. High levels of neopterin were associated with increased hip fracture ... -
Interferon-γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study
(Peer reviewed; Journal article, 2014-06-19)Background It has been reported that interferon-γ (IFN-γ)–induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor ... -
Interictal epileptiform discharges vary across age groups
(Journal article; Peer reviewed, 2020-01)Objective: To investigate whether the occurrence and morphology of interictal epileptiform discharges (IEDs) in scalp-EEG change by age. Methods: 10,547 patients who had a standard or sleep deprived EEG recording reported ... -
Interleukin-1 Inhibition and Fatigue in Primary Sjögren's Syndrome – A Double Blind, Randomised Clinical Trial
(Peer reviewed; Journal article, 2012)Objectives Fatigue is a major cause of disability in primary Sjögren's syndrome (pSS). Fatigue has similarities with sickness behaviour in animals; the latter mediated by pro-inflammatory cytokines, in particular interleukin ... -
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome
(Journal article; Peer reviewed, 2019)Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ... -
Interleukin-18 signaling system links to agitation in severe mental disorders
(Journal article; Peer reviewed, 2022)Objective Agitation is a challenging clinical feature in severe mental disorders, but its biological correlates are largely unknown. Inflammasome-related abnormalities have been linked to severe mental disorders and ... -
Interleukin-2 receptor in the pathogenesis of diabetic complications and Sjögren's syndrome
(Doctoral thesis, 2021-12-14)The cytokine interleukin-2 (IL-2) acts as a double-edged sword by promoting both immunity and immune tolerance. Regulatory T cells (Tregs) are responsible for maintaining self-tolerance and constitutively express the high ... -
Interleukin-6 in allogeneic stem cell transplantation: Its possible importance for immunoregulation and as a therapeutic target
(Peer reviewed; Journal article, 2017-06-08)Allogeneic stem cell transplantation is associated with a high risk of treatment-related mortality mainly caused by infections and graft-versus-host disease (GVHD). GVHD is characterized by severe immune dysregulation and ... -
Intermediate care in nursing home after hospital admission: a randomized controlled trial with one year follow-up
(Peer reviewed; Journal article, 2014-12-09)Background: Intermediate care is intended to reduce hospital admissions and facilitate early discharge. In Norway, a model was developed with transfer to intermediate care shortly after hospital admission. Efficacy and ... -
Internal migration and utilization of reproductive and maternity care among women in Pakistan: evidence from a recent National Survey
(Journal article; Peer reviewed, 2023)Background: During the last decades, migratory behavior has had a key role in population growth and redistribution in Pakistan. Migration has far-reaching socioeconomic implications for individuals and society at large ... -
Internalizing Symptom Profiles Among Youth in Foster Care: A Comparison Study
(Journal article; Peer reviewed, 2021)Background: A high prevalence of anxiety and depression is found among youth in foster care. There is limited knowledge on the anxiety and depression symptom profiles of youth in foster care. We examined latent profiles ... -
An international contrast of rates of placental abruption: An age-period-cohort analysis
(Peer reviewed; Journal article, 2015-05-27)Background: Although rare, placental abruption is implicated in disproportionately high rates of perinatal morbidity and mortality. Understanding geographic and temporal variations may provide insights into possible amenable ... -
International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): Rationale for and design of a global registry
(Peer reviewed; Journal article, 2015-03-10)Aims. The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide. ... -
An international road map to improve pain assessment in people with impaired cognition: the development of the Pain Assessment in Impaired Cognition (PAIC) meta-tool
(Peer reviewed; Journal article, 2014-12-10)Background: Pain is common in people with dementia, yet identification is challenging. A number of pain assessment tools exist, utilizing observation of pain-related behaviours, vocalizations and facial expressions. Whilst ... -
International variation in distribution of ASA class in patients undergoing total hip arthroplasty and its influence on mortality: data from an international consortium of arthroplasty registries
(Journal article; Peer reviewed, 2021)Background and purpose — A challenge comparing outcomes from total hip arthroplasty between countries is variation in preoperative characteristics, particularly comorbidity. Therefore, we investigated between-country ... -
International versus national growth charts for identifying small and large-for-gestational age newborns: A population-based study in 15 European countries
(Journal article; Peer reviewed, 2021)Background To inform the on-going debate about the use of universal prescriptive versus national intrauterine growth charts, we compared perinatal mortality for small and large-for-gestational-age (SGA/LGA) infants according ... -
Internet marketing of the herbal product ginger for use against nausea and vomiting
(Master thesis, 2010-05-16)Aim: The purpose of the study was to evaluate Internet marketing of ginger for use against nausea and vomiting during pregnancy (NVP) with particular focus on claims related to safety and efficacy in this indication. Method: ... -
Internettbasert audiologisk rehabilitering av voksne - En litteraturoversikt
(Master thesis, 2022-11-15)