Blar i Faculty of Medicine på tittel
Viser treff 4660-4679 av 8819
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The intronic BRCA1 c.5407-25T>A variant causing partly skipping of exon 23—a likely pathogenic variant with reduced penetrance?
(Peer reviewed; Journal article, 2020-03-20)Rare sequence variants in the non-coding part of the BRCA genes are often reported as variants of uncertain significance (VUS), which leave patients and doctors in a challenging position. The aim of this study was to ... -
The Inverse Association of Body Mass Index with Lung Cancer: Exploring Residual Confounding, Metabolic Aberrations and Within-Person Variability in Smoking
(Journal article; Peer reviewed, 2021)Background: The inverse observational association between body mass index (BMI) and lung cancer risk remains unclear. We assessed whether the association is explained by metabolic aberrations, residual confounding, and ... -
Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinoma
(Peer reviewed; Journal article, 2009-12-08)Background: Members of the PDGF family have been suggested as potential biomarkers for papillary thyroid carcinomas (PTC). However, it is known that both expression and stimulatory effect of PDGF ligands can be affected ... -
Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
(Journal article; Peer reviewed, 2021)Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ... -
Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders Along the Impulsivity-Compulsivity Spectrum
(Journal article; Peer reviewed, 2021)Background Tourette syndrome (TS) is often found comorbid with other neurodevelopmental disorders across the impulsivity-compulsivity spectrum, with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder ... -
Investigating The Healthiness of Online Recipes in Norway Compared to the UK and the US
(Master thesis, 2022-12-15) -
Investigating the human jejunal microbiota
(Journal article; Peer reviewed, 2022)Descriptions of the small intestinal microbiota are deficient and conflicting. We aimed to get a reliable description of the jejunal bacterial microbiota by investigating samples from two separate jejunal segments collected ... -
Investigating the human small intestinal microbiota : Microbiological characterization of jejunal and ileal samples collected during surgery
(Doctoral thesis, 2022-10-25)Kartlegging av tynntarmsmikrobiota hos mennesker : Mikrobiologisk beskrivelse av kirurgiske prøver fra jejunum og ileum Beskrivelser av tynntarmsmikrobiota (tarmflora) i lærebøker og vitenskapelige artikler er lite ... -
Investigating the rationale for COPD maintenance therapy prescription across Europe, findings from a multi-country study
(Journal article; Peer reviewed, 2023)This study aims to understand healthcare professionals’ thoughts and motivations about optimal management and treatment of patients with chronic obstructive pulmonary disease (COPD). We conducted a DELPHI survey through ... -
Investigating the relationship between allocentric spatial working memory and biomarker status in preclinical and prodromal Alzheimer’s disease
(Journal article; Peer reviewed, 2023)The 4 Mountain Test (4MT) is a test of allocentric spatial working memory and has been proposed as an earlier marker of predementia Alzheimer’s disease (AD) than episodic verbal memory. We here compare the 4MT to the CERAD ... -
Investigating the role of vitamin K in Axl-mediated melanoma progression and chemotherapeutic resistance
(Master thesis, 2018-06-29)Metastatic melanoma is a highly aggressive cancer with a very poor prognosis and current therapies remain inadequate. Norway is among the top five countries with the highest incidence of melanoma. Malignant cells carry ... -
Investigating the use of patient involvement and patient experience in quality improvement in Norway: rhetoric or reality?
(Peer reviewed; Journal article, 2013-06-06)Background: Patient involvement in health care decision making is part of a wider trend towards a more bottomup approach to service planning and provision, and patient experience is increasingly conceptualized as a core ... -
Investigating trends in HIV transmission and risk factors in Zambia
(Doctoral thesis, 2008-04-25)The objective of HIV surveillance is to document trends in HIV prevalence and transmission risk in order to make informed policies and to guide prevention and care/treatment programmes. Zambia established a comprehensive ... -
Investigation of complement component C4 copy number variation in human longevity
(Peer reviewed; Journal article, 2014-01-22)Genetic factors have been estimated to account for about 25% of the variation in an adult’s life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences ... -
Investigation of Cross-Reactivity of Anti-Ephrin-B2 Antibody to Other Ephrin-B Members in an Immunohistochemical Study in a Cohort of Oral Squamous Cell Carcinoma
(Journal article, 2022)Ephrin-B1,-B2 and -B3 proteins share a high degree of sequence similarity. Investigation of these proteins as putative prognostic markers in human cancers including oral squamous cell carcinoma (OSCC) has been limited by ... -
Investigation of immune cells in psoriasis patients treated with infliximab
(Master thesis, 2021-05-20)Psoriasis is a chronic inflammatory disease that manifests in the skin affecting both sexes equally and all ages. In Norway, the prevalence reaches 11.43% in adults. Both genetics and environment factors are important in ... -
Investigation of mechanisms leading to early aseptic loosening of hip prostheses. A retrieval study of 27 failed cases of cemented Spectron EF stem in combination with Reflection acetabular cup
(Master thesis, 2016-05-18)Background: More than 1 million people with arthroplasties undergo total hip arthroplasty (THA) surgery every year worldwide. In Norway more than 10 % of the THA cases needed revision operations due to aseptic loosening. ... -
Investigation of perioperative work processes in provision of antibiotic prophylaxis: a prospective descriptive qualitative study across surgical specialties in Norway
(Peer reviewed; Journal article, 2019)Abstract Objective: Surgical site infections are known postoperative complications, yet the most preventable of healthcare-associated infections. Correct provision of surgical antibiotic prophylaxis (SAP) is crucial. Use ... -
Investigation of predictive markers in patients with metastatic melanoma treated with bevacizumab
(Doctoral thesis, 2016-11-22)Background: The incidence of malignant melanoma is still rising among fair- skinned people worldwide, and it is among the three major cancer types in young adults in Norway. Progression free survival and overall survival ... -
Investigation of protein signalling pathways activated by sonoporation in cancer
(Master thesis, 2018-06-29)Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. patients with a metastatic PDAC only survive 3 – 5 months if left untreated and less than 25% of diagnosed patients are eligible for ...